scholarly journals Incorporation of Novel Elements in Bioactive Glass Compositions to Enhance Implant Performance

2021 ◽  
Author(s):  
Joy-anne N. Oliver ◽  
Olanrewaju Akande ◽  
Melanie Ecker
Keyword(s):  
Cell Proliferation ◽  
Bioactive Glass ◽  
Bacterial Infections ◽  
Glass Composition ◽  
Medical Applications ◽  
The Novel ◽  
Bioactive Glasses ◽  
Overall Performance ◽  
A Site ◽  
Glass Compositions

Increasing popularities of bioactive-glasses and their potential medical applications have led to countless studies into improving their material characteristics and overall performance. Some scientists hope to create new bioactive-glass compositions, while others seek to merely modify existing ones such as the novel 45S5 bioactive-glass composition; created by Dr. Larry Hench. These modifications aim to address potential complications that may arise at a site following implantation such as bacterial infections. In other cases, the incorporation of a selected element or compound may aim to improve the implant functioning by increasing cell proliferation. Although possibilities are plentiful, researchers avoid compromising the typical bioactive glass characteristics when doping with elements such as silver, or gold to achieve additional properties. This chapter elaborates on the incorporation of popular elements by doping bioactive-glass compositions to introduce desired properties based on the implant application.

scholarly journals A thermodynamic discourse on the dissolution behavior of bioactive glasses

2016 ◽  
Vol 2 (1) ◽  
Author(s):  
Barbara Pföss ◽  
Reinhard Conradt
Keyword(s):  
Bioactive Glass ◽  
Body Fluid ◽  
Solid Material ◽  
Aqueous System ◽  
Dissolution Behavior ◽  
Glassy Material ◽  
Bioactive Glasses ◽  
Gibbs Energies ◽  
The Impact ◽  
Glass Compositions

AbstractThe interaction between bioactive glass and body fluid is crucial for the special properties of this material, therefore a large number of experimental data is available in literature. However, a frame for systematic interpretation of these results in terms of understanding the mechanisms at the interface between glass and body medium and the relation between glass composition and dissolution behavior is still missing. For two multicomponent bioactive glasses, 45S5 and 13-93, the Gibbs energies of the glassy material on one side and their aqueous system on the other side were calculated individually. The difference between solid material and aqueous system further constitutes the pH dependent Gibbs energy of hydration, ∆Ghydr. The impact of glass compositions and glassy or crystalline state on ∆Ghydr is demonstrated referring to chemical durability. Along considerations regarding the aqueous system, the thermodynamic calculations proof the precipitation of hydroxyapatite inwater and simulated body fluid for a systemcontaining P2O5 and Ca2+. In the course of deriving the Gibbs energies for bioactive glass compositions via constitutional compounds, bioactive behavior is discussed from the point of coexisting equilibrium phases in the system of Na2O-CaO-SiO2.

scholarly journals The Evaluation of Formation and Bioactivity of New Sol-gel Bioactive Glass

2019 ◽  
Vol 35 (1) ◽  
Author(s):  
Bui Xuan Vuong
Keyword(s):  
Bioactive Glass ◽  
Sol Gel ◽  
Glass Ceramics ◽  
Medical Applications ◽  
Crystalline Solids ◽  
Bioactive Glasses ◽  
Central European Journal ◽  
Central European

