scholarly journals Testicular Histopathology and Spermatogenesis in Mice with Scrotal Heat Stress

2021 ◽  
Author(s):  
Thuan Dang-Cong ◽  
Tung Nguyen-Thanh
Keyword(s):  
Heat Stress ◽  
Mouse Model ◽  
Reproductive System ◽  
Negative Impact ◽  
Testicular Tissue ◽  
Stress Exposure ◽  
Negative Effect ◽  
Human Reproductive ◽  
Testicular Histology ◽  
And Function

Chronic heat stress-induced testicular damage and function therefore adversely affect their reproduction. Some research shows that heat stress has a negative effect on histopathological features of testicular tissue structure and spermatogenesis. An animal model was used to evaluate the effect of heat stress on testicular histology changes and spermatogenesis. The mouse model of heat stress was established by submerged in a pre-warmed incubator. The testes’ tissue was fixed and stained with hematoxylin–eosin (H&E) for quantitative analysis of histopathological alterations and spermatogenesis according to Johnson scoring system. Mice exposed to heat stress exhibited degenerated and disorganized features of spermatogenic epithelium and reduced spermatogenic cells. Heat stress exposure shows a significantly reduced Johnson score compared to the control condition. The percentage of high Johnsen score points was decreased in heat-stress exposure mice, while the ratio of low Johnsen score points was gradually increased. This chapter describes a mouse model for studying the male reproductive system and applies the Johnsen scores system to assess testicular histopathology in the seminiferous tubule cross-section. Collectively, this chapter indicated a negative impact of heat stress on mouse spermatogenesis as well as the human reproductive system.

Human Adult Reproductive System

2017 ◽  
Author(s):  
Patrick Guthrie ◽  
Johanna Von Hofe ◽  
Rachael B Lancaster
Keyword(s):  
Reproductive System ◽  
Endocrine System ◽  
Reproductive Organs ◽  
Anatomy And Physiology ◽  
Human Reproductive ◽  
Reproductive Anatomy ◽  
Males And Females ◽  
And Function ◽  
Pituitary Adrenal Axis ◽  
Physiologic System

The human reproductive system is a unique combination of organs and endocrine components that is extremely complex and adaptive. The reproductive organs are distinct between males and females, and sexual differentiation is a result of genotype, gonadal type, and phenotype. The anatomic and physiologic system of each sex is composed with a set purpose: to propagate the human species. Linked closely to the reproductive system is the endocrine system, which provides the messengers and feedback mechanisms that allow the development, maintenance, and function of the reproductive organs. The gonads have both endocrine and exocrine functions, namely steroidogenesis and gametogenesis. This review focuses on the components of the endocrine system as well as male and female anatomy and physiology to fully grasp the human reproductive system.  Key words: fertility, hypothalamic-pituitary-adrenal axis, reproductive anatomy, sexual aging, sexual physiology

scholarly journals Effect of Bee Bread on Pregnancy Outcomes and Reproductive System of Rats under Heat Stress Exposure

2021 ◽  
Vol 17 (6) ◽  
pp. 781-793
Author(s):  
Nur Akmar Nadhirah Mohd Nor ◽  
Connie Fay Komilus ◽  
Mohd Nizam Haron ◽  
Fathurrahman Lananan ◽  
Ha Hou Chew ◽  
...  
Keyword(s):  
Heat Stress ◽  
Birth Weight ◽  
Birth Outcomes ◽  
Reproductive System ◽  
Pregnancy Outcomes ◽  
Extreme Temperature ◽  
High Energy ◽  
Human Consumption ◽  
Stress Exposure ◽  
Bee Bread

Exposure to extreme temperature during pregnancy was associated with abnormal birth outcomes including preterm birth, low birth weight, and placental abortion. Bee bread is a natural product created by bees that is highly nutritional and was recommended for human consumption as a source of high energy and protein. Hence, this study aims to determine the effect of bee bread on pregnancy outcomes and the reproductive system of the ovary and uterus in rats exposed to heat stress. 

