scholarly journals Chronic Venous Ulcer

2021 ◽  
Author(s):  
Walid A.M. Ganod
Keyword(s):  
Quality Of Life ◽  
Platelet Rich Plasma ◽  
Venous Ulcer ◽  
Wound Management ◽  
Research Review ◽  
Leg Ulcers ◽  
Limb Edema ◽  
Therapeutic Procedures ◽  
Platelet Concentration

This research review is endeavoring to shed the light on the cause and effect of Chronic Venous Ulcer (CVU) in line with its therapeutic procedures. In the last two decades, a lot of the changes occurred in strategy of wound management through developing adjunctive therapy that supported wound healing. Eventually, the latest development was in platelet concentration technology produced the platelet-rich fibrin (PRF). It was categorized as the 2nd generation of platelet concentration family after Platelet Rich Plasma (PRP). Considering that Venous Leg Ulcers (VLUs) accounted for 70% of all leg ulcers and estimated one percent of the population where age as an essential factor has increased its prevalence. The chronicity and refractory nature of venous ulcer had a great effect on the quality of life and work productivity of patients apart from, the expenditure of significant amount of medical resources and efforts. Therefore, the ultimate goal of (VLU) management was to induce a rapid healing without recurrence which mainly helped to improve the quality of life (QoL). The first therapeutic procedure used in treatment of VLU was compression therapy where the application of effective graduated compression decreased the overload in venous system and venous reflux. Furthermore, it accelerated the capillary of blood flow and decreased the capillary of fluid leakage which in return alleviated the limb edema.

scholarly journals Does intra articular platelet rich plasma injection improve function, pain and quality of life in patients with osteoarthritis of the knee? A randomized clinical trial

2014 ◽  
Vol 6 (3) ◽  
Author(s):  
Seyed Mansoor Rayegani ◽  
Seyed Ahmad Raeissadat ◽  
Morteza Sanei Taheri ◽  
Marzieh Babaee ◽  
Mohammad Hassan Bahrami ◽  
...  
Keyword(s):  
Quality Of Life ◽  
Clinical Trial ◽  
Randomized Clinical Trial ◽  
Platelet Rich Plasma ◽  
Short Form ◽  
Control Group ◽  
Osteoarthritis Of The Knee ◽  
Therapeutic Exercise ◽  
Platelet Concentration

We designed a randomized clinical trial with control group, to investigate the effects of platelet rich plasma (PRP) on pain, stiffness, function and quality of life in patients with knee osteoarthritis. Patients were randomly divided in two groups. For both groups of participants, therapeutic exercise was prescribed. In the PRP group, two courses of leukocyte rich PRP (5.6 fold higher platelet concentration) with a 4-week interval was injected. For each participant, Western Ontario and McMaster University’s Arthritis Index (WOMAC) and the SF-36 questionnaire (Farsi version) were filled at the baseline and 6 months after treatments. Thirty-one patients in the PRP group and 31 patients in the control group were studied. Mean changes of total WOMAC, physical component summery and mental component summery of Short Form-36 in PRP group showed better improvement than control group (P<0.05). This study showed that intra articular PRP knee injection combined with therapeutic exercise can be more effective in pain reduction and improvement of stiffness and quality of life, compared with therapeutic exercise alone.

Evaluating the efficacy of intra-articular injections of platelet rich plasma (PRP) in rheumatoid arthritis patients and its impact on inflammatory cytokines, disease activity and quality of life.

2020 ◽  
Vol 16 ◽  
Author(s):  
Dalia S. Saif ◽  
Nagwa N. Hegazy ◽  
Enas S. Zahran
Keyword(s):  
Quality Of Life ◽  
Rheumatoid Arthritis ◽  
Disease Activity ◽  
Inflammatory Cytokines ◽  
Platelet Rich Plasma ◽  
Joint Inflammation ◽  
Monthly Interval ◽  
Post Injection ◽  
Tnf Α

Background: Among rheumatoid arthritis patients (RA), general disease activity is well regulated by diseasemodifying anti-rheumatic medications (DMARDS), but sometimes local inflammation still persists among a few joints. Adjuvant modern molecular interventions as Platelet Rich Plasma (PRP) with a suggested down regulating effect on inflammatory mediators has a proven effect in management of RA. We aim to evaluate the therapeutic effect of intra-articular PRP versus steroid in RA patients and their impact on inflammatory cytokines IL1B , TNF α, local joint inflammation, disease activity and quality of life (QL). Methods: Open labeled parallel randomized control clinical trial was carried out on 60 RA patients randomly divided into 2 groups, Group 1: included 30 patients received 3 intra-articular injections of PRP at monthly interval, Group 2: included 30 patients received single intra-articular injection of steroid. They were subjected to clinical, laboratory, serum IL1B and TNF α assessment at baseline and at 3, 6 months post injection. Results: Patients of both groups showed improvements in their scores of evaluating tools at 3months post injection and this improvement was persistent in the PRP group up to 6 months post injection while it was continued only for 3 months in the steroid group. Conclusions: PRP is a safe, effective and useful therapy in treating RA patients who had insufficient response and persistent pain and inflammation in just one or two joints through its down regulating effect on inflammatory cytokines IL1B, TNF α with subsequent improvement of local joint inflammation, disease activity and QL.

