Cytological differentiation of pancreatic intraepithelial neoplasia by cytologic diagnosis of pancreatic juice obtained by endoscopic nasopancreatic drainage

2017 ◽  
Vol 56 (1) ◽  
pp. 1-8 ◽  
Author(s):  
Kenji SASAKI ◽  
Kayo SUGIYAMA ◽  
Masanori KODA ◽  
Shuji YONEHARA
Keyword(s):  
Pancreatic Juice ◽  
Intraepithelial Neoplasia ◽  
Pancreatic Intraepithelial Neoplasia ◽  
Cytologic Diagnosis ◽  
Endoscopic Nasopancreatic Drainage ◽  
Nasopancreatic Drainage

Intestinal Heterotopic Pancreas Involved by Simultaneous PanIN-2 Lesion and Endocrine Microadenoma: a Unique Case

2017 ◽  
Vol 26 (2) ◽  
pp. 199-202
Author(s):  
Remus Cornea ◽  
Sorina Taban ◽  
Cristian Suciu ◽  
Codruta Lazureanu ◽  
Alis Dema
Keyword(s):  
Histopathological Examination ◽  
Intraepithelial Neoplasia ◽  
Heterotopic Pancreas ◽  
Pancreatic Intraepithelial Neoplasia ◽  
Unique Case ◽  
Intraductal Papillary Mucinous Neoplasms ◽  
Pancreatic Endocrine Neoplasm ◽  
First Case ◽  
Mucinous Neoplasms

We hereby present the case of a 58-year-old male who underwent a total gastrectomy for gastric neoplasm. During the surgery, a tumor mass in the jejunum was identified, considered as metastasis, and resected. The histopathological examination of the jejunal lesion showed ectopic pancreas. In this area, two pathological distinct lesions were identified, one histologically compatible with pancreatic intraepithelial neoplasia (PanIN) type 2 lesion and the other with morphologic criteria for endocrine microadenoma. To our knowledge, this is the first case that evidences the presence of a concomitant premalignant exocrine lesion and benign endocrine lesion in a heterotopic pancreas (HP).Abbreviations: HP: heterotopic pancreas; IPMN: Intraductal Papillary Mucinous Neoplasms; PanIN: Pancreatic Intraepithelial Neoplasia; PEN: pancreatic endocrine neoplasm.

BRCA2 Dysfunction Promotes Malignant Transformation of Pancreatic Intraepithelial Neoplasia

2013 ◽  
Vol 13 (2) ◽  
pp. 261-269 ◽  
Author(s):  
Qi Wang ◽  
Hongrui Liu ◽  
Tingting liu ◽  
Shizhen Shu ◽  
He Jiang ◽  
...  
Keyword(s):  
Malignant Transformation ◽  
Intraepithelial Neoplasia ◽  
Pancreatic Intraepithelial Neoplasia

Pancreatic Intraepithelial Neoplasia

2001 ◽  
Vol 25 (5) ◽  
pp. 579-586 ◽  
Author(s):  
Ralph H. Hruban ◽  
N. Volkan Adsay ◽  
Jorge Albores–Saavedra ◽  
Carolyn Compton ◽  
Elizabeth S. Garrett ◽  
...  
Keyword(s):  
Intraepithelial Neoplasia ◽  
Pancreatic Intraepithelial Neoplasia

scholarly journals Successful combination strategy of preoperative placement of an endoscopic nasopancreatic drainage catheter and pancreas preservation surgery for pancreatic injury with major pancreatic duct disruption: a case report

2019 ◽  
Vol 5 (1) ◽  
Author(s):  
Kenji Kandori ◽  
Wataru Ishii ◽  
Ryoji Iizuka
Keyword(s):  
Pancreatic Duct ◽  
Pancreatic Resection ◽  
Pancreatic Injury ◽  
Combination Strategy ◽  
Pancreatic Body ◽  
First Case ◽  
Endoscopic Nasopancreatic Drainage ◽  
Pancreas Preservation ◽  
Nasopancreatic Drainage ◽  
Grade Iii

Abstract Background The guidelines recommend pancreatic resection for grade III and IV pancreatic injuries. On the other hand, organ preservation is an important issue. Herein, we present the first case of pancreatic injury with major pancreatic duct (MPD) disruption that was treated with the combination of preoperative placement of endoscopic nasopancreatic drainage (ENPD) catheter and pancreas preservation surgery after endoscopic pancreatic stenting (EPS) failure. Case presentation A 70-year-old female diagnosed with pancreatic injury was admitted to our hospital. She was hemodynamically stable. ERP revealed MPD disruption, and EPS failed. An ENPD catheter was placed preoperatively at the site of injury. During laparotomy, we identified a partial-thickness laceration in the pancreatic body. At the site of injury, the tip of the ENPD catheter was found; therefore, the patient was diagnosed with grade III pancreatic body injury with MPD disruption. The extent of crush was not severe, and we had no difficulty in identifying the distal MPD segment. We inserted the ENPD catheter into the distal MPD segment. The ruptured MPD and the laceration was sutured, then pancreatic resection was prevented. She was discharged on POD 56. Conclusion The treatment strategy incorporated ERP, placement of an ENPD catheter preoperatively, and a simple surgery in a hemodynamically stable patient with pancreatic injury allows the pancreas and spleen to be preserved.

