Human Auditory System - Function and Disorders [Working Title]

Purpose The effects of neurological diseases on the auditory system have been a notable issue for investigators because the auditory pathway is closely associated with neural systems. The purposes of this study are to evaluate the efferent auditory system function and hearing quality in Parkinson's disease (PD) and to compare the findings with age-matched individuals without PD to present a perspective on aging. Method The study included 35 individuals with PD (mean age of 48.50 ± 8.00 years) and 35 normal-hearing peers (mean age of 49 ± 10 years). The following tests were administered for all participants: the first section of the Speech, Spatial and Qualities of Hearing Scale; pure-tone audiometry, speech audiometry, tympanometry, and acoustic reflexes; and distortion product otoacoustic emissions (DPOAEs) and contralateral suppression of DPOAEs. SPSS Version 25 was used for statistical analyses, and values of p < .05 were considered statistically significant. Results There were no statistically significant differences in the pure-tone audiometry thresholds and DPOAE responses between the individuals with PD and their normal-hearing peers ( p = .732). However, statistically significant differences were found between the groups in suppression levels of DPOAEs and hearing quality ( p < .05). In addition, a statistically significant and positive correlation was found between the amount of suppression at some frequencies and the Speech, Spatial and Qualities of Hearing Scale scores. Conclusions This study indicates that medial olivocochlear efferent system function and the hearing quality of individuals with PD were affected adversely due to the results of PD pathophysiology on the hearing system. For optimal intervention and follow-up, tasks related to hearing quality in daily life can also be added to therapies for PD.

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Derived Cochlear Nerve and Brainstem Evoked Responses of the Human Auditory System the Effect of Masking in the Derived Band

International Journal of Audiology ◽

10.3109/14992027809043135 ◽

1978 ◽

Vol 7 (2) ◽

pp. 73-80

Author(s):

D. J. Parker ◽

A. R. D. Thornton

Keyword(s):

Auditory System ◽

Cochlear Nerve ◽

Evoked Responses ◽

Human Auditory System

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Automated complex for recording and analyzing the evoked potentials of the human auditory system

Biomedical Engineering ◽

10.1007/bf00556570 ◽

1978 ◽

Vol 12 (2) ◽

pp. 77-79

Author(s):

I. V. Marchuk ◽

A. N. Tsisarenko ◽

�. A. Bakai

Keyword(s):

Evoked Potentials ◽

Auditory System ◽

Human Auditory System

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An analogue VLSI model of periodicity extraction in the human auditory system

ICONIP'99. ANZIIS'99 & ANNES'99 & ACNN'99. 6th International Conference on Neural Information Processing. Proceedings (Cat. No.99EX378) ◽

10.1109/iconip.1999.843970 ◽

2003 ◽

Cited By ~ 5

Author(s):

A. van Schaik

Keyword(s):

Auditory System ◽

Human Auditory System ◽

Analogue Vlsi

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Deafness-in-a-dish: modeling hereditary deafness with inner ear organoids

Human Genetics ◽

10.1007/s00439-021-02325-9 ◽

2021 ◽

Author(s):

Daniel R. Romano ◽

Eri Hashino ◽

Rick F. Nelson

Keyword(s):

Animal Models ◽

Inner Ear ◽

Auditory System ◽

Hearing Aids ◽

Molecular Mechanisms ◽

Functional Disability ◽

Experimental Studies ◽

Hereditary Deafness ◽

Human Auditory System ◽

Human Inner Ear

AbstractSensorineural hearing loss (SNHL) is a major cause of functional disability in both the developed and developing world. While hearing aids and cochlear implants provide significant benefit to many with SNHL, neither targets the cellular and molecular dysfunction that ultimately underlies SNHL. The successful development of more targeted approaches, such as growth factor, stem cell, and gene therapies, will require a yet deeper understanding of the underlying molecular mechanisms of human hearing and deafness. Unfortunately, the human inner ear cannot be biopsied without causing significant, irreversible damage to the hearing or balance organ. Thus, much of our current understanding of the cellular and molecular biology of human deafness, and of the human auditory system more broadly, has been inferred from observational and experimental studies in animal models, each of which has its own advantages and limitations. In 2013, researchers described a protocol for the generation of inner ear organoids from pluripotent stem cells (PSCs), which could serve as scalable, high-fidelity alternatives to animal models. Here, we discuss the advantages and limitations of conventional models of the human auditory system, describe the generation and characteristics of PSC-derived inner ear organoids, and discuss several strategies and recent attempts to model hereditary deafness in vitro. Finally, we suggest and discuss several focus areas for the further, intensive characterization of inner ear organoids and discuss the translational applications of these novel models of the human inner ear.

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