A case of clear cell renal cell carcinoma with metastasis to the skeletal muscle, diagnosed by needle aspiration cytology

2016 ◽  
Vol 55 (5) ◽  
pp. 340-344
Author(s):  
Kaori TAKESHITA ◽  
Tsubasa HIRAKI ◽  
Emi KUBOTA ◽  
Yukari NISHIDA ◽  
Kazuhiko TANAKA ◽  
...  
Keyword(s):  
Skeletal Muscle ◽  
Renal Cell Carcinoma ◽  
Cell Carcinoma ◽  
Renal Cell ◽  
Clear Cell ◽  
Needle Aspiration ◽  
Aspiration Cytology ◽  
Cell Renal Cell Carcinoma ◽  
Needle Aspiration Cytology

A Pilot Study Evaluating Fine-Needle Aspiration Cytology of Clear-Cell Renal Cell Carcinoma: Comparison of Ancillary Immunocytochemistry and Cytomorphological Characteristics of SurePath™ Liquid-Based Preparations with Conventional Smears

2015 ◽  
Vol 59 (3) ◽  
pp. 239-247 ◽  
Author(s):  
Chung Hun Lee ◽  
Soo Young Chung ◽  
Kyung Chul Moon ◽  
In Ae Park ◽  
Yul Ri Chung ◽  
...  
Keyword(s):  
Renal Cell Carcinoma ◽  
Cell Carcinoma ◽  
Fine Needle Aspiration ◽  
Renal Cell ◽  
Fine Needle Aspiration Cytology ◽  
Clear Cell ◽  
Needle Aspiration ◽  
Aspiration Cytology ◽  
Fine Needle ◽  
Needle Aspiration Cytology

Objective: Fine-needle aspiration cytology (FNAC) based on a liquid-based preparation is a safe and valuable diagnostic tool. However, due to unfamiliarity with this method and the considerably altered morphology that is associated with it, diagnosing renal cell carcinoma (RCC) from this type of preparation remains a challenge for cytopathologists. The aim of this study was to evaluate the cytomorphological characteristics of SurePath™ (SP)-based preparations compared with conventional smear (CS), and also the role of SP-based FNAC in the diagnosis of clear-cell RCC (CRCC), the most common primary renal malignancy. Study Design: Ex vivo FNAC of both tumors and normal renal parenchyma was prepared from 73 cases. Comparative cytomorphological analysis between liquid-based cytology (LBC) and CS as well as Fuhrman nuclear grading (FNG) was carried out. Immunocytochemistry was performed from normal and CRCC cytology specimens. Results: Normal renal cytology (NRC) showed no significant morphological differences between LBC and CS. For CRCC, LBC showed small, fragmented cell clusters, a 3-dimensional configuration, distinct cytoplasmic vacuoles, and irregular nuclear contours when compared with CS. FNG was overgraded with LBC compared to with CS. AMACR was the most valuable immunocytochemical marker for distinguishing CRCC from NRC. Conclusion: Once cytopathologists become familiar with the altered cytomorphological features of CRCC, FNAC, along with immunocytochemistry, may prove helpful for diagnosis.

scholarly journals Solitary Intrathyroid Metastasis Occurring 23 Years after Resection of Renal Cell Carcinoma

2021 ◽  
Vol 2021 ◽  
pp. 1-3
Author(s):  
X. Vandemergel
Keyword(s):  
Renal Cell Carcinoma ◽  
Cell Carcinoma ◽  
Renal Cell ◽  
Needle Aspiration ◽  
Thyroid Lobe ◽  
Aspiration Cytology ◽  
History Of ◽  
Right Lobe ◽  
Needle Aspiration Cytology ◽  
The Right

A case of solitary intrathyroid metastasis is described in a 60-year-old male patient. He had a history of renal cell carcinoma classified as T1b resected 23 years earlier. A mass was palpable in the right thyroid lobe. Ultrasound showed a hypoechoic polylobular nodule with intense vascularisation in the right lobe. Fine needle aspiration cytology was normal, but thyroidectomy was performed due to mass enlargement, the ultrasound pattern, and the oncological history. Histological examination revealed the presence of an intrathyroid metastasis of renal cell carcinoma. The bone scan and thoracoabdominal CT scan were normal. Postoperative care was uneventful.

scholarly journals FNAC Diagnosis of eosinophilic variant of chromophobe renal cell carcinoma – A challenge for cytopathologists

2021 ◽  
Vol 6 (4) ◽  
pp. 283-287
Author(s):  
Jaydeep N Pol ◽  
Neha M Bhosale ◽  
Girish A Kadkol ◽  
Madhura D Phadke ◽  
Swpana S Magdum
Keyword(s):  
Renal Cell Carcinoma ◽  
Cell Carcinoma ◽  
Renal Cell ◽  
Needle Aspiration ◽  
Chromophobe Renal Cell Carcinoma ◽  
Cellular Heterogeneity ◽  
Renal Oncocytoma ◽  
Cell Renal Cell Carcinoma ◽  
Extent Of Surgery ◽  
Needle Aspiration Cytology

Chromophobe Renal Cell Carcinoma (ChRCC) is a rare distinct subtype of Renal cell carcinoma. It arises from intercalated cells of the renal cortex. The cytomorphological features of ChRCC show significant overlap with Clear cell Renal Cell Carcinoma (CCRCC) and Oncocytoma. The prognosis of ChRCC is intermediate between benign Renal Oncocytoma and the relatively aggressive CCRCC. Hence, a correct pre or intra-operative cytodiagnosis helps in deciding the extent of surgery. We report a case of eosinophilic variant of ChRCC in a 70 years female, diagnosed on Fine Needle Aspiration Cytology (FNAC).The Immunocytochemistry (ICC), histology and Immunohistochemistry confirmed the diagnosis of ChRCC. Diagnosing ChRCC; especially its eosinophilic variant on FNAC is very challenging. Prominent cellular heterogeneity, pleomorphism, perinuclear halos and binucleation are important diagnostic clues for cytodiagnosis of ChRCC. In difficult cases, ICC helps in confirming the diagnosis.

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