scholarly journals Occurence and frequency of intranuclear cytoplasmic inclusions, nuclear grooves and psammoma bodies in fine needle aspirates of thyroid nodules.

1990 ◽  
Vol 29 (6) ◽  
pp. 813-818
Author(s):  
Minoru MATSUDA ◽  
Naomi YAMATO ◽  
Akira WADA
Keyword(s):  
Thyroid Nodules ◽  
Psammoma Bodies ◽  
Cytoplasmic Inclusions ◽  
Fine Needle ◽  
Fine Needle Aspirates ◽  
Intranuclear Cytoplasmic Inclusions

Incidence and Predictive Factors of Inadequate Fine-Needle Aspirates forBRAFV600EMutation Analysis in Thyroid Nodules

2014 ◽  
Vol 202 (2) ◽  
pp. 391-396 ◽  
Author(s):  
Kwang Hwi Lee ◽  
Hyun Su Kim ◽  
Boo-Kyung Han ◽  
Eun Young Ko ◽  
Chang-Seok Ki ◽  
...  
Keyword(s):  
Predictive Factors ◽  
Thyroid Nodules ◽  
Fine Needle ◽  
Fine Needle Aspirates

Intranuclear cytoplasmic inclusions in cytologically suspicious or malignant thyroid nodules: identification and correlation with echogenicity and size of the nodules

Endocrine ◽  
2013 ◽  
Vol 46 (1) ◽  
pp. 114-122
Author(s):  
Salvatore Arena ◽  
Adele Latina ◽  
Michele Stornello ◽  
Giovanna Saraceno ◽  
Salvatore Benvenga
Keyword(s):  
Thyroid Nodules ◽  
Cytoplasmic Inclusions ◽  
Intranuclear Cytoplasmic Inclusions

Thyroid peroxidase immunodetection as a tool to assist diagnosis of thyroid nodules on fine-needle aspiration biopsy

1994 ◽  
Vol 131 (5) ◽  
pp. 474-479 ◽  
Author(s):  
Catherine De Micco ◽  
Patricia Zoro ◽  
Stéphane Garcia ◽  
Lambert Skoog ◽  
Edneia M Tani ◽  
...  
Keyword(s):  
Monoclonal Antibody ◽  
Fine Needle Aspiration ◽  
Thyroid Nodules ◽  
Malignant Tumors ◽  
Needle Aspiration ◽  
Aspiration Biopsy ◽  
Thyroid Peroxidase ◽  
Fine Needle ◽  
Fine Needle Aspirates ◽  
Benign Nodules

De Micco C, Zoro P, Garcia S, Skoog L, Tani EM, Carayon P, Henry J-F. Thyroid peroxidase immunodetection as a tool to assist diagnosis of thyroid nodules on fine-need aspiration biopsy. Eur J Endocrinol 1994;131:474–9. ISSN 0804–4643 In a previous work we have reported the presence in 96.9% of malignant and 4.2% of benign thyroid tumors of an immunological abnormality of the enzyme thyroid peroxidase, impeding the fixation of the anti-thyroid peroxidase monoclonal antibody termed "MoAb47". The present study has been designed to establish the ability of thyroid peroxidase immunodetection to assist the diagnosis of malignancy in fine-needle aspiration of thyroid nodules. The fixation of anti-thyroid peroxidase monoclonal antibody was investigated by immunohistochemistry on fine-needle aspirates of 150 surgically removed thyroid nodules (20 papillary carcinomas, five follicular carcinomas, 90 colloid adenomas, nine fetal adenoma, 13 atypical adenomas, five oncocytic adenomas, six Hashimoto's thyroiditis and two Graves' disease). The percentage of positive cells has been compared to the final histological diagnosis. In samples from 113/125 benign nodules 80–100% cells presented a positive immunoreaction, whereas all samples from malignant tumors yielded less than 80% positive cells. Benign nodules exhibiting less than 80% positive cells corresponded to three degenerative colloid nodules, five atypical follicular adenomas, two oncocytomas and two thyroiditis. According to results obtained in this series, with the value of 80% as the limit for discrimination between benign and highrisk nodules, the sensitivity of thyroid peroxidase staining for diagnosis of malignancy would be 100%, its specificity 90% and its overall accuracy 92%. Thyroid peroxidase staining with monoclonal antibody MoAb47 on fine-needle aspirates is a useful adjunct to conventional cytology for the investigation of patients with thyroid nodules. Catherine De Micco, Laboratoire d'Anatomie Pathologique, Faculté de Médecine Nord, Bd Pierre Dramard, 13916 Marseille Cedex 20, France

