scholarly journals Löfgren’s Syndrome

2021 ◽  
Author(s):  
Shiyu Wang ◽  
Shailendra Singh
Keyword(s):  
Erythema Nodosum ◽  
Rare Presentation ◽  
Prompt Treatment ◽  
Hilar Adenopathy ◽  
Löfgren’S Syndrome ◽  
Acute Polyarthritis ◽  
Oral Glucocorticoids ◽  
Symptomatic Control

Löfgren’s syndrome presents as acute sarcoid arthritis, with a triad of hilar adenopathy, acute polyarthritis and erythema nodosum. Löfgren’s syndrome is self-limited, erythema nodosum, hilar adenopathy and acute polyarthritis usually resolve within a few weeks to months, however polyarthritis can last for up to 2 years. Treatment involves symptomatic control with NSAIDs/colchicine or oral glucocorticoids until symptoms resolve, if disease is resistant to these therapies, hydroxychloroquine, methotrexate or infliximab can be used. Löfgren’s syndrome is a rare presentation of sarcoidosis occurring in only about 5–10% of sarcoid patients. It is, however, important to recognize as it is the most common form of acute sarcoid arthritis and prompt treatment can prevent unnecessary prolonged discomfort for patients.

scholarly journals Reactivation of Old Scars in an Elderly Man Revealing Löfgren's Syndrome

2013 ◽  
Vol 2013 ◽  
pp. 1-3
Author(s):  
Vishnu Vardhan Reddy Munagala ◽  
Vaishali Tomar ◽  
Amita Aggarwal
Keyword(s):  
Rare Case ◽  
Erythema Nodosum ◽  
Febrile Illness ◽  
High Resolution Computed Tomography ◽  
Short Course ◽  
Oral Steroids ◽  
Hilar Adenopathy ◽  
Löfgren’S Syndrome ◽  
Systemic Symptoms ◽  
Noncaseating Granulomas

Here, we report the case of a 55-year-old man with reactivation of old cutaneous scars associated with a febrile illness, episcleritis, polyarthralgias, erythema nodosum and hilar adenopathy. High-resolution computed tomography (HRCT) revealed right paratracheal, bilateral hilar, and subcarinal lymphadenopathy without any nodular densities in both lung fields. A scar biopsy revealed multiple noncaseating granulomas and confirmed the diagnosis of sarcoidosis. A short course of oral steroids led to regression of systemic symptoms, and the scars returned to baseline size. This patient represented a rare case of simultaneous Löfgren’s syndrome and scar sarcoidosis.

scholarly journals Acute and Chronic Sarcoid Arthropathies: Characteristics and Treatments From a Retrospective Nationwide French Study

2020 ◽  
Vol 7 ◽  
Author(s):  
Carlotta Cacciatore ◽  
Pierre Belnou ◽  
Sara Thietart ◽  
Carole Desthieux ◽  
Mathilde Versini ◽  
...  
Keyword(s):  
Erythema Nodosum ◽  
Skin Lesions ◽  
Tnf Inhibitors ◽  
Joint Involvement ◽  
Clinical Phenotypes ◽  
Treatment Regimens ◽  
French Study ◽  
Histological Criteria ◽  
Multicenter Analysis ◽  
Löfgren’S Syndrome