Human Adult Reproductive System

2017 ◽  
Author(s):  
Patrick Guthrie ◽  
Johanna Von Hofe ◽  
Rachael B Lancaster
Keyword(s):  
Reproductive System ◽  
Endocrine System ◽  
Reproductive Organs ◽  
Anatomy And Physiology ◽  
Human Reproductive ◽  
Reproductive Anatomy ◽  
Males And Females ◽  
And Function ◽  
Pituitary Adrenal Axis ◽  
Physiologic System

The human reproductive system is a unique combination of organs and endocrine components that is extremely complex and adaptive. The reproductive organs are distinct between males and females, and sexual differentiation is a result of genotype, gonadal type, and phenotype. The anatomic and physiologic system of each sex is composed with a set purpose: to propagate the human species. Linked closely to the reproductive system is the endocrine system, which provides the messengers and feedback mechanisms that allow the development, maintenance, and function of the reproductive organs. The gonads have both endocrine and exocrine functions, namely steroidogenesis and gametogenesis. This review focuses on the components of the endocrine system as well as male and female anatomy and physiology to fully grasp the human reproductive system.  Key words: fertility, hypothalamic-pituitary-adrenal axis, reproductive anatomy, sexual aging, sexual physiology

scholarly journals IMPACT OF DIFFERENT GROUPS OF CONTRACEPTIVES ON THE FEMALE GENERAL CONDITION AND REPRODUCTIVE SYSTEM. ANALYTICAL REVIEW

2021 ◽  
Vol 67 (1) ◽  
pp. 7-7
Author(s):  
Ya.N. Pavlov ◽  
Keyword(s):  
Reproductive System ◽  
Negative Impact ◽  
Activity Level ◽  
Negative Consequences ◽  
Negative Effects ◽  
Pregnancy And Childbirth ◽  
Negative Effect ◽  
Analytical Review ◽  
Biological Methods ◽  
Effective Contraceptive

Considering the activity level of a modern woman and her desire for self-development and self-realization, she independently regulates and chooses the time that, in her opinion, is the most favorable for creating a family and having a child. Considering the fact that in most cases women use contraceptives to regulate pregnancy and childbirth, the issue of selecting the most effective contraceptive without negative consequences or health disturbances including reproductive system becomes extremely relevant. The purpose of this review is to identify contraceptives that, according to medical researchers and gynecologists, have minimum or no negative impact on women's health and yet help to prevent pregnancy. The analysis of WHO recommendations and conclusions made by both Russian and foreign researchers, including Yaglov V.V., Crosignani PG, H.K. Kallner, K. G. Danielsson and others during the past 10 years, has identified contraceptives with minimum negative effects and the highest possible effectiveness. Based on the conducted literature review, the following main groups of contraceptives have been identified and classified: hormonal (combined estrogen-gastrogenic drugs, mini-pills, injectable drugs, subcutaneous implants, hormonal, etc.) barrier (vaginal diaphragm, cervical cap, contraceptive sponge); biological methods (temperature method, cervical method, symptothermal method). The study showed that hormonal-type drugs turned out to have the highest effectiveness (99.9%) with negative consequences including hormonal disruptions, excess weight gain, and cancer development in rare cases. Regardless of the contraceptive type selected, the woman should first undergo a medical examination and consult a gynecologist who will tell which contraceptives are most appropriate in each case. Most researchers in the field of medicine and gynecology agree that the safest and most effective contraceptive method is male barrier contraceptives - condoms that do not have a negative effect on the female health, except for possible allergic reactions to lubricants used by the manufacturer.

