scholarly journals New Screening Method For Cervical Cancer- Polar Probe

2020 ◽  
pp. 587-595
Author(s):  
Halis ÖZDEMİR ◽  
Gonca ÇOBAN ŞERBETÇİOĞLU ◽  
Ali AYHAN
Keyword(s):  
Cervical Cancer ◽  
Screening Method ◽  
Polar Probe

scholarly journals Analysis of Compound Stained Cervical Cell Images Using Multi-Spectral Imaging

2021 ◽  
Vol 11 (12) ◽  
pp. 5628
Author(s):  
Run Fang ◽  
Libo Zeng ◽  
Fan Yi
Keyword(s):  
Cervical Cancer ◽  
Mouse Liver ◽  
Imaging System ◽  
Color Image ◽  
Imaging Technique ◽  
Screening Method ◽  
Spectral Imaging ◽  
High Accuracy ◽  
Cervical Cell ◽  
Real World Applications

Multi-spectral imaging technique plays an important role in real-world applications such as medicine and medical detections. This paper proposes a cervical cancer cell screening method to simultaneously adopt TBS classification and DNA quantitative analysis for a single cell smear. Through using compound staining on a smear, the cytoplasm is stained by Papanicolauo and the nucleus is stained by Feulgen. The main evaluation parameter is the DNA content of the nucleus, not the subjective description of cell morphology, which is more objective than the TBS classification method and reduces the chances of missing a diagnosis due to subjective factors. Each nucleus has its own DI value and color image of the whole cell, which is convenient for doctors as it allows them to review and confirm the morphology of cells with a nucleus DI of over 2.5. Mouse liver smears and cervical cases are utilized as the measuring specimens to evaluate the performance of the microscope multi-spectral imaging system; illustrative results demonstrate that the proposed system qualifies, with high accuracy and reliability, and further presents wide application prospects in the early diagnosis of cervical cancer.

scholarly journals Cervical Cancer Screening Programs in Europe: The Transition Towards HPV Vaccination and Population-Based HPV Testing

Viruses ◽  
2018 ◽  
Vol 10 (12) ◽  
pp. 729 ◽  
Author(s):  
Andreas Chrysostomou ◽  
Dora Stylianou ◽  
Anastasia Constantinidou ◽  
Leondios Kostrikis
Keyword(s):  
Cervical Cancer ◽  
Cancer Screening ◽  
Cervical Cancer Screening ◽  
Hpv Vaccination ◽  
Screening Method ◽  
Population Based ◽  
Screening Tests ◽  
Screening Methods ◽  
Hpv Testing ◽  
Screening Programs

Cervical cancer is the fourth most frequently occurring cancer in women around the world and can affect them during their reproductive years. Since the development of the Papanicolaou (Pap) test, screening has been essential in identifying cervical cancer at a treatable stage. With the identification of the human papillomavirus (HPV) as the causative agent of essentially all cervical cancer cases, HPV molecular screening tests and HPV vaccines for primary prevention against the virus have been developed. Accordingly, comparative studies were designed to assess the performance of cervical cancer screening methods in order to devise the best screening strategy possible. This review critically assesses the current cervical cancer screening methods as well as the implementation of HPV vaccination in Europe. The most recent European Guidelines and recommendations for organized population-based programs with HPV testing as the primary screening method are also presented. Lastly, the current landscape of cervical cancer screening programs is assessed for both European Union member states and some associated countries, in regard to the transition towards population-based screening programs with primary HPV testing.

Identification of ideal strategy of cervical cancer screening in Japan based on Fukui cervical cancer screening study.

2017 ◽  
Vol 35 (15_suppl) ◽  
pp. e17025-e17025
Author(s):  
Tetsuji Kurokawa ◽  
Akiko Shinagawa ◽  
Yoko Chino ◽  
Motohiro Kobayashi ◽  
Yoshio Yoshida
Keyword(s):  
Cervical Cancer ◽  
Cancer Screening ◽  
Positive Predictive Value ◽  
Cervical Cancer Screening ◽  
Predictive Value ◽  
Screening Method ◽  
Hpv Testing ◽  
Abnormal Cytology ◽  
Predictive Values ◽  
Hpv Status

