scholarly journals Endovascular coil embolization of unruptured intracranial aneurysm in a patient with von Willebrand's disease: case report

2009 ◽  
Vol 3 (3) ◽  
pp. 181-186 ◽  
Author(s):  
Noriaki MATSUBARA ◽  
Shigeru MIYACHI ◽  
Takashi IZUMI ◽  
Takehiro NAITO ◽  
Kenichi HARAGUCHI ◽  
...  
Keyword(s):  
Case Report ◽  
Intracranial Aneurysm ◽  
Coil Embolization ◽  
Unruptured Intracranial Aneurysm ◽  
Von Willebrand's Disease ◽  
Von Willebrand’S Disease ◽  
Disease Case ◽  
Endovascular Coil Embolization

scholarly journals Cortical Blindness During Coil Embolization of an Unruptured Intracranial Aneurysm-Case Report-

2004 ◽  
Vol 44 (8) ◽  
pp. 416-419 ◽  
Author(s):  
Jun SHINODA ◽  
Yasuhiko AJIMI ◽  
Motoyuki YAMADA ◽  
Satoshi ONOZUKA
Keyword(s):  
Case Report ◽  
Intracranial Aneurysm ◽  
Coil Embolization ◽  
Cortical Blindness ◽  
Unruptured Intracranial Aneurysm

scholarly journals Von Willebrand's disease: case report and review of literature

2017 ◽  
Vol 27 ◽  
Author(s):  
Hanae Echahdi ◽  
Brahim El Hasbaoui ◽  
Mohamed El Khorassani ◽  
Aoma Agadr ◽  
Mohamed Khattab
Keyword(s):  
Case Report ◽  
Review Of Literature ◽  
Von Willebrand's Disease ◽  
Von Willebrand’S Disease ◽  
Disease Case

Abstract WMP28: Association Between Diffusion Positive Lesion and Antiplatelet Drug Resistance After Coiling for Unruptured Intracranial Aneurysm

Stroke ◽  
2016 ◽  
Vol 47 (suppl_1) ◽  
Author(s):  
Kyung Il Jo ◽  
Je Young Yeon ◽  
Jong Soo Kim ◽  
Jong Soo Kim ◽  
Seung Chyul Hong
Keyword(s):  
Drug Resistance ◽  
Intracranial Aneurysm ◽  
Coil Embolization ◽  
Antiplatelet Drug ◽  
Unruptured Intracranial Aneurysm ◽  
Cutoff Values ◽  
Unruptured Intracranial Aneurysms ◽  
Endovascular Coil Embolization ◽  
Antiplatelet Drug Resistance ◽  
Aneurysm Coiling

Background: The purpose of this study was to verify the association between immediate post-procedural thromboembolic infarction and antiplatelet drug resistance after endovascular coil embolization for unruptured intracranial aneurysm. Method: This study included 338 aneurysm cases between October 2012 and March 2015. All patients received post-procedural MRI within 48 hours after endovascular coil embolization. Antiplatelet drug resistance was checked a day before the procedure using the VerifyNow system. Abnormal antiplatelet response was defined as more than 550 aspirin response units (ARU) and more than 240 P2Y12 receptor reaction units (PRU). Also, we explored the optimal cutoff values of ARU and PRU. The primary outcome was radiologic infarction based on post-procedural MRI. Results: Among 338 unruptured intracranial aneurysms, 32 (9.5%) and 105 (31.1%) had abnormal ARU and PRU values, respectively. Radiologic infarction was associated with old age (≥65, adjusted odds ratio (OR)1.777, 95% confidence interval (CI) 1.080-2.925) only with defined abnormal antiplatelet response (ARU≥550, PRU≥240). PRU values in the top 10 th percentile (>294) were associated with radiologic infarction ( p =0.003, OR 4.8, 95% CI 1.708-13.492). Using this cutoff value, age (OR 2.287, 95% CI 1.282-4.079), PRU (>294, OR 3.431 95% CI 1.528-7.706), and hyperlipidemia (OR 2.046 95% CI 1.041-4.020) were associated with radiologic infarction in multivariate analysis. Conclusions: Radiologic infarction after coiling for unruptured aneurysm was closely associated with age. Only very high PRU values (>294) predicted post-procedural infarction. Further controlled studies are needed to determine precise cutoff values which could provide information regarding the optimal antiplatelet regimen for aneurysm coiling.

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