scholarly journals Omental milky spot and peritoneal macrophage. Characteristics, function and ontogeny.

1987 ◽  
Vol 26 (4) ◽  
pp. 572-580 ◽  
Author(s):  
Yutaka IMAI ◽  
Mitsunori YAMAKAWA ◽  
Kunihiko MAEDA ◽  
Akihiro MASUDA ◽  
Toshi-hiro SATO
Keyword(s):  
Peritoneal Macrophage ◽  
Milky Spot ◽  
Omental Milky Spot

Macrophage Inhibition of Collagen-Induced Platelet Aggregation

1979 ◽  
Vol 42 (04) ◽  
pp. 1207-1216 ◽  
Author(s):  
Berit Mørland
Keyword(s):  
Enzyme Activity ◽  
Platelet Aggregation ◽  
Peritoneal Macrophage ◽  
Cultured Cells ◽  
Culture Media ◽  
Human Platelets ◽  
Mouse Peritoneal Macrophage ◽  
Collagenase Activity ◽  
Partial Inhibition ◽  
Macrophage Phagocytosis

SummaryCollagen was incubated with cells or media fractions of mouse peritoneal macrophage cultures, and its aggregating effect on human platelets was tested. Incubation with lysates of cultured cells completely abolished the normal collagen-induced platelet aggregation, while incubation with media fractions only caused partial inhibition. The latter inhibition was more pronounced after macrophage phagocytosis of latex particles, while endocytosis of endotoxin had no effect.Corresponding macrophage cultures were also tested for specific collagenase activity, using 14C-glycine labelled collagen as substrate. Collagenase activity was found in the culture media fractions only, and the enzyme activity could be enhanced by endocytosis of latex as well as endotoxin.It appears that the effect of macrophage lysates and media on collagen-platelet interaction cannot be ascribed only to secretion of collagenase from macrophages.

scholarly journals Vagal Nerve Stimulation Blocks Peritoneal Macrophage Inflammatory Responsiveness After Severe Burn Injury

Shock ◽  
2012 ◽  
Vol 38 (3) ◽  
pp. 294-300 ◽  
Author(s):  
Nicole E. Lopez ◽  
Michael Krzyzaniak ◽  
Todd W. Costantini ◽  
Antonio De Maio ◽  
Andrew Baird ◽  
...  
Keyword(s):  
Peritoneal Macrophage ◽  
Nerve Stimulation ◽  
Burn Injury ◽  
Vagal Nerve ◽  
Vagal Nerve Stimulation ◽  
Severe Burn ◽  
Severe Burn Injury

Effects of spaceflight and PEG-IL-2 on rat physiological and immunological responses

1999 ◽  
Vol 86 (6) ◽  
pp. 2065-2076 ◽  
Author(s):  
Stephen K. Chapes ◽  
Steven J. Simske ◽  
Gerald Sonnenfeld ◽  
Edwin S. Miller ◽  
Robert J. Zimmerman
Keyword(s):  
Peritoneal Macrophage ◽  
Space Shuttle ◽  
Marrow Cell ◽  
Interleukin 2 ◽  
Plasma Corticosterone ◽  
Interferon Γ ◽  
Experimental Models ◽  
Sprague Dawley ◽  
Immunological Parameters ◽  
Immunological Responses

Sprague-Dawley rats were subjected to two 8-day spaceflights on the space shuttle. Rats housed in the National Aeronautics and Space Administration’s animal enclosure were injected (iv or sc) with pegylated interleukin-2 (PEG-IL-2) or a placebo. We tested the hypothesis that PEG-IL-2 would ameliorate some of the effects of spaceflight. We measured body and organ weights; blood cell differentials; plasma corticosterone; colony-forming units (macrophage and granulocyte macrophage); lymphocyte mitogenic, superantigenic, and interferon-γ responses; bone marrow cell and peritoneal macrophage cytokine secretion; and bone strength and mass. Few immunological parameters were affected by spaceflight. However, some spaceflight effects were observed in each flight. Specifically, peritoneal macrophage spontaneous secretion of tumor necrosis factor-α occurred in the first but not in the second flight. A significant monocytopenia and lymphocytopenia were detected in the second but not in the first flight. The second mission produced bone changes more consistent with past spaceflight investigations. PEG-IL-2 did not appear to be beneficial; however, this was mostly due to the lack of spaceflight effects. These studies reflect the difficulty in reproducing experimental models by using current space shuttle conditions.

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