scholarly journals Pharmacometabolomics: A New Horizon in Personalized Medicine

2021 ◽  
Author(s):  
Abdul-Hamid Emwas ◽  
Kacper Szczepski ◽  
Ryan T. McKay ◽  
Hiba Asfour ◽  
Chung-ke Chang ◽  
...  
Keyword(s):  
Health Status ◽  
Personalized Medicine ◽  
Treatment Efficacy ◽  
Analytical Methods ◽  
Health Assessment ◽  
Medical Professionals ◽  
Line Treatment ◽  
Drug Treatments ◽  
Personalized Diagnosis ◽  
First Line Treatment

Pharmacology is the predominant first-line treatment for most pathologies. However, various factors, such as genetics, gender, diet, and health status, significantly influence the efficacy of drugs in different patients, sometimes with fatal consequences. Personalized diagnosis substantially improves treatment efficacy but requires a more comprehensive process for health assessment. Pharmacometabolomics combines metabolomic, genomic, transcriptomic and proteomic approaches and therefore offers data that other analytical methods cannot provide. In this way, pharmacometabolomics more accurately guides medical professionals in predicting an individual’s response to selected drugs. In this chapter, we discuss the potentials and the advantages of metabolomics approaches for designing innovative and personalized drug treatments.

scholarly journals Stroke thrombectomy complication management

2021 ◽  
pp. neurintsurg-2021-017349
Author(s):  
Sara M Pilgram-Pastor ◽  
Eike I Piechowiak ◽  
Tomas Dobrocky ◽  
Johannes Kaesmacher ◽  
Juergen Den Hollander ◽  
...  
Keyword(s):  
Treatment Efficacy ◽  
Mechanical Thrombectomy ◽  
Complication Management ◽  
Line Treatment ◽  
Large Vessel Occlusion ◽  
First Line ◽  
Invasive Treatment ◽  
Vessel Occlusion ◽  
Endovascular Mechanical Thrombectomy ◽  
First Line Treatment

Endovascular mechanical thrombectomy (EVT) is widely accepted as the first-line treatment for acute ischemic stroke in patients with large vessel occlusion. Being an invasive treatment, this method is associated with various preoperative, perioperative, and postoperative complications. These complications may influence peri-interventional morbidity and mortality and therefore treatment efficacy and clinical outcome. The aim of this review is to discuss the most common types of complications associated with EVT, the probable mechanisms of injury, and effective methods to manage and prevent complications.

scholarly journals In VitroAntimicrobial Susceptibility Patterns of Blastocystis

2015 ◽  
Vol 59 (8) ◽  
pp. 4417-4423 ◽  
Author(s):  
Tamalee Roberts ◽  
Stephen Bush ◽  
John Ellis ◽  
John Harkness ◽  
Damien Stark
Keyword(s):  
Current Treatment ◽  
Line Treatment ◽  
First Line ◽  
Content Type ◽  
Treatment Regimens ◽  
Drug Treatments ◽  
Resistant Strains ◽  
Susceptibility Patterns ◽  
First Line Treatment

ABSTRACTBlastocystisis the most common human enteric protist with controversial clinical significance. Metronidazole is considered a first-line treatment forBlastocystisinfection; however, there has been increasing evidence for the lack of efficacy of this treatment. Treatment failure has been reported in several clinical cases, and recentin vitrostudies have suggested the occurrence of metronidazole-resistant strains. In this study, we tested 12Blastocystisisolates from 4 commonBlastocystissubtypes (ST1, ST3, ST4, and ST8) against 12 commonly used antimicrobials (metronidazole, paromomycin, ornidazole, albendazole, ivermectin, trimethoprim-sulfamethoxazole [TMP-SMX], furazolidone, nitazoxanide, secnidazole, fluconazole, nystatin, and itraconazole) at 10 different concentrationsin vitro. It was found that each subtype showed little sensitivity to the commonly used metronidazole, paromomycin, and triple therapy (furazolidone, nitazoxanide, and secnidazole). This study highlights the efficacy of other potential drug treatments, including trimethoprim-sulfamethoxazole and ivermectin, and suggests that current treatment regimens be revised.

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