e17025 Background:The estimated age-standardized incidence rate for cervical cancer is higher in Japan than in North America and the UK. It is important to improve cancer screening. The introduction of HPV testing with cytology for triage of those that test positive for cervical cancer screening has been challenging. The Fukui Cervical Cancer Screening (FCCS) study was designed to determine the best cervical cancer screening method in the Japanese population. We performed a subanalysis using baseline data of FCCS study to determine the performance of cytology, the human papillomavirus (HPV) testing and cotesting with cytology and HPV testing, and to evaluate whether the stratification of HPV16, HPV18, and 12 other hrHPV types appropriately balances risks and harms in the Japanese cancer screening population. Methods:The study enrolled 7,584 women aged 25 years or older undergoing routine screening. All women underwent liquid-based cytology (LBC) and cobas HPV testing. Women with abnormal cytology regardless of the HPV status, women with positive hrHPV results regardless of cytology results, and women randomly selected from among those with normal cytology and negative hrHPV results were referred for colposcopy. Results:The prevalence of hrHPV, HPV16, and HPV18 was 6.8%, 1.2%, and 0.5%, respectively. The estimated sensitivities for cervical intraepithelial neoplasia (CIN) 2 or worse for cytology, HPV testing, and cotesting with cytology and HPV testing were 71%, 92%, and 100%, respectively. The estimated positive predictive values for cytology, HPV testing, and cotesting with cytology and HPV testing were 33%, 21% and 21%, respectively. Using a strategy whereby those with abnormal cytology or positive HPV16 genotype undergo colposcopy and biopsy results in a sensitivity of 85% and a positive predictive value of 33%. This strategy results in improved sensitivity while at the same time maintains the positive predictive value compared to screening with cytology alone. Conclusions:Baseline data from the FCCS study suggests that strategy of using colposcopy for women with abnormal cytology and/or HPV16 positivity appropriately balances risks and harms for Japanese women. Clinical trial information: UMIN000025977.

scholarly journals Concordance in HPV Detection Between Self-Collected and Health Provider–Collected Cervicovaginal Samples Using careHPV in Tanzanian Women

2021 ◽  
pp. 985-991
Author(s):  
Johnson J. Katanga ◽  
Vibeke Rasch ◽  
Rachel Manongi ◽  
Andrea B. Pembe ◽  
Julius D. Mwaiselage ◽  
...  
Keyword(s):  
Cervical Cancer ◽  
Cancer Screening ◽  
High Risk ◽  
Cervical Cancer Screening ◽  
Screening Method ◽  
Health Provider ◽  
Limited Information ◽  
Sample Collection ◽  
Hpv Dna ◽  
High Risk Hpv

PURPOSE Cervical cancer screening is one of the strategies to prevent the disease among women at risk. Human papillomavirus (HPV) DNA testing is increasingly used as the cervical cancer screening method because of its high sensitivity. Self-collection of cervical specimens has the potential to improve participation. However, there is only limited information on comparison between self-collected and provider-collected samples with regard to detection of high-risk HPV using the careHPV method. The study aimed to compare HPV detection by careHPV in self-collected and provider-collected cervical samples and to assess the acceptability of self-collection techniques. MATERIAL AND METHODS Women attending cervical cancer screening clinics at Ocean Road Cancer Institute, Kilimanjaro Christian Medical Centre or Mawenzi Hospital in Tanzania were included in the study. They underwent a face-to-face interview, HIV testing, and collected a self-sample using Evalyn Brush. Subsequently, they had a cervical sample taken by a health provider. Both samples were tested for high-risk HPV DNA using careHPV. RESULTS Overall, 464 women participated in the study. The high-risk HPV prevalence was 19.0% (95% CI, 15.6 to 22.9) in the health provider samples, but lower (13.8%; 95% CI, 10.9 to 17.3) in the self-collected samples. There was a good overall agreement 90.5% (95% CI, 87.5 to 93.0) and concordance (κ = 0.66; 95% CI, 0.56 to 0.75) between the two sets of samples. Sensitivity and specificity were 61.4% (95% CI, 50.4 to 71.6) and 97.3% (95% CI, 95.2 to 98.7), respectively, varying with age. Most women preferred self-collection (79.8%). CONCLUSION Overall, self-sampling seems to be a reliable alternative to health-provider collection and is acceptable to the majority of women. However, instructions on proper procedures for sample collection to the women are important.

scholarly journals Cervical Cancer Knowledge and Prevention Practices among Female Civil Servants in Awka South Local Government Area, Anambra State

2021 ◽  
pp. 36-43
Author(s):  
Georgy O. Obiechina ◽  
Muo Chiamaka Euphemia
Keyword(s):  
Cervical Cancer ◽  
Local Government ◽  
Pap Smear ◽  
Scale Up ◽  
Screening Method ◽  
Local Government Area ◽  
Civil Servants ◽  
Cancer Knowledge ◽  
Chi Square ◽  
Validated Questionnaire

