scholarly journals Management of severe dysplasia and carcinoma in situ (CIS) during pregnancy.

1993 ◽  
Vol 32 (4) ◽  
pp. 489-494
Author(s):  
Yusuke MATSUURA ◽  
Toshinori KAWAGOE ◽  
Michioki SHINOHARA ◽  
Masamichi KASHIMURA
Keyword(s):  
Carcinoma In Situ ◽  
Severe Dysplasia

Probability of Transition of Normal Esophageal Mucosa and Precancerous Lesion to the Esophageal Cancer

2021 ◽  
Author(s):  
Zhiyu Chen ◽  
Yong YU ◽  
Xue YANG ◽  
Jing-Xuan WANG ◽  
Wen-Qiang Wei ◽  
...  
Keyword(s):  
Esophageal Cancer ◽  
Carcinoma In Situ ◽  
Markov Models ◽  
Transition Probabilities ◽  
Health State ◽  
Severe Dysplasia ◽  
Esophageal Mucosa ◽  
Mild Dysplasia ◽  
Pathological Stages

Abstract Background: To estimate the transition probabilities of esophageal cancer（EC） and its precancerous lesions by Markov model, which could provide important information for EC screening about choosing reasonable screening and follow-up intervals.Methods: The transition probabilities among pathological stages were estimated by establishing Markov models for the natural history of EC and repeatedly adjusting and calibrating Markov models by comparing the modeled incidence and distributions of pathological stages (alone or combined) with observed data in real-world condition. Results: In one year, the probabilities were 0.024, 0.05, 0.12 for people from health state progressing to mild dysplasia (mD), mild dysplasia (mD) to moderate dysplasia (MD), and moderate dysplasia (MD) to severe dysplasia/carcinoma in situ (SD/CIS), respectively. The age-specific transition probabilities were 0.08~0.18 for severe dysplasia/carcinoma in situ (SD/CIS) progressing to intramucosal carcinoma(IC), 0.4~0.87 for intramucosal carcinoma (IC) to submucosal carcinoma (T1N0M0) (SC), and 0.2~0.85 for submucosal carcinoma (T1N0M0) (SC) to invasive carcinoma (INC). The progression probabilities increased with age and the severity of the disease. Based on the estimated transition probabilities, we predicted the incidence of EC and distributions of its pathological stages. Comparisons between modeled results with observed data confirmed the validation of our transition probabilities.Conclusions: An esophageal cancer transition model in high-risk areas of China has been established with validity. It could be a point of reference for further economic evaluation and policy formulation of esophageal cancer screening.

Laryngeal Dysplasia: Epidemiology and Treatment Outcome

1995 ◽  
Vol 104 (8) ◽  
pp. 596-602 ◽  
Author(s):  
Keith E. Blackwell ◽  
Thomas C. Calcaterra ◽  
Yao-Shi Fu
Keyword(s):  
Treatment Group ◽  
Carcinoma In Situ ◽  
Invasive Carcinoma ◽  
Endoscopic Therapy ◽  
Partial Laryngectomy ◽  
Severe Dysplasia ◽  
Long Term Follow Up

A retrospective analysis was undertaken of 65 patients with long-term follow-up for laryngeal squamous dysplasia. Based on the degree of dysplasia demonstrated on initial biopsy, 0 of 6 patients showing hyperkeratosis without dysplasia, 3 of 26 patients (12%) showing mild dysplasia, 5 of 15 patients (33%) showing moderate dysplasia, 4 of 9 patients (44%) showing severe dysplasia, and 1 of 9 patients (11%) showing carcinoma in situ eventually progressed to invasive carcinoma. An analysis was made of the impact of various treatment modalities in 33 patients demonstrating moderate dysplasia, severe dysplasia, or carcinoma in situ. Invasive carcinoma developed in 10 of 21 patients (48%) treated endoscopically and 0 of 12 patients treated by more aggressive therapy, including external beam radiotherapy, partial laryngectomy, or total laryngectomy. Of the patients in the endoscopic therapy group who developed invasive carcinoma, all were salvaged successfully. The overall rate of laryngeal preservation was 15 of 21 patients (71%) in the endoscopic treatment group and 11 of 12 patients (92%) in the aggressive treatment group. This difference is not statistically significant. We conclude that there is a moderately high rate of progression to invasive carcinoma in patients undergoing repeated endoscopic therapy for intraepithelial neoplasms of the larynx. However, with close, long-term follow-up, patients undergoing endoscopic therapy have an overall outcome similar to that in patients treated with partial laryngectomy or radiotherapy prior to developing invasive disease.