In this paper, three ceramic compositions 50SiO2-50CaO (A), 45SiO2-45CaO-10P2O5 (B) and 40SiO2-40CaO-20P2O5 (C) (wt %) were synthesized by using the sol-gel technique. XRD analysis demonstrates that only sample C can form the glass material. Treated temperatures and heated times were also evaluated. Analysis data showed that the bioglass 40SiO2-40CaO-20P2O5 (wt %) can successfully elaborate when the ceramic powder heated at 750 oC for 3 hours. ‘‘In vitro’’ experiment was effectuated to investigate the bioactivity of bioglass 40SiO2-40CaO-20P2O5 by soaking powder samples in SBF solution. Obtained result confirmed the formation of hydroxyapatite (HA) phase on glass’s surface after 15 days of immersion, in which HA formation orients following (211) and (222) miller planes in crystalline structure of HA phase. Keywords Sol-gel; bioglass; hydroxyapatite; SBF; bioactivity References [1] D.F. Williams, Definitions in Biomaterials, Consensus Conference for the European Society for Biomaterials, Chester, UK, 1986.[2] L.L. Hench, Bioceramics: From Concept to Clinic, Journal of the American Ceramic Society, 74 (1991) 1487.[3] L.L. Hench, The story of Bioglass, Journal of Materials Science: Materials in Medicine, 17 (2006) 967.[4] X.V. Bui, H. Oudadesse, Y. Le Gal, A. Mostafa, P.Pellen and G. Cathelineau, Chemical Reactivity of Biocomposite Glass-Zoledronate, Journal of the Australian Ceramic Society, 46 (2010) 24.[5] L.L. Hench, Genetic design of bioactive glass, Journal of the European Ceramic Society, 29 (2009) 1257.[6] S. Kumar, P. Vinatier, A. Levasseur, K.J. Rao, Investigations of structure and transport in lithium and silver borophosphate glasses, Journal of Solid State Chemistry, 177 (2004)1723.[7] Z. Hong, A. Liu, L. Chen, X. Chen, X. Jing, Preparation of bioactive glass ceramic nanoparticles by combination of sol–gel and coprecipitation method, Journal of Non-Crystalline Solids, 355 (2009) 368.[8] D.B. Joroch, D.C. Clupper, Modulation of zinc release from bioactive sol–gel derived SiO2‐CaO‐ZnO glasses and ceramics, Journal of Biomedical Materials Research Part A, 82A (2007) 575.[9] J. Roman, S. Padilla, M. Vallet-Regi, Sol−Gel Glasses as Precursors of Bioactive Glass Ceramics, Chemistry of Materials, 15 (2003) 798.[10] J. Lao, J.M. Nedelec, Ph. Moretto, E. Jallot, Biological activity of a SiO2-CaO-P2O5 sol-gel glass highlighted by PIXE-RBS methods, Nuclear Instruments and Methods in Physics Research Section B, 245 (2006) 511.[11] [11] M. Vallet-Regi, L. Ruiz-Gonzalez, I. Izquierdo, J.M. Gonzalez-Calbet, Revisiting silica based ordered mesoporous materials: medical applications, Journal of Materials Chemistry, 16 (2006) 26.[12] W. Xia, J. Chang, Preparation and characterization of nano-bioactive-glasses (NBG) by a quick alkali-mediated sol–gel method, Materials Letters 61 (2007) 3251.[13] R. Li, A.E. Clark, L.L. Hench, An investigation of Bioactive Glass Powders by Sol-Gel Processing, Transactions of 16th Annual Meeting of the Societey for Biomaterials, 12 (1990) 40.[14] J. Lao, J.M. Nedelec, P. Moretto, E. Jallot, Imaging physicochemical reactions occurring at the pore surface in binary bioactive glass foams by micro ion beam analysis, Applied Materials and Interfaces, 6 (2010) 1737.[15] A. Balamurugan, G. Balossier, S. Kannan, J. Michel, A.H.S. Rebelo, J.M.F. Ferreira, Development and in vitro characterization of sol–gel derived CaO–P2O5–SiO2–ZnO bioglas, Acta Biomaterialia, 3 (2007) 255.[16] Z. Hong, A. Liu, L. Chen, X. Chen, X. Jing, Bioactive glass prepared by sol–gel emulsion, Journal of Non-Crystalline Solids, 355 (2009) 368.[17] O. Peital, E.D. Zanotto, L.L. Hench, Highly bioactive P2O5-Na2O-CaO-SiO2 glass-ceramics, Journal of Non-Crystalline Solids, 292 (2001) 115.[18] J. Liu, X. Miao, Sol-gel derived bioglass as a coating material for porous alumina scaffolds, Ceramics International, 30 (2004) 1781.[19] T. Kokubo, H. Takadama, How useful is SBF in predicting in vivo bone bioactivity. Biomaterials 27 (2006) 2907.[20] M. Dziadek, B. Zagrajczuk, P. Jelen, Z. Olejniczak, K.C. Kowalska, Structural variations of bioactive glasses obtained by different synthesis routes, Ceramics International, 42 (2016) 14700.[21] R. Lakshmi, V. Velmurugan and S. Sasikumar, Preparation and Phase Evolution of Wollastonite by Sol-Gel Combustion Method Using Sucrose as the Fuel, Combustion Science and Technology, 185 (2013) 1777.[22] G. Voicu, A. Bădănoiu, E. Andronescu1, C. M. Chifiruc, Synthesis, characterization and bioevaluation of partially stabilized cements for medical applications, Central European Journal of Chemistry, 11 (2013) 1657.[23] M.V. Regi, Ceramics for medical applications, Journal of the Chemical Society, Dalton Transactions, 2 (2001) 97.[24] G. Voicu, A.I. Bădănoiu, E. Andronescu, C.M. Chifiruc, Synthesis, characterization and bioevaluation of partially stabilized cements for medical applications, Central European Journal of Chemistry, 11 (2013) 1657.M. Wu, T. Wang, Y. Wang, F. Li, M. Zhou, X. Wu, A novel and facile route for synthesis of fine tricalcium silicate powders, Materials letters, 227 (2018), 187.