Background: Cervical cancer is a potentially preventable disease if appropriate screening and prophylactic strategies are employed. However, the lack of knowledge and prevention practices can result in the underutilization of preventive strategies. Objective: The objectives of this study were to determine the cervical cancer knowledge and prevention practices among female civil servants in Awka South Local Government Area. Materials and Methods: A cross-sectional research survey design was used to accomplish the purpose of the study. A self-structured and validated questionnaire was used to collect data from the sample of 335 female civil servants, while313 returned rate of female civil servants was used to analyze the data. Percentage, mean and standard deviation were used to analyze the research questions, while Chi-Square and ANOVA were used to test the hypotheses at 0.05 alpha level. Results:  Findings revealed that 194 (61.98%)  of the respondents had no knowledge of cervical cancer while 119 (38.02%)  had knowledge of cervical cancer, however, an average  weighted mean score of  x 2.63 and ± 0.95  had a positive response that using pap smear as a procedure to test for cervical cancer is the best screening method while most of the respondents revealed that it is advisable  to go for treatment once there is a sign of STDs. Chi-Square value of difference in mean knowledge of cervical cancer among female civil servants in Awka South Local Government Area revealed that the calculated X2-value yielded 257, with significant value of 0.000 is less than P-value (P<0.05). Conclusion: It was concluded that when knowledge about cervical cancer and its prevention is consistently communicated through difference media, relatively high number of females may be aware. Based on the conclusion, it was recommended, among others, the need for more sensitization campaigns to bridge the identified knowledge gaps and scale up cervical cancer screening services to all women to increase service uptake.

scholarly journals ThinPrep cytology combined with HPV detection in the diagnosis of cervical lesions in 1622 patients

PLoS ONE ◽  
2021 ◽  
Vol 16 (12) ◽  
pp. e0260915
Author(s):  
Sulaiya Husaiyin ◽  
Zhen Jiao ◽  
Kailibinuer Yimamu ◽  
Reyilanmu Maisaidi ◽  
Lili Han ◽  
...  
Keyword(s):  
Cervical Cancer ◽  
Precancerous Lesions ◽  
Screening Method ◽  
Diagnostic Value ◽  
Youden Index ◽  
Hpv Testing ◽  
Combined Method ◽  
Cervical Lesions ◽  
Hpv Dna ◽  
Diagnostic Values

The timely detection of precancerous lesions and early intervention can greatly reduce cervical cancer occurrence. The current study aimed to assess the diagnostic value and accuracy of different methods of cervical lesion screening. A total of 1622 females who visited the Outpatient Department of Xinjiang Uyghur Autonomous Region People’s Hospital between January and December 2018 were consecutively enrolled. All participants underwent separate high-risk human papilloma virus (HR-HPV) DNA detection, ThinPrep cytology testing (TCT) and colposcopic biopsy. Their medical records were retrospectively analyzed. While considering biopsy outcomes as the gold standard, the diagnostic values of TCT, HR-HPV testing, and TCT+HR-HPV testing for cervical cancer screening were compared. The sensitivity, specificity and Youden index of each method were calculated. Among the different methods, TCT+HR-HPV testing had the highest sensitivity (89.8%), followed by TCT (79.9%) and HR-HPV testing (49.2%). The combined method also had the highest Youden value, and its screening outcomes exhibited the highest consistency with those of biopsy. In addition, the combined method had the largest area under the receiver operating characteristic (ROC) curve, which was 0.673 (0.647, 0.699), compared with any other screening method. Compared with TCT or HR-HPV testing alone, TCT+HR-HPV testing serves as a better screening method for cervical cancer and precancerous lesions.

scholarly journals Squamous lesions with glandular involvement: conventional cytology versus liquid-based cytology

2017 ◽  
Author(s):  
Telma Oliveira ◽  
Vera Azevedo ◽  
Rute Dominguez
Keyword(s):  
Cervical Cancer ◽  
Human Papillomavirus ◽  
European Country ◽  
Incidence Rate ◽  
Screening Method ◽  
Hpv Infection ◽  
Cervical Cytology ◽  
Western European Country ◽  
Conventional Cytology ◽  
Liquid Based Cytology

Portugal is the Western European country with the highest incidence rate of cervical cancer, being the Human Papillomavirus (HPV) infection its main cause. Cervical cytology is the most widely used screening method for the prevention and detection of cervical cancer, either by conventional means or by liquid basis. Conventional cytological preparations have more limitations than liquid-based preparations, however, when dealing with glandular lesions, both conventional and liquid-based cytology have some drawbacks. We report the case of a 31-year-old woman whose results from the screening cytology tests diverge from histological diagnosis. With this study we intend to highlight the limitations of conventional cytology in relation to the liquid-based cytology in the diagnostic of glandular lesions.

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