scholarly journals PORT SITE RECURRENCE OF GALLBLADDER CARCINOMA IN SITU INITIALLY DIAGNOSED AS SEVERE DYSPLASIA

2008 ◽  
Vol 69 (2) ◽  
pp. 427-432 ◽  
Author(s):  
Kenjiro HIRAI ◽  
Tsuyoshi TERASHIMA ◽  
Shinichi HOSOKAWA ◽  
Kazuo ONO ◽  
Eiji TAKEUCHI ◽  
...  
Keyword(s):  
Gallbladder Carcinoma ◽  
Carcinoma In Situ ◽  
Port Site ◽  
Severe Dysplasia ◽  
Port Site Recurrence

Estimation of The Transitional Probability Among Esophageal Cancer and Its Precancerous Lesions

2020 ◽  
Author(s):  
Yong YU ◽  
Yue XIE ◽  
Xue YANG ◽  
Jing-Xuan WANG ◽  
Zhi-Yu CHEN ◽  
...  
Keyword(s):  
Esophageal Cancer ◽  
Carcinoma In Situ ◽  
Markov Models ◽  
Transition Probabilities ◽  
Precancerous Lesions ◽  
Health State ◽  
Severe Dysplasia ◽  
Mild Dysplasia ◽  
Pathological Stages

Abstract Background: To estimate the transition probabilities of esophageal cancer (EC) and its precancerous lesions during the process of canceration by Markov model, which could provide important information for EC screening with regard to choosing reasonable screening and follow-up intervals.Methods: The transition probabilities among pathological stages were estimated by establishing Markov models for the natural history of EC and repeatedly adjusting and calibrating Markov models through comparing the modeled incidence and distributions of pathological stages (alone or combined) with observed data in real world condition. Results: In one year, the probabilities were 0.024, 0.05, 0.12 for people from health state progressing to mild dysplasia (mD), mild dysplasia (mD) to moderate dysplasia (MD), and moderate dysplasia (MD) to severe dysplasia/carcinoma in situ (SD/CIS), respectively. The age-specific transition probabilities were 0.08~0.18 for severe dysplasia/carcinoma in situ (SD/CIS) progressing to intramucosal carcinoma(IC), 0.4~0.87 for intramucosal carcinoma (IC) to submucosal carcinoma (T1N0M0) (SC), and 0.2~0.85 for submucosal carcinoma (T1N0M0) (SC) to invasive carcinoma (INC). The progression probabilities increased with age and the severity of the disease. Based on the estimated transition probabilities, we predicted the incidence of EC and distributions of its pathological stages. Comparisons between modeled results with observed data confirmed the validation of our transition probabilities.Conclusion: The estimating transition probabilities of EC and its precancerous lesions were reliable and could be used to address questions such as the optimal screening frequency, screening intervals, and health economic evaluation of screening strategies.

scholarly journals Long-Term Follow-Up of Severe Dysplasia and Carcinoma In Situ of the Bronchus

2009 ◽  
Vol 4 (9) ◽  
pp. 1187-1188 ◽  
Author(s):  
Mathieu Salaün ◽  
Suzanna Bota ◽  
Luc Thiberville
Keyword(s):  
Carcinoma In Situ ◽  
Severe Dysplasia ◽  
Long Term Follow Up

scholarly journals Cytology of severe dysplasia, carcinoma in situ, and minimal invasive carcinoma of the uterine cervix

1971 ◽  
Vol 10 (2) ◽  
pp. 242-246
Author(s):  
Masahiro Nakayama ◽  
Kimio Suzuki ◽  
Kenji Soejima ◽  
Mamoru Shimomura ◽  
Eizoo Fukuda ◽  
...  
Keyword(s):  
Uterine Cervix ◽  
Carcinoma In Situ ◽  
Invasive Carcinoma ◽  
Minimal Invasive ◽  
Severe Dysplasia
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