Introduction: We aimed to analyze patients with acute and chronic joint involvements in sarcoidosis.Methods: This is a retrospective multicenter analysis of patients with proven sarcoidosis, as defined by clinical, radiological, and histological criteria, with at least one clinical and/or ultrasonographic synovitis.Results: Thirty-nine patients with sarcoid arthropathy were included, and among them 19 had acute sarcoidosis (Lofgren's syndrome). Joint involvement and DAS44-CRP were not significantly different in acute and chronic sarcoid arthropathies. Acute forms were more frequent than chronic sarcoid arthropathy in Caucasians, without any difference of sex or age between these 2 forms. Joint involvement was frequently more symmetrical in acute than chronic forms (100 vs. 70%; p < 0.05), with a more frequent involvement in wrists and ankles in acute forms, whereas the tender and swollen joint counts and the DAS44-CRP were similar between the 2 groups. Skin lesions were significantly more frequent in patients with acute forms [17 (89%) vs. 5 (25%); p < 0.05] and were erythema nodosum in all patients with Löfgren's syndrome and sarcoid skin lesions in those with chronic sarcoidosis. Among 20 patients with chronic sarcoidosis, treatment was used in 17 (85%) cases, and consisted in NSAIDs alone (n = 5; 25%), steroids alone (n = 5; 25%), hydroxychloroquine (n = 2; 20%), methotrexate (n = 3; 15%), and TNF inhibitors (n = 2; 10%). A complete/partial joint response was noted in 14 (70%) cases with a DAS44-CRP reduction of 2.07 [1.85–2.44] (from 3.13 [2.76–3.42] to 1.06 [0.9–1.17]; p < 0.05).Conclusion: Sarcoid arthropathies have different clinical phenotypes in acute and chronic forms and various treatment regimens such as hydroxychloroquine and methotrexate could be used in chronic forms.

Annular erythema nodosum leprosum reaction in a young male: a rare presentation

2018 ◽  
Vol 57 (4) ◽  
pp. 500-501
Author(s):  
Gnaneshwar R. Angoori ◽  
Farheen S. Syeda ◽  
Amit Kolli ◽  
Aparna Karanam ◽  
Uday R. Deshmukh ◽  
...  
Keyword(s):  
Erythema Nodosum ◽  
Young Male ◽  
Rare Presentation ◽  
Erythema Nodosum Leprosum ◽  
Annular Erythema

scholarly journals Adult Onset Henoch-Schonlein Purpura and Intussusception: A Rare Presentation

2016 ◽  
Vol 2016 ◽  
pp. 1-3 ◽  
Author(s):  
Mridula Krishnan ◽  
Joseph Nahas
Keyword(s):  
Unusual Case ◽  
Surgical Intervention ◽  
Gastrointestinal Symptoms ◽  
Adult Onset ◽  
Henoch Schonlein Purpura ◽  
Rare Presentation ◽  
Prompt Treatment ◽  
Life Threatening ◽  
Schonlein Purpura ◽  
Henoch Schönlein Purpura

We present an unusual case of a young 26-year-old male who was diagnosed with Henoch-Schonlein Purpura (HSP). Initial presentation was primarily mild gastrointestinal symptoms, which progressed to a life threatening intussusception and subsequently resolved with prompt glucocorticoid use rather than typical surgical intervention. Of importance, the patient’s initial gastrointestinal symptoms without associated skin manifestations made the diagnosis difficult. In conclusion, it is important to recognize uncommon presentations of HSP as it may lead to life threatening complications and surgical intervention may be avoided with prompt treatment.

scholarly journals Löfgren’s Syndrome: Acute Variant of Sarcoidosis

1970 ◽  
Vol 11 (2) ◽  
pp. 193-195 ◽  
Author(s):  
M Azizul Haque ◽  
M Golam Mostafa ◽  
ARM Saifuddin Ekram ◽  
AKM Shohidur Rahman Tarafdar
Keyword(s):  
Erythema Nodosum ◽  
Hilar Lymphadenopathy ◽  
Löfgren’S Syndrome ◽  
Acute Form

Löfgren’s syndrome is an acute form of sarcoidosis that is characterized by erythema nodosum, bilateral hilarlymphadenopathy accompanied by arthritis or arthralgia. We are reporting a 32 year old male with Löfgren’ssyndrome and then the literature is reviewed.Keywords: Löfgren’s syndrome; sarcoidosis; erythema nodosum; hilar lymphadenopathy; BangladeshDOI: 10.3329/jom.v11i2.5472J MEDICINE 2010; 11 : 193-195

scholarly journals Acute-onset Sarcoidosis with Erythema Nodosum and Polyarthralgia (Löfgren's Syndrome) in Japan: a Case Report and a Review of the Literature