Immediate Assessment of Fine Needle Aspirates of Thyroid Nodules by Telecytopathology

2011 ◽  
pp. P1-705-P1-705
Author(s):  
Rohini Kasturi ◽  
Kamal K Khurana ◽  
Rachel Hopkins ◽  
Ismatun Swati ◽  
Roberto Izquierdo
Keyword(s):  
Thyroid Nodules ◽  
Fine Needle ◽  
Fine Needle Aspirates

BRAF V600E assessment by pyrosequencing in fine needle aspirates of thyroid nodules with concurrent Hashimoto’s thyroiditis is a reliable assay

Endocrine ◽  
2013 ◽  
Vol 45 (2) ◽  
pp. 249-255 ◽  
Author(s):  
Anna Guerra ◽  
Vincenza Di Stasi ◽  
Pio Zeppa ◽  
Antongiulio Faggiano ◽  
Vincenzo Marotta ◽  
...  
Keyword(s):  
Hashimoto’S Thyroiditis ◽  
Thyroid Nodules ◽  
Braf V600e ◽  
Hashimoto's Thyroiditis ◽  
Fine Needle ◽  
Fine Needle Aspirates

scholarly journals Assessment ofSPAG9Transcript in Fine Needle Aspirates of Thyroid Nodules

2012 ◽  
Vol 1 (2) ◽  
pp. 118-121 ◽  
Author(s):  
Bertrand Volard ◽  
Sophie Krieger ◽  
Gaétane Planchard ◽  
Agnès Hardouin ◽  
Dominique Vaur ◽  
...  
Keyword(s):  
Thyroid Nodules ◽  
Fine Needle ◽  
Fine Needle Aspirates

scholarly journals Diagnostic performance of Midkine ratios in fine-needle aspirates for evaluation of Cytologically indeterminate thyroid nodules

2021 ◽  
Vol 16 (1) ◽  
Author(s):  
Le Zhou ◽  
Jinxi Jiang ◽  
Yantao Fu ◽  
Daqi Zhang ◽  
Tong Li ◽  
...  
Keyword(s):  
Thyroid Nodules ◽  
Area Under The Curve ◽  
Needle Aspiration ◽  
Enzyme Linked Immunosorbent Assay ◽  
Tumor Diameter ◽  
Papillary Thyroid ◽  
Cutoff Value ◽  
Fine Needle ◽  
Thyroid Carcinomas ◽  
Fine Needle Aspirates

Abstract Background Fine-needle aspiration cytology (FNAC) is a basic diagnostic tool for thyroid nodules. However, 15–30% of nodules are cytologically indeterminate. Midkine (MK), a pleiotropic growth factor, is often upregulated in patients with cancers. This study aimed to evaluate the role of MK and its ratios in fine-needle aspirates (FNA) for predicting thyroid malignancy. Methods This retrospective study included patients with thyroid nodules who underwent preoperative FNA and/or thyroidectomy between April 2017 and September 2017. MK levels in FNA washout were measured by enzyme-linked immunosorbent assay, and thyroglobulin (TG) and free thyroxine (FT4) levels in FNA washout were measured by chemiluminescent immunometric assays. Results A total of 217 patients with 242 nodules were included in this study. The concentrations of TG, FT4, MK/TG, MK/FT4, and FT4/MK were significantly different between papillary thyroid carcinomas and benign thyroid nodules. Both MK/TG and MK/FT4 ratios were positively correlated with maximum tumor diameter, extrathyroidal extension, and T and N stages. The area under the curve for MK/TG was 0.719 with a cutoff value of 55.57 ng/mg, while the area under the curve for MK/FT4 was 0.677 with a cutoff value of 0.11 μg/pmol. FNAC in combination with MK/FT4 had a higher sensitivity (95% vs. 91%) and accuracy (96% vs. 92%) than FNAC alone for cytologically indeterminate specimens, those of unknown significance, or those suspected of malignancy. Conclusions MK/FT4 and MK/TG may have diagnostic utility for evaluation of papillary thyroid carcinomas, particularly for cytologically indeterminate thyroid nodules.

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