scholarly journals Probable Interaction of MMP-2 and VEGF in Testicular Deteriorations Related to Aging

2019 ◽  
pp. 735-741
Author(s):  
Servet Kizildag ◽  
Ferda Hosgorler ◽  
Basar Koc ◽  
Ozgur Golgelioglu ◽  
Guven Guvendi ◽  
...  
Keyword(s):  
Probable Interaction

The existence during gestation of an immunological buffer zone at the interface between maternal and foetal tissues

1975 ◽  
Vol 271 (912) ◽  
pp. 343-361 ◽  
Keyword(s):  
Buffer Zone ◽  
Placental Lactogen ◽  
Apical Plasma Membrane ◽  
Hormonal Changes ◽  
Endocrine Activity ◽  
Maternal Tissue ◽  
Local Survival ◽  
Receptor Sites ◽  
Probable Interaction ◽  
Immunological Attack

In mammalian pregnancy the trophoblast normally constitutes an uninterrupted boundary of foetal tissue in immediate contact with maternal tissue, including blood in some species, and is the decisive immunological barrier to rejection of the foetus as an allograft. The ability of the trophoblast to function as a barrier evidently results from its capacity to resist immunological attack by either alloantibody or alloimmune cells and to prevent immunocompetent cells from reaching and damaging the foetus but, as yet, there is no general agreement regarding the means by which it exercises these functions. In view of the dramatic hormonal changes that occur during pregnancy and the undisputed involvement of trophoblast in these endocrine events, the possibility exists of an interaction between the hormones of pregnancy and the immunological phenomena. The present account furnishes evidence that endocrine activity at the maternal surface of the trophoblast, the presumptive site of the immunological frontier between foetus and mother, may be a factor in its local survival at implantation. The placental hormones so far known that are capable of blocking the antigen receptor sites of the mother’s lymphocytes and thus preventing the latter from reacting with the foetal antigens are the glycoprotein, human chorionic gonadotrophin (HCG) and the polypeptide hormone, human chorionic somatomammotrophin (HCS) or human placental lactogen (HPL), both of which are specific to the human placenta. The origin of these hormones, their spatial distribution and their probable interaction with placental steroid hormones are discussed. It is argued that the place of highest concentration of these hormones is on the surface of the syncytial microvilli and the adjacent caviolae of the apical plasma membrane, as well as on the surfaces of the persisting cytotrophoblastic cells of the basal plate (cytotrophoblastic shell), the cell islands and the septa - precisely where the immunological challenge of the foetal allograft to the maternal host occurs. An explanation is offered for the continuing production of the voluminous quantities of these hormones during human pregnancy.

scholarly journals Possible genetically determined mechanisms of arterial hypertension in tobacco smoking

Kardiologiia ◽  
2019 ◽  
Vol 59 (1S) ◽  
pp. 4-10
Author(s):  
N. V. Maltseva ◽  
A. Sh. Smirnova ◽  
A. C. Rublevskaya ◽  
N. A. Bichan
Keyword(s):  
Nitric Oxide ◽  
Arterial Hypertension ◽  
Tobacco Smoking ◽  
Endothelial Nitric Oxide Synthase ◽  
Gestational Period ◽  
Genomic Studies ◽  
Genetically Determined ◽  
Oxide Synthase ◽  
Endothelial Nitric Oxide ◽  
Probable Interaction

Te increase in the prevalence of arterial hypertension (AH) in populations, ineffective treatment, the need for risk stratifcation, prevention, early diagnosis and successful treatment, actualize genomic studies to develop a personalized therapeutic approach to AH. Te review investigates the possible genetically determined mechanisms of the development of hypertension and endothelial dysfunction caused by polymorphism of the genes of endothelial nitric oxide synthase (eNOS) and enzymes of phases I and II of the xenobiotics detoxifcation system. Te probable interaction of both systems under the influence of harmful environmental factors, including tobacco smoking, and in the gestational period is discussed. It is proposed to study AH candidate genes in the xenobiotics detoxifcation system, the carriage of different variants of which can determine the sensitivity or resistance to antihypertensive pharmacotherapy, which can be useful for developing of the personalized tactics of managing patients with AH.

Probable Interaction between Trazodone and Carbamazepine

2011 ◽  
Vol 44 (04) ◽  
pp. 158-159 ◽  
Author(s):  
A. Sánchez-Romero ◽  
A. Mayordomo-Aranda ◽  
R. García-Delgado ◽  
J. A. Durán-Quintana
Keyword(s):  
Probable Interaction

Probable Interaction Between Warfarin and Torsemide

2008 ◽  
Vol 42 (12) ◽  
pp. 1893-1898 ◽  
Author(s):  
Jennifer Bird ◽  
Carlos Carmona
Keyword(s):  
Probable Interaction

Probable Interaction Between Lycium barbarum (Goji) and Warfarin

2012 ◽  
Vol 32 (3) ◽  
pp. e50-e53 ◽  
Author(s):  
Claudio A. Rivera ◽  
Carol L. Ferro ◽  
Adam J. Bursua ◽  
Ben S. Gerber
Keyword(s):  
Lycium Barbarum ◽  
Probable Interaction