Chaperonin as the normal controls and pathological anti-stress response in the human reproductive system

2016 ◽  
pp. 126-129
Author(s):  
M. Makarenko ◽  
◽  
D. Hovsyeyev ◽  
L. Sydoryk ◽  
◽  
...  
Keyword(s):  
Reproductive System ◽  
Stress Proteins ◽  
Physiological Stress ◽  
Protein Complexes ◽  
Reproductive Function ◽  
Intercellular Signaling ◽  
Toll Like Receptors ◽  
Wide Range ◽  
Protein Functions ◽  
And Function

Different kinds of physiological stress cause mass changes in the cells, including the changes in the structure and function of the protein complexes and in separate molecules. The protein functions is determined by its folding (the spatial conclusion), which depends on the functioning of proteins of thermal shock- molecular chaperons (HSPs) or depends on the stress proteins, that are high-conservative; specialized proteins that are responsible for the correct proteinaceous folding. The family of the molecular chaperones/ chaperonins/ Hsp60 has a special place due to the its unique properties of activating the signaling cascades through the system of Toll-like receptors; it also stimulates the cells to produce anti- inflammatory cytokines, defensins, molecules of cell adhesion and the molecules of MHC; it functions as the intercellular signaling molecule. The pathological role of Hsp60 is established in a wide range of illnesses, from diabetes to atherosclerosis, where Hsp60 takes part in the regulation of both apoptosis and the autoimmune processes. The presence of the HSPs was found in different tissues that are related to the reproductive system. Key words: molecular chaperons (HSPs), Toll-like receptors, reproductive function, natural auto antibody.

PD-L1 and survival in oral cavity squamous cell carcinoma

2020 ◽  
Vol 25 (4) ◽  
pp. 287-294
Author(s):  
S. I. Kutukova ◽  
N. P. Beliak ◽  
G. A. Raskin ◽  
M. S. Mukhina ◽  
Yu. V. Ivaskova ◽  
...  
Keyword(s):  
Squamous Cell Carcinoma ◽  
Oral Cavity ◽  
Cell Carcinoma ◽  
Tumor Cells ◽  
Squamous Cell ◽  
Immune Cells ◽  
Negative Impact ◽  
Progression Free Survival ◽  
Negative Effect ◽  
Effect Of Pd

Relevance. Prognostic value of PD-L1 expression in oral cavity squamous cell carcinoma (OCSCC) and its effect on survival is still controversial. It should be to determine the prognostic role of PD-L1 expression on tumor and immune cells of OCSCC and assess their effect on overall survival (OS) and progression-free survival (PFS).Materials and methods. A prospective study included 145 patients, first diagnosed with OCSCC. PD-L1 expression on tumor and immune cells, infiltrating tumor and its microenvironment, was assessed in all tumor samples by IHC, CPS was calculated. Cut-off values were determined by ROC analysis for identification of PD-L1 expression effect on OS and PFS.Results. Most patients with oral mucosa squamous cell carcinoma showed positive expression of PD-L1 on tumor (77.2%) and immune cells (92.4%). The median PD-L1 expression on tumor cells was 13.5% [1.0-40.0], the median PD-L1 expression on immune cells was 5.0% [1.0-11.0], and the median CPS – 18.0 [3.0-7.8]. Univariate and multivariate analyses revealed a significant negative effect of PD-L1 expression on immune cells ≤ 7% on OS (HR 0.66; 95% CI 0.45-0.93; p = 0.0498); PD-L1 expression in tumor cells ≤ 15% (HR 0.65; 95% CI 0.43-0.98; p = 0.0416) and CPS ≤ 21 (HR 0.62; 95% CI 0.44-0.92; p = 0.0183) for PFS. PD-L1 expression in tumor cells ≤ 6% (HR 0.71; 95% CI 0.47-1.08; p = 0.1096) and CPS ≤ 7 (RR 0.67; 95% CI 0.44-1.01; p = 0.0575) had a confident tendency to negative impact on OS.Conclusion. Positive PD-L1 expression in tumor and immune cells as well as CPS are effective additional factors in the prognosis of the disease course, OS and PFS in patients with OCSCC.

