scholarly journals Fluorinated Ionic Liquids as Task-Specific Materials: An Overview of Current Research

2021 ◽  
Author(s):  
Nicole S.M. Vieira ◽  
Margarida L. Ferreira ◽  
Paulo J. Castro ◽  
João M.M. Araújo ◽  
Ana B. Pereiro
Keyword(s):  
Drug Delivery ◽  
Thermal Stability ◽  
Surface Tension ◽  
Ionic Liquids ◽  
Surface Activity ◽  
Vapour Pressure ◽  
Drug Delivery Systems ◽  
Delivery Systems ◽  
High Thermal Stability ◽  
Gas Solubility

This chapter is focused on the massive potential and increasing interest on Fluorinated Ionic Liquids (FILs) as task-specific materials. FILs are a specific family of ionic liquids, with fluorine tags equal or longer than four carbon atoms, that share and improve the properties of both traditional ionic liquids and perfluoro surfactants. These compounds have unique properties such as three nanosegregated domains, a great surfactant power, chemical/biological inertness, easy recovery and recyclability, low surface tension, extreme surface activity, high gas solubility, negligible vapour pressure, null flammability, and high thermal stability. These properties allied to the countless possible combinations between cations and anions allow the design and development of FILs with remarkable properties to be used in specific applications. In this review, we highlight not only the unique thermophysical, surfactant and toxicological properties of these fluorinated compounds, but also their application as task-specific materials in many fields of interest, including biomedical applications, as artificial gas carries and drug delivery systems, as well as solvents for separations in engineering processes.

Design Principles for Ionic Liquids in Drug Delivery Systems

2021 ◽  
pp. 1-12
Author(s):  
Md. Raihan Chowdhury ◽  
Md. Nurunnabi ◽  
Masahiro Goto
Keyword(s):  
Drug Delivery ◽  
Ionic Liquids ◽  
Drug Delivery Systems ◽  
Design Principles ◽  
Delivery Systems

scholarly journals New Opportunity to Formulate Intranasal Vaccines and Drug Delivery Systems Based on Chitosan

2020 ◽  
Vol 21 (14) ◽  
pp. 5016
Author(s):  
Roxana Popescu ◽  
Mihaela Violeta Ghica ◽  
Cristina-Elena Dinu-Pîrvu ◽  
Valentina Anuța ◽  
Dumitru Lupuliasa ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Surface Tension ◽  
Zeta Potential ◽  
Conformational Changes ◽  
Drug Delivery Systems ◽  
Delivery Systems ◽  
Active Pharmaceutical Ingredients ◽  
Nasal Drug Delivery ◽  
Pharmaceutical Ingredients ◽  
Permeability Enhancement

In an attempt to develop drug delivery systems that bypass the blood–brain barrier (BBB) and prevent liver and intestinal degradation, it was concluded that nasal medication meets these criteria and can be used for drugs that have these drawbacks. The aim of this review is to present the influence of the properties of chitosan and its derivatives (mucoadhesion, permeability enhancement, surface tension, and zeta potential) on the development of suitable nasal drug delivery systems and on the nasal bioavailability of various active pharmaceutical ingredients. Interactions between chitosan and proteins, lipids, antigens, and other molecules lead to complexes that have their own applications or to changing characteristics of the substances involved in the bond (conformational changes, increased stability or solubility, etc.). Chitosan and its derivatives have their own actions (antibacterial, antifungal, immunostimulant, antioxidant, etc.) and can be used as such or in combination with other molecules from the same class to achieve a synergistic effect. The applicability of the properties is set out in the second part of the paper, where nasal formulations based on chitosan are described (vaccines, hydrogels, nanoparticles, nanostructured lipid carriers (NLC), powders, emulsions, etc.).

Drug delivery systems based on pharmaceutically active ionic liquids and biocompatible poly(lactic acid)

2014 ◽  
Vol 2 (20) ◽  
pp. 3133-3141 ◽  
Author(s):  
Claire Jouannin ◽  
Corine Tourné-Péteilh ◽  
Vincent Darcos ◽  
Tahmer Sharkawi ◽  
Jean-Marie Devoisselle ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Ionic Liquids ◽  
Lactic Acid ◽  
Controlled Release ◽  
Drug Delivery Systems ◽  
Delivery Systems ◽  
Poly Lactic Acid

API-ILs were encapsulated into biocompatible PLLA. The morphology and crystallinity of the resulting membranes can be tuned by varying the IL nature and content leading to controlled release.

