scholarly journals Intranuclear cytoplasmic inclusions in benign thyroid lesions.

1993 ◽  
Vol 32 (6) ◽  
pp. 833-839 ◽  
Author(s):  
Junko MARUTA
Keyword(s):  
Cytoplasmic Inclusions ◽  
Intranuclear Cytoplasmic Inclusions ◽  
Benign Thyroid ◽  
Thyroid Lesions

scholarly journals Shared and unique metabolic features of the malignant and benign thyroid lesions determined with use of 1H HR MAS NMR spectroscopy

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Agnieszka Skorupa ◽  
Mateusz Ciszek ◽  
Ewa Chmielik ◽  
Łukasz Boguszewicz ◽  
Małgorzata Oczko-Wojciechowska ◽  
...  
Keyword(s):  
Nmr Spectra ◽  
Univariate Analysis ◽  
Mas Nmr ◽  
Metabolic Reprogramming ◽  
Benign Lesions ◽  
Chronic Thyroiditis ◽  
Malignant Lesions ◽  
Metabolic Heterogeneity ◽  
Benign Thyroid ◽  
Thyroid Lesions

AbstractThe purpose of this work was to investigate the distinct and common metabolic features of the malignant and benign thyroid lesions in reference to the non-transformed tissue from the contralateral gland (chronic thyroiditis and colloid goiter). 1H HR MAS NMR spectra of 38 malignant lesions, 32 benign lesions and 112 samples from the non-tumoral tissue (32 from chronic thyroiditis and 80 samples from colloid goiter) were subjected both to multivariate and univariate analysis. The increased succinate, glutamine, glutathione, serine/cysteine, ascorbate, lactate, taurine, threonine, glycine, phosphocholine/glycerophosphocholine and decreased lipids were found in both lesion types in comparison to either colloid goiter or chronic thyroiditis. The elevated glutamate and choline, and reduced citrate and glucose were additionally evident in these lesions in reference to goiter, while the increased myo-inositol—in comparison to thyroiditis. The malignant lesions were characterized by the higher alanine and lysine levels than colloid goiter and thyroiditis, while scyllo-inositol was uniquely increased in the benign lesions (not in cancer) in comparison to both non-tumoral tissue types. Moreover, the benign lesions presented with the unique increase of choline in reference to thyroiditis (not observed in the cancerous tissue). The metabolic heterogeneity of the non-tumoral tissue should be considered in the analysis of metabolic reprogramming in the thyroid lesions.

scholarly journals Thyroid Transcription Factor � 1 (TTF-1) Immunoexpression in Thyroid Carcinoma with Follicular Origin

2001 ◽  
Vol 71 (3) ◽  
pp. 185-191
Author(s):  
Amadeus Dobrescu ◽  
Cristi Tarta ◽  
Marioara Cornianu ◽  
Codruta Lazureanu ◽  
Ioana Golu ◽  
...  
Keyword(s):  
Transcription Factor ◽  
Recurrent Disease ◽  
Clinical Behavior ◽  
Thyroid Carcinomas ◽  
Nuclear Expression ◽  
Thyroid Transcription Factor 1 ◽  
Thyroid Transcription Factor ◽  
Transcription Factor 1 ◽  
Benign Thyroid ◽  
Thyroid Lesions

Differentiated thyroid carcinomas are heterogeneous diseases with clinical and morphological features insufficient to predict their clinical behavior. The expression of tissue-specific transcription factors that control differentiated phenotype can be an additional method in evaluating the aggressiveness of a tumor, when differentiation markers and malignant phenotype of tumor cells are inconclusive. The expression of thyroid transcription factor-1 (TTF-1) is limited to thyroid follicular cells; it is a nuclear protein expressed in the epithelial cells of the thyroid, lungs and diencephalon. Using the monoclonal mouse antibody, clone 8G7G3/1, we examined the immunohistochemical expression of TTF-1 protein in 26 thyroid carcinomas (22 papillary carcinomas � PTC, 2 follicular carcinomas � FTC, 2 anaplastic carcinomas - AC), 4 follicular adenomas � FA, 10 benign thyroid lesions as underlying diseases (multinodular goiter � 3, Hashimoto thyroiditis � 3, Graves Basedow disease - 4) and sections of normal thyroid tissue, assessing the possible correlations with clinical and morphological features, as well as patient outcomes.TTF-1 nuclear expression was identified in 75% of benign thyroid lesions and 18/26 (69.23%) carcinomas. We noted TTF-1 nuclear expression in 68.18% of PTC (10% being associated with recurrent disease) and the absence of immunoreaction in 31.82% of PTC without recurrent disease. In patients with PTC, the risk of recurrence was significantly associated with the presence of nuclear TTF-1 expression in the primary tumor (p[0.001), but was not influenced by the type of surgery performed (p]0.05) or patients� age. TTF-1 nuclear expression did not correlate with patients� gender, tumor size, extent of disease at the moment of diagnosis and multifocal tumors (p]0.05). TTF-1 nuclear reactivity can be elevated in differentiated thyroid tumors (PTC and FTC) with aggressive clinical behavior that will develop recurrent or persistent disease. In anaplastic thyroid carcinomas with fast growth rate, immunoreactivity for TTF-1 and Ki-67 can offer useful information for tumor cell differentiation, while in the case of a mixed thyroid tumor it helps in distinguishing between well differentiated and undifferentiated/anaplastic areas.

Intranuclear cytoplasmic inclusions in gastric leiomyosarcoma

1998 ◽  
Vol 18 (6) ◽  
pp. 475-476 ◽  
Author(s):  
Tadao K. Kobayashi ◽  
Makoto Katoh ◽  
Shinsuke Watanabe ◽  
Chiyuki Kaneko
Keyword(s):  
Cytoplasmic Inclusions ◽  
Intranuclear Cytoplasmic Inclusions ◽  
Gastric Leiomyosarcoma

Significance of intranuclear cytoplasmic inclusions in malignant pleural effusion

2008 ◽  
Vol 36 (7) ◽  
pp. 531-533 ◽  
Author(s):  
Chiyuki Kaneko ◽  
Kazuo Kato ◽  
Tadao K. Kobayashi ◽  
Hirofumi Sakamoto
Keyword(s):  
Pleural Effusion ◽  
Malignant Pleural Effusion ◽  
Cytoplasmic Inclusions ◽  
Intranuclear Cytoplasmic Inclusions

Intranuclear cytoplasmic inclusions in cytologically suspicious or malignant thyroid nodules: identification and correlation with echogenicity and size of the nodules

Endocrine ◽  
2013 ◽  
Vol 46 (1) ◽  
pp. 114-122
Author(s):  
Salvatore Arena ◽  
Adele Latina ◽  
Michele Stornello ◽  
Giovanna Saraceno ◽  
Salvatore Benvenga
Keyword(s):  
Thyroid Nodules ◽  
Cytoplasmic Inclusions ◽  
Intranuclear Cytoplasmic Inclusions

Monosomy and ring chromosome 13 in a thyroid nodular goiter—do we underestimate its relevance in benign thyroid lesions?

2012 ◽  
Vol 205 (3) ◽  
pp. 128-130 ◽  
Author(s):  
Wolfgang Sendt ◽  
Volkhard Rippe ◽  
Inga Flor ◽  
Norbert Drieschner ◽  
Jörn Bullerdiek
Keyword(s):  
Nodular Goiter ◽  
Ring Chromosome ◽  
Chromosome 13 ◽  
Benign Thyroid ◽  
Thyroid Lesions
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