scholarly journals Near-field electrospinning of a polymer/bioactive glass composite to fabricate 3D biomimetic structures

2018 ◽  
Vol 5 (1) ◽  
Author(s):  
Krishna Kolan ◽  
Jie Li ◽  
Sonya Roberts ◽  
Julie A. Semon ◽  
Jonghyun Park ◽  
...  
Keyword(s):  
Cell Proliferation ◽  
Cell Viability ◽  
Bioactive Glass ◽  
Near Field ◽  
Three Dimensional ◽  
Biological Tissues ◽  
Glass Composite ◽  
3D Scaffold ◽  
Bioactive Glasses ◽  
3D Architecture

Bioactive glasses have recently gained attention in tissue engineering and three-dimensional (3D) bioprinting because of their ability to enhance angiogenesis. Some challenges for developing biological tissues with bioactive glasses include incorporation of glass particles and achieving a 3D architecture mimicking natural tissues. In this study, we investigate the fabrication of scaffolds with a polymer/bioactive glass composite using near-field electrospinning (NFES). An overall controlled 3D scaffold with pores, containing random fibers, is created and aimed to provide superior cell proliferation. Highly angiogenic borate bioactive glass (13-93B3) in 20 wt.% is added to polycaprolactone (PCL) to fabricate scaffolds using the NFES technique. Scaffolds measuring 5 mm × 5 mm × 0.2 mm3 in overall dimensions were seeded with human adipose-derived mesenchymal stem cells to investigate the cell viability. The cell viability on PCL and PCL+glass scaffolds fabricated using NFES technique and 3D printing is compared and discussed. The results indicated higher cell proliferation on 3D biomimetic scaffolds fabricated by NFES technique

scholarly journals Bioactive glasses and electrospun composites that release cobalt to stimulate the HIF pathway for wound healing applications

2021 ◽  
Vol 25 (1) ◽  
Author(s):  
Anu K. Solanki ◽  
Ferdinand V. Lali ◽  
Hélène Autefage ◽  
Shweta Agarwal ◽  
Amy Nommeots-Nomm ◽  
...  
Keyword(s):  
Wound Healing ◽  
Bioactive Glass ◽  
Hypoxia Inducible Factor ◽  
Magnesium Content ◽  
Ion Release ◽  
Bioactive Glasses ◽  
Covalent Bonds ◽  
Cobalt Ions ◽  
Hif Pathway ◽  
Glass Compositions

