scholarly journals Adding Intra-Articular Growth Hormone to Platelet Rich Plasma under Ultrasound Guidance in Knee Osteoarthritis: A Comparative Double-Blind Clinical Trial

2016 ◽  
Vol 6 (6) ◽  
Author(s):  
Poupak Rahimzadeh ◽  
Farnad Imani ◽  
Seyed-Hamid-Reza Faiz ◽  
Mahmoud-Reza Alebouyeh ◽  
Damoon Azad-Ehyaei ◽  
...  
Keyword(s):  
Clinical Trial ◽  
Growth Hormone ◽  
Knee Osteoarthritis ◽  
Ultrasound Guidance ◽  
Platelet Rich Plasma ◽  
Double Blind ◽  
Double Blind Clinical Trial

scholarly journals SHORT-TERM EFFICACY OF LOW-LEVEL LASER THERAPY IN PATIENTS WITH KNEE OSTEOARTHRITIS: A RANDOMIZED PLACEBO-CONTROLLED, DOUBLE-BLIND CLINICAL TRIAL

2011 ◽  
Vol 46 (5) ◽  
pp. 526-533 ◽  
Author(s):  
Vanessa Ovanessian Fukuda ◽  
Thiago Yukio Fukuda ◽  
Márcio Guimarães ◽  
Silvia Shiwa ◽  
Bianca Del Cor de Lima ◽  
...  
Keyword(s):  
Clinical Trial ◽  
Knee Osteoarthritis ◽  
Laser Therapy ◽  
Low Level Laser Therapy ◽  
Short Term ◽  
Double Blind ◽  
Low Level ◽  
Low Level Laser ◽  
Level Laser ◽  
Double Blind Clinical Trial

scholarly journals A Double-Blind, Active-Controlled Clinical Trial of Sodium Bicarbonate and Calcium Gluconate in the Treatment of Bilateral Osteoarthritis of the Knee

2017 ◽  
Vol 10 ◽  
pp. 117954411668889 ◽  
Author(s):  
María del Carmen Caamaño ◽  
Sandra García-Padilla ◽  
Miguel Ángel Duarte-Vázquez ◽  
Karla Elena González-Romero ◽  
Jorge L Rosado
Keyword(s):  
Clinical Trial ◽  
Sodium Bicarbonate ◽  
Knee Osteoarthritis ◽  
Calcium Gluconate ◽  
Controlled Clinical Trial ◽  
Osteoarthritis Of The Knee ◽  
Short Term ◽  
Double Blind ◽  
Knee Oa ◽  
Double Blind Clinical Trial

Objective: To evaluate the effect of intra-articular injections of sodium bicarbonate with a single (SBCG1) or double dose (SBCG2) of calcium gluconate administered monthly compared with methylprednisolone (MP) for treatment of knee osteoarthritis. Methods: A 3-month, randomized, double-blind clinical trial with patients diagnosed with knee osteoarthritis (OA). The outcome variables were the Western Ontario-McMaster University Osteoarthritis Index (WOMAC) and the Lequesne functional index. Results: After 3 months, all treatments significantly improved in overall WOMAC and Lequesne scores. Mean changes (95% confidence interval) in WOMAC total score and the Lequesne index, respectively, for SBCG1 (−12.5 [−14.3, −10.7]; −9.0 [−11.4, −6.7]) and SBCG2 (−12.3 [−14.3, −10.4]; −8.9 [−10.4, −7.4]) were significantly greater than for MP (−5.0 [−7.2, −2.8]; −3.2 [−4.9, −1.5]) ( P < .001). Conclusions: Intra-articular injections of sodium bicarbonate and calcium gluconate are useful for short-term relief of OA symptoms in patients with bilateral knee osteoarthritis. Both treatments are more effective than MP injections in the reduction of knee OA symptoms. Trial Registration: Clinicaltrials.gov NCT00977444

Use of platelet-rich plasma in periodontal surgery—a prospective randomised double blind clinical trial

2008 ◽  
Vol 13 (2) ◽  
pp. 179-187 ◽  
Author(s):  
L. Harnack ◽  
R. H. Boedeker ◽  
I. Kurtulus ◽  
S. Boehm ◽  
J. Gonzales ◽  
...  
Keyword(s):  
Clinical Trial ◽  
Platelet Rich Plasma ◽  
Periodontal Surgery ◽  
Double Blind ◽  
Double Blind Clinical Trial

Interferential current and photobiomodulation in knee osteoarthritis: A randomized, placebo-controlled, double-blind clinical trial

2021 ◽  
pp. 026921552110120
Author(s):  
Renata Alqualo-Costa ◽  
Érika Patrícia Rampazo ◽  
Gustavo Ribeiro Thome ◽  
Mônica Rodrigues Perracini ◽  
Richard Eloin Liebano
Keyword(s):  
Clinical Trial ◽  
Knee Osteoarthritis ◽  
Pain Intensity ◽  
Rating Scale ◽  
Pain Modulation ◽  
Double Blind ◽  
Time Points ◽  
Double Blind Clinical Trial ◽  
Interferential Current