scholarly journals Senolytic elimination of Cox2-expressing senescent cells inhibits the growth of premalignant pancreatic lesions

Gut ◽  
2021 ◽  
pp. gutjnl-2020-321112
Author(s):  
Dror Kolodkin-Gal ◽  
Lior Roitman ◽  
Yossi Ovadya ◽  
Narmen Azazmeh ◽  
Benjamin Assouline ◽  
...  
Keyword(s):  
Tumour Growth ◽  
Precancerous Lesions ◽  
Intraepithelial Neoplasia ◽  
Preventive Therapy ◽  
Ductal Adenocarcinoma ◽  
Potential Contribution ◽  
Pancreatic Intraepithelial Neoplasia ◽  
Promoting Effect ◽  
Paracrine Effects ◽  
Bcl2 Family

ObjectiveCellular senescence limits tumourigenesis by blocking the proliferation of premalignant cells. Additionally, however, senescent cells can exert paracrine effects influencing tumour growth. Senescent cells are present in premalignant pancreatic intraepithelial neoplasia (PanIN) lesions, yet their effects on the disease are poorly characterised. It is currently unknown whether senolytic drugs, aimed at eliminating senescent cells from lesions, could be beneficial in blocking tumour development.DesignTo uncover the functions of senescent cells and their potential contribution to early pancreatic tumourigenesis, we isolated and characterised senescent cells from PanINs formed in a Kras-driven mouse model, and tested the consequences of their targeted elimination through senolytic treatment.ResultsWe found that senescent PanIN cells exert a tumour-promoting effect through expression of a proinflammatory signature that includes high Cox2 levels. Senolytic treatment with the Bcl2-family inhibitor ABT-737 eliminated Cox2-expressing senescent cells, and an intermittent short-duration treatment course dramatically reduced PanIN development and progression to pancreatic ductal adenocarcinoma.ConclusionsThese findings reveal that senescent PanIN cells support tumour growth and progression, and provide a first indication that elimination of senescent cells may be effective as preventive therapy for the progression of precancerous lesions.

scholarly journals Acute obstructive suppurative pancreatic ductitis in pancreatic malignancies

2020 ◽  
Vol 08 (12) ◽  
pp. E1765-E1768
Author(s):  
Ryoko Shimizuguchi ◽  
Masataka Kikuyama ◽  
Terumi Kamisawa ◽  
Sawako Kuruma ◽  
Kazuro Chiba
Keyword(s):  
Abdominal Pain ◽  
Pancreatic Duct ◽  
Pancreatic Juice ◽  
Myelogenous Leukemia ◽  
Ductal Adenocarcinoma ◽  
Klebsiella Pneumonia ◽  
Duct Obstruction ◽  
Pancreatic Duct Obstruction ◽  
Nasopancreatic Drainage ◽  
Accessory Pancreatic Duct

Abstract Background and study aims Acute obstructive suppurative pancreatic ductitis (AOSPD) is a suppurative pancreatic duct infection with main pancreatic duct (MPD) or accessory pancreatic duct obstruction in the absence of a pancreatic pseudocyst or necrosis, which is experienced usually in chronic pancreatitis. The diagnosis is confirmed by the finding of pancreatic duct obstruction on endoscopic retrograde cholangiopancreatography (ERCP) with evidence of infection, such as a positive pancreatic juice culture or drainage of purulent pancreatic juice. Patients and methods We studied five patients with pancreatic ductal adenocarcinoma (PDAC) and one with chronic myelogenous leukemia (CML), who suffered from AOSPD. Results Of the 281 PDAC and 39 CML patients who we treated in the past 2 years in our hospital, five with PDAC (1.8 %) and one with CML (2.6 %) experienced AOSPD. Each patient had fever, abdominal pain, and increased blood C-reactive protein. Pancreatography found that each patient had a MPD stricture and an upstream dilatation. Four had a disruption of the MPD in the upper stream of the stricture. Nasopancreatic drainage was successfully performed in all patients. Pancreatic juice culture was positive for Klebsiella pneumonia, Enterobacter agerogenes, or Enterococcus cloacae in four patients. Conclusion AOSPD should be considered in pancreatic malignancy with fever and abdominal pain. Prompt diagnosis of AOSPD could avoid shortening of survival of patients with an already poor prognosis by infection.

Association of aging and ARHGAP17 variation with pancreatic intraepithelial neoplasia

Pancreatology ◽  
2016 ◽  
Vol 16 (1) ◽  
pp. S14
Author(s):  
Y. Matsuda ◽  
M. Tanaka ◽  
A. Suzuki ◽  
A. Seki ◽  
K. Nonaka ◽  
...  
Keyword(s):  
Intraepithelial Neoplasia ◽  
Pancreatic Intraepithelial Neoplasia
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