Abstract Background Bioactive glasses are traditionally associated with bonding to bone through a hydroxycarbonate apatite (HCA) surface layer but the release of active ions is more important for bone regeneration. They are now being used to deliver ions for soft tissue applications, particularly wound healing. Cobalt is known to simulate hypoxia and provoke angiogenesis. The aim here was to develop new bioactive glass compositions designed to be scaffold materials to locally deliver pro-angiogenic cobalt ions, at a controlled rate, without forming an HCA layer, for wound healing applications. Methods New melt-derived bioactive glass compositions were designed that had the same network connectivity (mean number of bridging covalent bonds between silica tetrahedra), and therefore similar biodegradation rate, as the original 45S5 Bioglass. The amount of magnesium and cobalt in the glass was varied, with the aim of reducing or removing calcium and phosphate from the compositions. Electrospun poly(ε-caprolactone)/bioactive glass composites were also produced. Glasses were tested for ion release in dissolution studies and their influence on Hypoxia-Inducible Factor 1-alpha (HIF-1α) and expression of Vascular Endothelial Growth Factor (VEGF) from fibroblast cells was investigated. Results Dissolution tests showed the silica rich layer differed depending on the amount of MgO in the glass, which influenced the delivery of cobalt. The electrospun composites delivered a more sustained ion release relative to glass particles alone. Exposing fibroblasts to conditioned media from these composites did not cause a detrimental effect on metabolic activity but glasses containing cobalt did stabilise HIF-1α and provoked a significantly higher expression of VEGF (not seen in Co-free controls). Conclusions The composite fibres containing new bioactive glass compositions delivered cobalt ions at a sustained rate, which could be mediated by the magnesium content of the glass. The dissolution products stabilised HIF-1α and provoked a significantly higher expression of VEGF, suggesting the composites activated the HIF pathway to stimulate angiogenesis.

CHARACTERIZATION OF SOME METHODS OF PREPARATION FOR BIOACTIVE GLASS COATING ON IMPLANTS

2006 ◽  
Vol 13 (01) ◽  
pp. 93-102 ◽  
Author(s):  
JIE MA ◽  
CHUANZHONG CHEN ◽  
LIANG YAO ◽  
QUANHE BAO
Keyword(s):  
Bioactive Glass ◽  
Drug Delivery Systems ◽  
Current Status ◽  
Medical Applications ◽  
Bone Cements ◽  
Glass Coating ◽  
Bioactive Glasses ◽  
Metallic Implants ◽  
Perfect Bonding

Since the discovery of Bioglass® by Hench, bioactive glasses have been used in many medical applications, such as drug delivery systems, nonload-bearing implants, and bone cements because of their excellent bioactivity and biocompatibility. However, due to their poor mechanical properties, these glasses cannot be used in load-bearing applications, where the metallic alloys are still main materials. One useful approach to solving the mechanical limitations of bioactive glasses is to apply the glasses as the coating on mechanically tough substrates; it was also recognized early that bioactive glasses could be used as coatings for prosthetic metallic implants. In this paper, the mechanism, characterization, and current status of some methods of preparation for bioactive glass coating on implants are introduced. In the end, to get the homogeneous and compact coating with perfect bonding strength, some ideas of improving the performance of coatings are also presented.

Ireland and Europe after 1973

2018 ◽  
Author(s):  
Derek Hand
Keyword(s):  
Seventeenth Century ◽  
The Novel ◽  
Real People ◽  
Economic Union ◽  
A Site

This chapter argues that the novel form is best suited to giving expression to the multifaceted Irish reality. Ireland, in the modern moment, is a place of incongruity and contradiction: it is at once a site of colonization and post-colonization, as well as simultaneously positioning itself as an integral part of a modern, globalized, economic union. The novel’s being bound to the immediate moment, while also aspiring toward the transcendence of immutable art, perfectly reflects an Irish mood caught between the violent actuality of war and a desire for mundane ordinariness. Indeed, it can be argued that the novel form offers a very human, and humane, lens through which to expose the hidden histories and anxieties of real people. Certainly the Irish novel has consistently done this from the seventeenth century onward, as it has charted the story of Ireland’s complex emergence into modernity.

scholarly journals Obsidian pyroclasts in the Yellowstone-Snake River Plain ignimbrites are dominantly juvenile in origin

2021 ◽  
Vol 83 (4) ◽  
Author(s):  
L. R. Monnereau ◽  
B. S. Ellis ◽  
D. Szymanowski ◽  
O. Bachmann ◽  
M. Guillong
Keyword(s):  
Glass Composition ◽  
Snake River Plain ◽  
Explosive Eruptions ◽  
Snake River ◽  
Pyroclastic Deposits ◽  
Volcanic Conduit ◽  
Trace Elemental ◽  
Multiple Cycles ◽  
River Plain ◽  
Glass Compositions