scholarly journals Inheritable testicular metabolic memory of high-fat diet causes transgenerational sperm defects in mice

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Luís Crisóstomo ◽  
Ivana Jarak ◽  
Luís P. Rato ◽  
João F. Raposo ◽  
Rachel L. Batterham ◽  
...  
Keyword(s):  
Sperm Quality ◽  
Feeding Habits ◽  
Reproductive Function ◽  
Principal Component ◽  
Testicular Tissue ◽  
Sperm Parameters ◽  
Metabolic Memory ◽  
High Fat ◽  
And Function ◽  
The Impact

AbstractThe consumption of energy-dense diets has contributed to an increase in the prevalence of obesity and its comorbidities worldwide. The adoption of unhealthy feeding habits often occurs at early age, prompting the early onset of metabolic disease with unknown consequences for reproductive function later in life. Recently, evidence has emerged regarding the intergenerational and transgenerational effects of high-fat diets (HFD) on sperm parameters and testicular metabolism. Hereby, we study the impact of high-fat feeding male mice (F0) on the testicular metabolome and function of their sons (F1) and grandsons (F2). Testicular content of metabolites related to insulin resistance, cell membrane remodeling, nutritional support and antioxidative stress (leucine, acetate, glycine, glutamine, inosine) were altered in sons and grandsons of mice fed with HFD, comparing to descendants of chow-fed mice. Sperm counts were lower in the grandsons of mice fed with HFD, even if transient. Sperm quality was correlated to testicular metabolite content in all generations. Principal Component Analysis of sperm parameters and testicular metabolites revealed an HFD-related phenotype, especially in the diet-challenged generation and their grandsons. Ancestral HFD, even if transient, causes transgenerational “inherited metabolic memory” in the testicular tissue, characterized by changes in testicular metabolome and function.

scholarly journals Relationships Among the Feeding Behaviors of a Mirid Bug on Cotton Leaves of Different Ages and Plant Biochemical Substances

2021 ◽  
Vol 21 (1) ◽  
Author(s):  
Haiyan Song ◽  
Zhaoke Dong ◽  
Lili Li ◽  
Zengbin Lu ◽  
Chao Li ◽  
...  
Keyword(s):  
Negative Impact ◽  
Leaf Age ◽  
Leaf Traits ◽  
Cotton Leaf ◽  
Young Plant ◽  
Feeding Behaviors ◽  
Probing Behavior ◽  
Negative Effect ◽  
Mirid Bug ◽  
The Relationship

Abstract Apolygus lucorum (Meyer-Dür) (Hemiptera: Miridae) tends to feed on young plant tissues. To explore the relationship between stylet probing behaviors of adult A. lucorum and conditions of cotton leaves, we conducted an experiment using electropenetrography (EPG). Behaviors were recorded on four cotton varieties, in relation to thickness and biochemical traits of differently-aged leaves. Cotton leaf age had a significant effect on the probing behavior of A. lucorum but cotton variety did not. One-day-old leaves of A. lucorum received the highest mean number of stylet probes (penetrations) per insect, and longest mean durations per insect of combined stylet probing or its components, cell rupture and ingestion behaviors. All of the leaf traits (thickness and biochemical substances) were similar among these four cotton varieties. Leaf thickness had a significantly negative effect on the same four variables above. Gossypol and tannin also had a negative impact on combined probing duration. Redundancy analysis showed that the four EPG variables were closely related to nutrient substances (amino acids, sugar, and water) while they had the opposite relationship with plant defense substances (gossypol and tannin). On cotton in the seedling stages, A. lucorum fed more readily on the youngest, thinnest leaves in our no-choice EPG experiments. Nutrients and chemical resistance substances determined the probing duration of A. lucorum. Our findings can contribute to better understanding of patterns of feeding and host consumption by A. lucorum, ultimately improving cotton resistance to A. lucorum.

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