scholarly journals The Role of Pentose Phosphate Pathway in the Destruction of Aged Erythrocytes

1968 ◽  
Vol 7 (1) ◽  
pp. 70-77
Author(s):  
Kiyoyasu Nagai ◽  
Mikio Shimotani ◽  
Hiroshi Abe
Keyword(s):  
Pentose Phosphate Pathway ◽  
Pentose Phosphate

A model for the role of the proline-linked pentose phosphate pathway in polymeric dye tolerance in oregano

2001 ◽  
Vol 36 (10) ◽  
pp. 941-946 ◽  
Author(s):  
Zuoxing Zheng ◽  
Urja Sheth ◽  
Mohan Nadiga ◽  
Jennifer L. Pinkham ◽  
Kalidas Shetty
Keyword(s):  
Pentose Phosphate Pathway ◽  
Pentose Phosphate ◽  
Polymeric Dye

Significance of the Non-Oxidative Pentose Phosphate Pathway in Aspergillus oryzae Grown on Different Carbon Sources

1991 ◽  
Vol 46 (3-4) ◽  
pp. 223-227 ◽  
Author(s):  
Maria Luisa Peleato ◽  
Teresa Muiño-Blanco ◽  
José Alvaro Cebrian Pérez ◽  
Manuel José López-Pérez
Keyword(s):  
Aspergillus Oryzae ◽  
Pentose Phosphate Pathway ◽  
Enzyme Activities ◽  
Developmental Stages ◽  
Carbon Sources ◽  
Pentose Phosphate ◽  
Oxidative Pentose Phosphate Pathway ◽  
Pentose Pathway ◽  
Hexose Phosphates

Specific enzyme activities of the non-oxidative pentose phosphate pathway in Aspergillus oryzae mycelia grown on different carbon sources were determined. Mycelia grown on glucose, mannitol and ribose show the highest specific activities, ribose 5-phosphate isomerase being specially very enhanced. Moreover, transketolase, transaldolase, ribose 5-phosphate isomerase and ribulose 5-phosphate 3-epimerase were determined in different developmental stages of mycelia grown on glucose, mannitol and ribose. The non-oxidative pentose phosphate pathway is more active during conidiogenesis, except for ribulose 5-phosphate 3-epimerase, suggesting a fundamental role of this pathway during that stage to supply pentoses for nucleic acids biosynthesis. A general decrease of the enzyme activities was found in sporulated mycelia. Arabinose 5-phosphate was tested as metabolite of the pentose pathway. This pentose phosphate was not converted into hexose phosphates or triose phosphates and inhibits significantly the ribose 5-phosphate utilization, being therefore unappropriate to support the Aspergillus oryzae growth.

scholarly journals Wnt5a Increases the Glycolytic Rate and the Activity of the Pentose Phosphate Pathway in Cortical Neurons

2016 ◽  
Vol 2016 ◽  
pp. 1-13 ◽  
Author(s):  
Pedro Cisternas ◽  
Paulina Salazar ◽  
Carmen Silva-Álvarez ◽  
L. Felipe Barros ◽  
Nibaldo C. Inestrosa
Keyword(s):  
Glucose Metabolism ◽  
Wnt Signaling ◽  
Pentose Phosphate Pathway ◽  
Neurodegenerative Disorders ◽  
Metabolic Flux ◽  
High Energy ◽  
Pentose Phosphate ◽  
The Brain ◽  
Glycolytic Rate

In the last few years, several reports have proposed that Wnt signaling is a general metabolic regulator, suggesting a role for this pathway in the control of metabolic flux. Wnt signaling is critical for several neuronal functions, but little is known about the correlation between this pathway and energy metabolism. The brain has a high demand for glucose, which is mainly used for energy production. Neurons use energy for highly specific processes that require a high energy level, such as maintaining the electrical potential and synthesizing neurotransmitters. Moreover, an important metabolic impairment has been described in all neurodegenerative disorders. Despite the key role of glucose metabolism in the brain, little is known about the cellular pathways involved in regulating this process. We report here that Wnt5a induces an increase in glucose uptake and glycolytic rate and an increase in the activity of the pentose phosphate pathway; the effects of Wnt5a require the intracellular generation of nitric oxide. Our data suggest that Wnt signaling stimulates neuronal glucose metabolism, an effect that could be important for the reported neuroprotective role of Wnt signaling in neurodegenerative disorders.

The role of maslinic acid in the pentose phosphate pathway during growth of gilthead sea bream(Sparus Aurata)

2013 ◽  
Vol 19 (5) ◽  
pp. 709-720 ◽  
Author(s):  
Eva E. Rufino-Palomares ◽  
Fernando J. Reyes-Zurita ◽  
Leticia García-Salguero ◽  
Juan Peragón ◽  
Manuel de la Higuera ◽  
...  
Keyword(s):  
Pentose Phosphate Pathway ◽  
Sparus Aurata ◽  
Pentose Phosphate ◽  
Gilthead Sea Bream ◽  
Sea Bream ◽  
Maslinic Acid

scholarly journals The pentose phosphate pathway constitutes a major metabolic hub in pathogenic Francisella

2021 ◽  
Vol 17 (8) ◽  
pp. e1009326
Author(s):  
Héloise Rytter ◽  
Anne Jamet ◽  
Jason Ziveri ◽  
Elodie Ramond ◽  
Mathieu Coureuil ◽  
...  
Keyword(s):  
Pentose Phosphate Pathway ◽  
Metabolic Pathways ◽  
Pathogenic Bacteria ◽  
Metabolic Networks ◽  
Tricarboxylic Acid Cycle ◽  
Sulfur Metabolism ◽  
Time Lapse ◽  
Pentose Phosphate ◽  
Francisella Novicida

Metabolic pathways are now considered as intrinsic virulence attributes of pathogenic bacteria and thus represent potential targets for antibacterial strategies. Here we focused on the role of the pentose phosphate pathway (PPP) and its connections with other metabolic pathways in the pathophysiology of Francisella novicida. The involvement of the PPP in the intracellular life cycle of Francisella was first demonstrated by studying PPP inactivating mutants. Indeed, we observed that inactivation of the tktA, rpiA or rpe genes severely impaired intramacrophage multiplication during the first 24 hours. However, time-lapse video microscopy demonstrated that rpiA and rpe mutants were able to resume late intracellular multiplication. To better understand the links between PPP and other metabolic networks in the bacterium, we also performed an extensive proteo-metabolomic analysis of these mutants. We show that the PPP constitutes a major bacterial metabolic hub with multiple connections to glycolysis, the tricarboxylic acid cycle and other pathways, such as fatty acid degradation and sulfur metabolism. Altogether our study highlights how PPP plays a key role in the pathogenesis and growth of Francisella in its intracellular niche.

Sign in / Sign up

Export Citation Format

Share Document