AbstractDense, glassy pyroclasts found in products of explosive eruptions are commonly employed to investigate volcanic conduit processes through measurement of their volatile inventories. This approach rests upon the tacit assumption that the obsidian clasts are juvenile, that is, genetically related to the erupting magma. Pyroclastic deposits within the Yellowstone-Snake River Plain province almost without exception contain dense, glassy clasts, previously interpreted as hyaloclastite, while other lithologies, including crystallised rhyolite, are extremely rare. We investigate the origin of these dense, glassy clasts from a coupled geochemical and textural perspective combining literature data and case studies from Cougar Point Tuff XIII, Wolverine Creek Tuff, and Mesa Falls Tuff spanning 10 My of silicic volcanism. These results indicate that the trace elemental compositions of the dense glasses mostly overlap with the vesiculated component of each deposit, while being distinct from nearby units, thus indicating that dense glasses are juvenile. Textural complexity of the dense clasts varies across our examples. Cougar Point Tuff XIII contains a remarkable diversity of clast appearances with the same glass composition including obsidian-within-obsidian clasts. Mesa Falls Tuff contains clasts with the same glass compositions but with stark variations in phenocryst content (0 to 45%). Cumulatively, our results support a model where most dense, glassy clasts reflect conduit material that passed through multiple cycles of fracturing and sintering with concurrent mixing of glass and various crystal components. This is in contrast to previous interpretations of these clasts as entrained hyaloclastite and relaxes the requirement for water-magma interaction within the eruptive centres of the Yellowstone-Snake River Plain province.

scholarly journals Epstein-Barr Virus Versus Novel Coronavirus-Induced Hemophagocytic Lymphohistocytosis: The Uncharted Waters

2020 ◽  
Vol 8 ◽  
pp. 232470962095010 ◽  
Author(s):  
Rawan Amir ◽  
Asim Kichloo ◽  
Jagmeet Singh ◽  
Ravinder Bhanot ◽  
Michael Aljadah ◽  
...  
Keyword(s):  
Bacterial Infections ◽  
Epstein Barr Virus ◽  
Genetic Mutations ◽  
High Grade ◽  
The Novel ◽  
Barr Virus ◽  
First Case ◽  
Epstein Barr ◽  
Virus Versus ◽  
Novel Coronavirus

Hemophagocytic lymphohistocytosis (HLH) is a hyperinflammatory syndrome characterized by fever, hepatosplenomegaly, and pancytopenia. It may be associated with genetic mutations or viral/bacterial infections, most commonly Epstein-Barr virus (EBV) and cytomegalovirus. As for the novel coronavirus, severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2), also known as COVID-19 (coronavirus disease-2019), the cytokine storm it triggers can theoretically lead to syndromes similar to HLH. In this article, we report a case of a 28-year-old female who presented with high-grade fevers, found to have both SARS-CoV-2 and EBV infections, and eventually began to show signs of early HLH. To our knowledge, this is the first case reported in literature that raises the possibility of SARS-CoV-2–related HLH development.

scholarly journals Enhanced apatite precipitation on a biopolymer-coated bioactive glass

2015 ◽  
Vol 1 (1) ◽  
Author(s):  
M. Araújo ◽  
M. Miola ◽  
A. Venturello ◽  
G. Baldi ◽  
J. Perez ◽  
...  
Keyword(s):  
Bioactive Glass ◽  
Body Fluid ◽  
Organic Coating ◽  
Medical Applications ◽  
Sintering Process ◽  
X Ray Diffraction ◽  
Ph Measurements ◽  
X Ray ◽  
Ft Ir ◽  
Scanning Electron

AbstractIn this work, sintered pellets of a silica-based bioactive glass were dip-coated with a biocompatible natural-derived polymer in order to investigate the influence of the organic coating on the glass bioactivity. After the sintering process optimization, uncoated and coated pellets have been characterized by means of scanning electron microscopy with energy dispersive spectroscopy (SEM, EDS), X-ray diffraction (XRD), Fourier transform infrared spectroscopy (FT-IR) and pH measurements, after the immersion in a simulated body fluid (SBF). An increased apatite forming ability and a better control of the pH during soaking of the samples in SBF were observed in the presence of the biopolymer. This result opens a new insight on the simple fabrication of highly bioactive hybrid inorganic-organic materials for medical applications.

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