Updated leg ulcer pathway: improving healing times and reducing costs

2019 ◽  
Vol 28 (20) ◽  
pp. S21-S26
Author(s):  
Leanne Atkin ◽  
Alison Schofield ◽  
Anita Kilroy-Findley
Keyword(s):  
Quality Of Life ◽  
Leg Ulcer ◽  
Leg Ulcers ◽  
Nursing Time ◽  
Venous Leg Ulcers ◽  
Reduced Costs ◽  
Reducing Costs

Regardless of the amount of literature and evidence on leg ulcer management, there are still significant variations in treatment. Implementing a standardised leg ulcer pathway to ensure patients are appropriately and timely assessed could help reduce nursing time and overall costs, while improving healing outcomes and patients' quality of life. Such a pathway was introduced in Lincolnshire and Leicestershire, UK, to treat venous leg ulcers (VLUs). The results showed improved healing times, reduced costs and fewer nurse visits, among other findings.

Superabsorbent Wound Dressing for Management of Patients With Moderate-to-Highly Exuding Chronic Leg Ulcers: An Early Stage Model-Based Benefit–Harm Assessment

2021 ◽  
pp. 153473462110093
Author(s):  
Vladica M. Velickovic ◽  
Jean P. Lembelembe ◽  
Francisco Cegri ◽  
Ivana Binic ◽  
Amr B. Abdelaziz ◽  
...  
Keyword(s):  
Quality Of Life ◽  
Early Stage ◽  
Absolute Risk ◽  
Standard Of Care ◽  
Risk Difference ◽  
Wound Dressings ◽  
Leg Ulcers ◽  
Related Quality ◽  
Health Related

The aim of the research is to assess the benefit–harm of superabsorbent polymers wound dressings based on polyacrylate polymers (SAPs) compared with standard of care (SoC) dressing mix for patients with moderate-to-highly exuding hard-to-heal leg ulcers. The SoC dressings mix was composed of other superabsorbents in 29% of cases, antimicrobials 26%, foams 20%, alginates 5%, and other dressings 19% weighted according to their frequency. We have used the decision-analytic modeling method, Markov process, as an adequate analytical solution for medical prognosis. We have combined the systematic literature search to identify the most relevant inputs for the analysis, with available patient-level clinical data concerning benefits of superabsorbent to generate a robust prediction of patient-relevant outcomes, including healing rates and health-related quality of life. Besides, we have qualitatively described adverse events associated with those treatments. Our research indicates that SAPs when compared with SoC dressing mix in a patient with moderate-to-highly excluding leg ulcers are leading to an improved healing rate with an absolute risk difference of 2.20% in 6 months and a relative risk of 1.07 in favor of SAP dressings. The attributable fraction among those exposed to SAP dressings of 6.6%, meaning that 6.6% of the healed ulcers could be attributed to having had the SAP dressing treatment instead of the SoC dressing treatment. Besides, SAP dressings lead to improved quality of life measured as incremental quality-adjusted life weeks (QALWs) of 0.13 QALWs.

scholarly journals Aspects Related to Venous Ulcer Healing and its Influence on Quality of Life

10.5772/64913 ◽  
2016 ◽  
Author(s):  
Gilson V. Torres ◽  
Aline M. Pergola-Marconato ◽  
Thalyta C. Mansano-Schlosser ◽  
Rhayssa O. Araújo ◽  
Dalva C. Silva ◽  
...  
Keyword(s):  
Quality Of Life ◽  
Ulcer Healing ◽  
Venous Ulcer

Health-Related Quality of Life in Patients with Venous Ulceration

2001 ◽  
Vol 16 (1) ◽  
pp. 12-16 ◽  
Author(s):  
A. Howard ◽  
A. H. Davies
Keyword(s):  
Quality Of Life ◽  
Outcome Measures ◽  
Outcome Measurement ◽  
Venous Ulcer ◽  
Health Related Quality ◽  
Venous Ulceration ◽  
Complete Treatment ◽  
Related Quality ◽  
Health Related

Aim: To review the role of Health Related Quality of Life (HRQL) assessments in the management of patients with venous ulceration. Method: A search of electronic databases and reference lists delivered numerous articles containing a variety of HRQL assessments for venous ulcer treatment. Synthesis: The salient points from the literature were collaborated in order to establish which outcome measures best reflect the quality of care delivered. The treatment of chronic venous leg ulceration is often prolonged and a permanent cure is frequently unattainable. An improvement in a patient's condition needs to be demonstrated in order to determine the benefit of a surgical treatment. The assessment of HRQL is increasingly recognised as a valuable surgical outcome measurement. Conclusion: The combination of ‘standard’ clinical outcome measures, the generic SF-36 and a specific ‘venous ulcer’ HRQL questionnaire can produce a more complete treatment outcome assessment in patients with venous ulceration.