Advances Brought by Ionic Liquids in the Development of Polymer-Based Drug Delivery Systems

2021 ◽  
pp. 113-135
Author(s):  
Sónia N. Pedro ◽  
Carmen S. R. Freire ◽  
Armando J. D. Silvestre ◽  
Mara G. Freire
Keyword(s):  
Drug Delivery ◽  
Ionic Liquids ◽  
Drug Delivery Systems ◽  
Delivery Systems

Ionic liquids as a potential tool for drug delivery systems

MedChemComm ◽  
2016 ◽  
Vol 7 (10) ◽  
pp. 1881-1897 ◽  
Author(s):  
Noorul Adawiyah ◽  
Muhammad Moniruzzaman ◽  
Siti Hawatulaila ◽  
Masahiro Goto
Keyword(s):  
Drug Delivery ◽  
Ionic Liquids ◽  
Drug Delivery Systems ◽  
Delivery Systems ◽  
Drug Molecules ◽  
Pharmaceutical Industries ◽  
Low Solubility ◽  
Potential Tool

The pharmaceutical industries face a series of challenges in the delivery of many newly developed drug molecules because of their low solubility, bioavailability, stability and polymorphic conversion.

Ionic liquids as ingredients in topical drug delivery systems

2013 ◽  
Vol 441 (1-2) ◽  
pp. 620-627 ◽  
Author(s):  
Dorota Dobler ◽  
Thomas Schmidts ◽  
Ines Klingenhöfer ◽  
Frank Runkel
Keyword(s):  
Drug Delivery ◽  
Ionic Liquids ◽  
Drug Delivery Systems ◽  
Delivery Systems ◽  
Topical Drug Delivery

scholarly journals Electrical Conductivity and Nyquist Plot of C4C1Im BF4 at Room Temperature by Impedance Spectroscopy

2020 ◽  
Vol 3 (1) ◽  
pp. 119
Author(s):  
Pablo Vallet ◽  
Juan José Parajó ◽  
Félix Sotuela ◽  
Angel Morcillo ◽  
María Villanueva ◽  
...  
Keyword(s):  
Thermal Stability ◽  
Electrical Conductivity ◽  
Ionic Liquids ◽  
Ionic Conductivity ◽  
Impedance Spectroscopy ◽  
Vapour Pressure ◽  
Room Temperature ◽  
Nyquist Plot ◽  
High Thermal Stability ◽  
Wide Potential

Ionic liquids (ILs) represent a real alternative for electrochemical applications due to their remarkable characteristics, namely a very low vapour pressure, low flammability, high thermal stability, wide potential window and high ionic conductivity. In this work, Nyquist plot and impedance spectroscopy at room temperature is proposed as an alternative method to obtain the ionic conductivity for ionic liquids by using an Agilent HP 4284A RLC precision meter. For this propose, the IL 1-butyl-3-methylimidazolium tetrafluoroborate (C4C1Im BF4) was selected and results were compared with the previously obtained from the conductimeter CRISON GLP31.

scholarly journals Ionic Liquids in Drug Delivery

Encyclopedia ◽  
2021 ◽  
Vol 1 (2) ◽  
pp. 324-339
Author(s):  
Sónia N. Pedro ◽  
Carmen S. R. Freire ◽  
Armando J. D. Silvestre ◽  
Mara G. Freire
Keyword(s):  
Drug Delivery ◽  
Ionic Liquids ◽  
Drug Delivery Systems ◽  
Organic Cation ◽  
Delivery Systems ◽  
Ionic Character ◽  
Atmospheric Conditions ◽  
Routes Of Administration ◽  
Pharmaceutical Ingredients ◽  
Novel Drug

Ionic liquids (ILs) are molten salts composed of a large organic cation and an organic/inorganic anion. Due to their ionic character, most ILs present advantageous properties over conventional solvents, such as negligible volatility at atmospheric conditions and high thermal and chemical stabilities. The wide variety of IL anion–cation combinations allows these solvents to be designed to display a strong solvation ability for a myriad of active pharmaceutical ingredients (APIs) and (bio)polymers. Given these properties, ILs have been used as solvents and as formulation components in different areas of drug delivery, as well as novel liquid forms of APIs (API-ILs) applied in different stages of development of novel drug delivery systems. Furthermore, their combination with polymers and biopolymers has enabled the design of drug delivery systems for new therapeutic routes of administration.

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