Probable interaction between efavirenz and cyclosporine

AIDS ◽  
2002 ◽  
Vol 16 (3) ◽  
pp. 505-506 ◽  
Author(s):  
Alice Tseng ◽  
Mary E. Nguyen ◽  
Carl Cardella ◽  
Atul Humar ◽  
John Conly
Keyword(s):  
Probable Interaction

Transient Elevation of International Normalized Ratio During Cisplatin-Based Chemotherapy in Patients Who are Taking Warfarin

2011 ◽  
Vol 45 (10) ◽  
pp. 1308-1308 ◽  
Author(s):  
Ryoichi Yano ◽  
Tetsuji Kurokawa ◽  
Hideaki Tsuyoshi ◽  
Akiko Shinagawa ◽  
Yoko Sawamura ◽  
...  
Keyword(s):  
International Normalized Ratio ◽  
Target Range ◽  
Probability Scale ◽  
Common Drug ◽  
Case Summary ◽  
The Common ◽  
Transient Elevation ◽  
Interaction Probability ◽  
Antineoplastic Chemotherapy ◽  
Probable Interaction

Objective: To report 2 cases of a probable interaction between cisplatin and warfarin. Case Summary: Two cases of transient elevation of international normalized ratio (INR) during Irinotecan (60 mg/m2 on days 1, 8, and 15) plus cisplatin (60 mg/m2 on day 1) chemotherapy with concomitant warfarin are presented. In both cases, warfarin dosages were stable at the therapeutic target range prior to initiation of chemotherapy. Granisetron hydrochloride (3 mg on days 1, 6, and 15) and dexamethasone (13.2 mg on day 1 and 6.6 mg on days 2, 3, 8, and 15) were used prior to irinotecan administration in both patients. In addition, aprepitant was administered to both patients for 3–5 days with cisplatin. One of these patients also received aprepitant with irinotecan on days 8 and 15. During chemotherapy, INR was transiently elevated almost 1.5-fold over baseline level on day 3. This variation did not occur in subsequent irinotecan cycles on days 8 and 15. The timing of these increases was similar in each of the cycles. Discussion: Cisplatin was the common drug in the cases presented and therefore could be related to the INR elevations. To our knowledge, these are the first reports of an Interaction between warfarin and irinotecan-cisplatin chemotherapy, but reports of a similar interaction with chemotherapy including platinum derivatives exist. Use of the Horn Drug Interaction Probability Scale indicated a probable interaction between warfarin and cisplatin. Conclusions: Cisplatin might affect the anticoagulation function of warfarin. Careful INR monitoring is necessary during antineoplastic chemotherapy with cisplatin in patients taking warfarin.

scholarly journals Effect of adjuvant drugs on the analgesic activity of opioid morphine analgesics and compound RU-1205

2021 ◽  
Vol 7 (3) ◽  
pp. 41-47
Author(s):  
Alexander A. Spasov ◽  
Olesya Iu. Grechko ◽  
Natalya V. Eliseeva ◽  
Yuliya V. Lifanova ◽  
Angelina N. Aleksandrenkova
Keyword(s):  
Analgesic Activity ◽  
Analgesic Effect ◽  
Opioid Analgesics ◽  
Benzodiazepine Receptor ◽  
Tail Flick ◽  
Opioid Agonist ◽  
Tail Flick Test ◽  
Kappa Agonist ◽  
Kappa Opioid Agonist ◽  
Probable Interaction

Introduction: Adjuvant medications can be used to increase the analgesic effect of opioid analgesics, reduce the manifestation of side effects, and also for premedication. This paper provides information on the effect of clonidine, haloperidol, metocloparmide, diazepam, midazolam on opioid analgesics: - morphine and the selective kappa-opioid agonist compound RU-1205. Materials and methods: A probable interaction between RU-1205, morphine and adjuvant drugs in pain behaviors was carried out on the model of somatogenic pain. 95 male mice received either RU-1205 (5 mg/kg, i.p.) and morphine (1 mg/kg, i.p.) separately or in combination with haloperidol (0.45 mg/kg, i.p.); midazolam (0.3 mg/kg, i.p.); diazepam (1 mg/kg, i.p.); metoclopramide (5 mg/kg, i.p.), and clonidine (1 mg/kg, i.p.). The analgesic effect was assessed by tail flick test. Registration of the latent period of the reaction was carried out 30, 60 and 90 minutes after the adjuvant drug administration. Results: When studying the interaction with morphine, it was found that clonidine, haloperidol and metoclopramide enhanced the effects; diazepam offset them, and midazolam had no affect on the analgesic properties. In the course of the studies, RU-1205 showed an increase in analgesic activity when combined with clonidine, a slight increase with midazolam, and a decrease when co-administered with diazepam. Haloperidol had no influence on the effect of RU-1205, while metoclopramide both potentiated and reduced the analgesic effect. Discussion: Pharmacodynamic and pharmacokinetic interactions of RU-1205 with an α2AR agonist, benzodiazepine receptor agonists, D2P antagonist, and σ-receptor blocker were established. Conclusion: The presented data make it possible to more accurately formulate ideas about the localization and action mechanism of the kappa-agonist of opioid receptors, the compound RU-1205.

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