2006 ◽  
Vol 45 (9) ◽  
pp. 659-662 ◽  
Author(s):  
Hiromitsu Ohta ◽  
Ryushi Tazawa ◽  
Atsushi Nakamura ◽  
Yuichiro Kimura ◽  
Makoto Maemondo ◽  
...  
Keyword(s):  
Case Report ◽  
Erythema Nodosum ◽  
Acute Onset ◽  
Review Of The Literature ◽  
Löfgren’S Syndrome

Macrophage migration inhibitory factor (MIF) -173 polymorphism is associated with clinical erythema nodosum in Löfgren’s syndrome

Cytokine ◽  
2014 ◽  
Vol 69 (2) ◽  
pp. 272-276 ◽  
Author(s):  
B. Karakaya ◽  
C.H.M. van Moorsel ◽  
A.H.M. van der Helm-van Mil ◽  
T.W.J. Huizinga ◽  
H.J.T. Ruven ◽  
...  
Keyword(s):  
Migration Inhibitory Factor ◽  
Macrophage Migration Inhibitory Factor ◽  
Erythema Nodosum ◽  
Inhibitory Factor ◽  
Macrophage Migration ◽  
Löfgren’S Syndrome

The diagnostic value of gastrocnemius muscle biopsy in sarcoidosis presenting with erythema nodosum and hilar adenopathy

1987 ◽  
Vol 6 (2) ◽  
pp. 192-196 ◽  
Author(s):  
A. P. Andonopoulos ◽  
G. Asimakopoulos ◽  
C. Mallioris ◽  
C. Karatza ◽  
C. Skopa
Keyword(s):  
Muscle Biopsy ◽  
Gastrocnemius Muscle ◽  
Erythema Nodosum ◽  
Diagnostic Value ◽  
Hilar Adenopathy

scholarly journals Lofgren’s syndrome: A case report and review of the literature

2021 ◽  
Vol 2 (6) ◽  
Author(s):  
Dong Bingzi ◽  
◽  
Zhao Qian ◽  
Wang Mei ◽  
Li Jinfeng ◽  
...  
Keyword(s):  
Erythema Nodosum ◽  
Symptomatic Relief ◽  
Elevated Serum ◽  
Acute Onset ◽  
Serum Angiotensin Converting Enzyme ◽  
Asian Patients ◽  
First Choice ◽  
Löfgren’S Syndrome ◽  
Classical Triad ◽  
Almost All

Lofgren’s syndrome is a variant of acute-onset sarcoidosis, characterized as Hilar Lymphadenopathy (HL), Erythema Nodosum (EN) and bilateral arthritis or arthralgia, with elevated serum Angiotensin Converting Enzyme (ACE) and calcium level. It is relatively common in Caucasians, but rarely reported in Asian countries. We reported a 72-year old Chinese female with HL, acute onset EN, multiple arthritis and arthralgia, and achieved remission with prednisolone treatment. We summarized reported cases in European and Asia countries, and investigated the characteristics of etiology, genetics, prognosis and therapeutic strategy variants due to different ethnicities. Almost all the patients showed HL, and half of them exhibited classical triad. ACE, the biomarker of Lofgren’s syndrome, elevated in more than half of the European cases, but only 30% in Asian patients. NASID is considered as the first choice of Lofgren’s syndrome, and glucocorticoid may be necessary in severe cases. One quarter of the cases from European countries need steroid therapy. However, the proportion is much higher (64.3%) to achieve symptomatic relief. Considering Lofgren’s syndrome is rare and less recognized from sarcoidosis in Asian patients, further investigation is needed to achieve clinical experience. Keywords: lofgren’s syndrome; lymphadenopathy; erythema nodosum; arthritis; sarcoidosis.

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