Objectives: To evaluate the effects of interferential current and photobiomodulation in patients with knee osteoarthritis. Design: A randomized, placebo-controlled, double-blind clinical trial. Setting: Physiotherapy Clinic of City University of São Paulo. Subjects: A total of 184 patients with knee osteoarthritis were recruited and, of these, 168 were included and randomized into four groups with 42 each: interferential current, photobiomodulation, interferential current plus photobiomodulation or placebo groups. One hundred and sixty-four patients completed the study. Intervention: Patients received 12 sessions (three times a week) of treatment: 30 minutes of interferential current (active or placebo) followed by photobiomodulation (active or placebo). Main measures: Primary outcome: pain intensity at rest and during movement (numeric rating scale) after 12 sessions. Secondary outcomes: functional capacity (Timed Up & Go and Sit and Lift tests and Lequesne and WOMAC questionnaires), pressure pain threshold, conditioned pain modulation, and muscle strength production (isokinetic evaluation). Patients were assessed at baseline, after 12 sessions, and three and six months after the end of the treatment. Results: Interferential current plus photobiomodulation reduced pain intensity at rest and during movement compared to placebo and interferential current at all time points ( P < 0.05). Photobiomodulation reduced pain intensity at rest compared to placebo at all time points ( P < 0.05) and compared to interferential current at six months follow-up ( P < 0.05). Photobiomodulation reduced pain intensity during movement compared to placebo at six months follow-up ( P < 0.05). Conclusion: Interferential current plus photobiomodulation or isolated photobiomodulation improve pain intensity in knee osteoarthritis.

A randomized double-blind clinical trial on the treatment of knee osteoarthritis: The efficacy of polynucleotides compared to standard hyaluronian viscosupplementation

The Knee ◽  
2014 ◽  
Vol 21 (3) ◽  
pp. 661-668 ◽  
Author(s):  
Laura S. Giarratana ◽  
Bruno M. Marelli ◽  
Calogero Crapanzano ◽  
Silvia E. De Martinis ◽  
Luca Gala ◽  
...  
Keyword(s):  
Clinical Trial ◽  
Knee Osteoarthritis ◽  
Double Blind ◽  
Double Blind Clinical Trial

scholarly journals Corticosteroids or platelet-rich plasma injections for rotator cuff tendinopathy: a randomized clinical trial study

2021 ◽  
Vol 16 (1) ◽  
Author(s):  
Haleh Dadgostar ◽  
Farinaz Fahimipour ◽  
Alireza Pahlevan Sabagh ◽  
Peyman Arasteh ◽  
Mohammad Razi
Keyword(s):  
Clinical Trial ◽  
Rotator Cuff ◽  
External Rotation ◽  
Platelet Rich Plasma ◽  
Trial Registration ◽  
Clinical Aspects ◽  
Double Blind ◽  
Clinical Trial Registration ◽  
Double Blind Clinical Trial ◽  
Clinical Changes

Abstract Background Studies evaluating the role of both corticosteroids and platelet-rich plasma (PRP) in the treatment of rotator cuff (RC) tendinopathies have been contradicting. We compared structural and clinical changes in RC muscles after corticosteroids and PRP injections. Methods This is a randomized double-blind clinical trial. All individuals with diagnosis of RC tendinitis during 2014–2017 were considered. Individuals were randomly allocated to either receive PRP or corticosteroids. Overall, 3cc of PRP was injected within the subacromial joint and another 3cc was injected at the site of the tendon tear, under the guide of sonography. For the corticosteroid group, 1cc of Depo-medrol 40mg and 1cc of lidocaine (2%) was injected within the subacromial joint. Results Overall, 58 patients entered the study. Comparison of pain, range of motion (ROM), Western Ontario RC (WORC), Disability of Arm-Hand-Shoulder (DASH) scores, and supraspinatus thickness showed significant improvement during follow-ups in both groups (p<0.05). During 3 months of follow-up, pain improvement was significantly better within the PRP group during (from 6.66±2.26 to 3.08±2.14 and 5.53±1.80 to 3.88±1.99, respectively; p=0.023). Regarding ROM, the PRP group had significant improvement in adduction (20.50°±8.23° to 28°±3.61° and 23.21°±7.09° to 28.46°±4.18° for the PRP and corticosteroid groups, respectively; p=0.011) and external rotation (59.66°±23.81° to 76.66°±18.30° and 57.14°±24.69° to 65.57°±26.39°, for the PRP and corticosteroid groups, respectively; p=0.036) compared to the corticosteroid group. Conclusion We found that PRP renders similar results to that of corticosteroids in most clinical aspects among patients with RC tendinopathies; however, pain and ROM may show more significant improvement with the use of PRP. Considering that the use of corticosteroids may be contraindicated in some patients and may be associated with the risk of tendon rupture, we suggest the use of PRP in place of corticosteroid-based injections among patients with RC tendinopathy. Trial registration Clinical trial registration code: IRCT201302174251N9

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