scholarly journals Quality of life for venous ulcer patients: a comparative study in Brazil/Portugal

2013 ◽  
Vol 12 (3) ◽  
Author(s):  
Thalyne Yuri Araújo Farias Dias ◽  
Isabelle Katherinne Fernandes Costa ◽  
Samilly Márjore Dantas Liberato ◽  
Amanda Jéssica Gomes de Souza ◽  
Felismina Rosa Parreira Mendes ◽  
...  
Keyword(s):  
Quality Of Life ◽  
Comparative Study ◽  
Venous Ulcer

scholarly journals A Mobile App for Thyroid Cancer Patients Aiming to Enhance Their Quality of Life: Protocol for a Quasiexperimental Interventional Pilot Study

10.2196/13409 ◽  
2020 ◽  
Vol 9 (3) ◽  
pp. e13409 ◽  
Author(s):  
Evanthia Giannoula ◽  
Ioannis Iakovou ◽  
Ioannis Katsikavelas ◽  
Panagiotis Antoniou ◽  
Vasilios Raftopoulos ◽  
...  
Keyword(s):  
Quality Of Life ◽  
Thyroid Cancer ◽  
Intervention Group ◽  
Well Being ◽  
Good Prognosis ◽  
Mobile App ◽  
Information Platform ◽  
Therapeutic Procedures ◽  
Eortc Qlq

Background Thyroid cancer (TC) is one of the fastest growing cancers all over the world. Differentiated thyroid cancer (DTC) is the most frequent subtype of TC. When appropriate treatment is given, the prognosis for the patient is generally excellent. Despite the generally good prognosis of thyroid carcinomas, the symptoms may range from emotional to physical discomfort, depending on the thyroid hormone status, which can severely affect the patient. Moreover, the diagnostic and therapeutic procedures that DTC patients have to undergo, such as thyroidectomy and radioiodine therapy, significantly affect their mental and physical well-being. Often, the physician only addresses the favorable prognosis of DTC compared with other cancer types and neglects to assess issues related to the quality of life (QoL) of the patient; this was the reason we decided to design a mobile app for DTC patients and their caregivers. Objective The aim of this study is to research the feasibility and applicability of an mHealth app tailored to DTC patients, as reflected in their QoL. The main features of the developed app offer access to useful information about thyroid cancer, diagnostic tests, and the appropriate therapy administered to DTC patients. Methods Based on the existing literature, we created an up-to-date information platform regarding TC and especially DTC. In order to develop an effective app that can be implemented in current health care, we designed a section where the patient and physician can keep a medical record in an effort to enable access to such information at any time. Finally, we designed a user-friendly notification program, including pill prescription, follow-up tests, and doctor visit reminders in order to equally facilitate the lives of the patient and physician. Results Having developed this mobile app, we aim to conduct a pilot quasiexperimental interventional trial. Our intention is to enroll at least 30 TC patients and assign them to intervention or control groups. Both groups will receive standard care for treating and monitoring TC, and the intervention group will also receive and use the DTC app. TC patients’ QoL will be assessed for both control and intervention groups in order to examine the effectiveness of the DTC app. QoL will be assessed through the QoL core questionnaire European Organisation for Research and Treatment of Cancer (EORTC) QLQ-THY34 in combination with the EORTC QLQ-C30 questionnaire through quantitative statistical analysis. Conclusions The use of mHealth apps can play a significant role in patient education, disease self-management, remote monitoring of patients, and QoL improvement. However, the main limitation of the majority of existing studies has been the lack of assessing their usefulness as well as the absence of specific instruments to carry out this assessment. In light of those considerations, we developed a mobile app tailored to the needs of DTC patients. Furthermore, we evaluated its contribution to the QoL of the patients by using the EORTC QLQ-THY34 questionnaire, an accurate and safe instrument for the evaluation of the QoL in TC patients, while supporting future planned endeavors in the field. International Registered Report Identifier (IRRID) PRR1-10.2196/13409

Recurrent venous leg ulcers: management in general practice

2021 ◽  
Vol 32 (6) ◽  
pp. 220-225
Author(s):  
Annemarie Brown
Keyword(s):  
Quality Of Life ◽  
General Practice ◽  
Financial Burden ◽  
Self Care ◽  
Leg Ulcers ◽  
Recurrence Rates ◽  
Practice Nurses ◽  
Venous Leg Ulcers ◽  
Primary Prevention Strategy

Venous leg ulcers commonly recur. Annemarie Brown highlights some self-care strategies that patients can use to reduce their risk Chronic venous leg ulcers are commonly seen in general practice and although healing rates for leg ulcers have improved, recurrence rates are high with around 60–70% reported to recur after healing. The primary prevention strategy is the life-long wearing of compression hosiery; however, compliance is low for several reasons including lack of understanding of the need to wear compression hosiery and difficulties applying and removing it. Self-care strategies such as physical exercise and mobility, leg elevation and appropriate skin care, can help to prevent recurrence of venous leg ulcers. Practice nurses are ideally placed to provide this advice, which can help improve patient's quality of life while reducing the financial burden of treating open ulceration for the NHS.

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