scholarly journals The Complex Relationship of Periodontal Disease and Rheumatoid Arthritis

2021 ◽  
Author(s):  
Maria-Alexandra Martu ◽  
Elena Rezus ◽  
Diana Tatarciuc ◽  
Ionut Luchian ◽  
Irina-Georgeta Sufaru ◽  
...  
Keyword(s):  
Rheumatoid Arthritis ◽  
Risk Factors ◽  
Periodontal Disease ◽  
Bone Destruction ◽  
Lifestyle Changes ◽  
Common Denominator ◽  
Inflammatory Reactions ◽  
Multifactorial Diseases ◽  
Reactive Protein ◽  
Relationship Of

The relationship between periodontitis and systemic diseases is an important part of clinical periodontal research, which has been growing steadily. Even though the etiologies of periodontal disease and rheumatoid arthritis (RA) differ, these pathologies have many common features, both being multifactorial diseases characterized by localized chronic inflammatory reactions, which are fuelled by an analogous set of cytokines (among many, the most prominent being Tumour Necrosis Factor (TNF), Interleukin (IL) 6 and 17), leading to high systemic circulating concentrations of inflammatory markers such as C-reactive protein (CRP). It was not until the discovery of peptidylarginine deiminase (PAD) mediated citrullination of proteins by Porphyromonas gingivalis that the link between the two diseases was purely speculative. This citrullination initiates a series of events which culminate in the production of anti-citrullinated protein antibodies (ACPA) and, finally, in the clinical manifestation of rheumatoid arthritis. Another common denominator is the bone destruction caused by proinflammatory cytokines secreted by T 17 helper cells (TH17) which is the pathological hallmark of both diseases. Other notable common areas are shared risk factors such as environmental and genetic risk factors. Regarding treatment, neither pathologies have a definitive cure, however, several strategies are employed, some of which are common, such as diet and lifestyle changes, and immunomodulating medication applied locally or systemically.

scholarly journals THE RISK OF FALLS IN PATIENTS WITH RHEUMATOID ARTHRITIS

2017 ◽  
Vol 54 (6) ◽  
pp. 705-711 ◽  
Author(s):  
N. V. Toroptsova ◽  
A. Yu. Feklistov
Keyword(s):  
Rheumatoid Arthritis ◽  
Risk Factors ◽  
Risk Factor ◽  
Independent Risk Factor ◽  
Risk Of Falls ◽  
Relationship Of ◽  
The Relationship

The paper discusses the materials of investigations dealing with falls as an independent risk factor for fractures in patients with rheumatoid arthritis (RA). It gives data on the incidence and possible risk factors of falls in this category of patients. According to the data obtained, the prevalence of falls in different countries varies from 10 to 50%, which may be related to differences in the methods of collecting information, and the relationship of the investigated factors with the risk of falls in patients with RA is uniquely unproven and calls for further investigations.

scholarly journals Bone Loss, Osteoporosis, and Fractures in Patients with Rheumatoid Arthritis: A Review

2020 ◽  
Vol 9 (10) ◽  
pp. 3361
Author(s):  
Patrice Fardellone ◽  
Emad Salawati ◽  
Laure Le Monnier ◽  
Vincent Goëb
Keyword(s):  
Rheumatoid Arthritis ◽  
Risk Factors ◽  
Bone Loss ◽  
Interleukin 1 ◽  
Bone Destruction ◽  
Fragility Fractures ◽  
Systemic Effect ◽  
Vertebral Fracture Assessment ◽  
Mineral Density ◽  
Accurate Treatment

Rheumatoid arthritis (RA) is often characterized by bone loss and fragility fractures and is a frequent comorbidity. Compared with a matched population, RA patients with fractures have more common risk factors of osteoporosis and fragility fractures but also risk factors resulting from the disease itself such as duration, intensity of the inflammation and disability, and cachexia. The inflammatory reaction in the synovium results in the production of numerous cytokines (interleukin-1, interleukin-6, tumor necrosis factor) that activate osteoclasts and mediate cartilage and bone destruction of the joints, but also have a systemic effect leading to generalized bone loss. Regular bone mineral density (BMD) measurement, fracture risk assessment using tools such as the FRAX algorithm, and vertebral fracture assessment (VFA) should be performed for early detection of osteoporosis and accurate treatment in RA patients.

scholarly journals Are There Any Common Genetic Risk Markers for Rheumatoid Arthritis and Periodontal Diseases? A Case-Control Study

2019 ◽  
Vol 2019 ◽  
pp. 1-11 ◽  
Author(s):  
Susanne Schulz ◽  
Natalie Pütz ◽  
Elisa Jurianz ◽  
Hans-Günter Schaller ◽  
Stefan Reichert
Keyword(s):  
Rheumatoid Arthritis ◽  
Risk Factors ◽  
Periodontal Disease ◽  
Case Control Study ◽  
Multivariate Analyses ◽  
Periodontal Diseases ◽  
Case Control ◽  
Genetic Variations ◽  
The Impact ◽  
Control Study

Background. Several studies suggest that there is a biologically plausible connection between rheumatoid arthritis (RA) and periodontal diseases (PD). Both disorders are characterized as multifactorial diseases potentially sharing common risk factors. Based on the inflammatory nature of RA and PD, the impact of genetic variations of genes of the immune system on both diseases was studied in this study.Materials and Methods. We conducted a case-control study (n=201) comparing 101 RA patients suffering from periodontal disease of different severities (no/mild PD vs. severe PD) with 100 systemically healthy controls without RA and severe PD. The genotype, allele, and haplotype distributions of 22 SNPs of 13 pro- and anti-inflammatory cytokines were assessed applying sequence-specific PCR.Results. Evaluating the impact of cytokine SNPs in RA, we identified the G allele of rs1801275 in IL4Rα(p=0.043) and the G allele of rs361525 in TNFα(p=0.005) as disease-associated risk factors in bivariate analyses. In multivariate analyses, these significant associations could not be proven. The A allele of rs2430561 in IFNγwas indicative for severe periodontitis among the patients with rheumatoid arthritis (p=0.039). Investigating the impact of rs2430561 in IFNγon comorbidity using binary logistic regression analyses, the A allele was confirmed as an independent risk factor for severe periodontal disease and RA (p=0.024).Conclusions. These results emphasize the association of genetic variations in proinflammatory cytokines (TNFαand IFNγ) and cytokine receptor (IL4Rα) and RA and periodontal diseases. In multivariate analyses, the A allele of IFNγwas proven to be a significant marker of RA and PD comorbidities. The study broadens the knowledge about disease-specific differences in genetic composition and provides an improved understanding of a possible association of both diseases.

The relationship of hepatotoxic risk factors and liver histology in methotrexate therapy for juvenile rheumatoid arthritis

1999 ◽  
Vol 134 (1) ◽  
pp. 47-52 ◽  
Author(s):  
Philip J. Hashkes ◽  
William F. Balistreri ◽  
Kevin E. Bove ◽  
Edgar T. Ballard ◽  
Murray H. Passo
Keyword(s):  
Rheumatoid Arthritis ◽  
Risk Factors ◽  
Juvenile Rheumatoid Arthritis ◽  
Methotrexate Therapy ◽  
Liver Histology ◽  
Relationship Of ◽  
The Relationship
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