scholarly journals Frequency of Hyperglycemia in Patients with Covid-19 Infection and Pneumonia

2021 ◽  
Author(s):  
Valeriy Ivanovich Vechorko ◽  
Evgeny Mikhailovich Evsikov ◽  
Oksana Alekseevna Baykova ◽  
Natalya Vadimovna Teplova ◽  
Dmitriy Aleksandrovich Doroshenko
Keyword(s):  
Diabetes Mellitus ◽  
Glucose Tolerance ◽  
Impaired Glucose Tolerance ◽  
Carbohydrate Metabolism ◽  
Age Groups ◽  
Newly Diagnosed ◽  
Glucose Levels ◽  
Control And Prevention ◽  
Diagnosed Diabetes ◽  
Newly Diagnosed Diabetes

Diabetes mellitus can increase the risk of death in COVID-19 by 12 times, according to the portal of the us Centers for disease control and prevention. Coronavirus-infected diabetics are six times more likely to need inpatient treatment, and diabetes is the second most severe complication in COVID-19 after cardiovascular diseases. The state of carbohydrate metabolism in patients with COVID-19 has not been sufficiently studied in clinical studies. Isolated studies indicate that viral infection may be accompanied by an increase in the concentration of glycated hemoglobin in patients with viral pneumonia. To assess the frequency of hyperglycemia and diagnosis of newly diagnosed diabetes mellitus in patients with COVID-19 and acute lung damage aged 41–80 years, who were hospitalized in a repurposed infectious diseases hospital in Moscow with a diagnosis of pneumonia. In the observational study analyzed laboratory and clinical diagnostic data of 278 patients who had, according to the anamnesis and the medical conclusions of impaired glucose tolerance and manifested forms of diabetes, including 163 men and 115 women, aged 41–80 years, admitted to the hospital for diagnosis and treatment in the period from 12.04.2020 on 10.11.2020 of diagnoses according to ICD-10: U07.1 Coronavirus infection. In the selected groups of patients, the initial and subsequent fasting blood glucose levels were analyzed after 8 hours without food intake on a stationary automatic analyzer and using portable glucose, meters using diagnostic test strips. The concentration of glucose and ketones in the urine was determined by a semi-quantitative method. We evaluated the dynamics of indicators when detecting pathological values of glucose concentration. Glucose levels above 6.4 mmol/l were taken as pathological. In patients aged 41–80 years who were hospitalized with covid-19 infection and pneumonia, fasting hyperglycemia was diagnosed in 31–47%, glucosuria in 1.9–6.1%, ketonuria – 20.4-46.2% of cases, in different age groups. In 16.6–31.3% of cases in patients with covid-19,after treatment and regression of changes in the lungs, normalization of glucose levels was observed, but in 14.8–16.7% of the changes persisted, and in 9–13% of them, after an additional study, newly diagnosed diabetes mellitus was diagnosed. Hyperglycemia was significantly more often detected in patients with arterial hypertension of 2–3 degrees of severity and with a tendency to reliability, in patients with obesity of 2–3 degrees. Lipid metabolism disorders (hypertriglyceridemia and hypercholesterolemia), which are characteristic of changes in carbohydrate metabolism in patients with impaired glucose tolerance and diabetes, were significantly more often diagnosed in patients with covid-19 than in the group of patients with acute and chronic lung pathology without proven infection with this virus, but only in the group of patients aged 41–60 years. Covid-19 infection complicated by pneumonia occurs in individuals aged 41–80 years with a high incidence of hyperglycemia and ketonuria. The incidence of newly diagnosed diabetes mellitus in such patients is 9–13%.

scholarly journals Levels Of Resistin And Visfatin In Patients With Metabolic Syndrome

2015 ◽  
Vol 8 (1) ◽  
pp. 40-45
Author(s):  
Ginka H. Rayanova ◽  
Silvia S. Ganeva ◽  
Katya N. Todorova ◽  
Tsvetan H. Lukanov ◽  
Svetla P. Gecheva
Keyword(s):  
Diabetes Mellitus ◽  
Metabolic Syndrome ◽  
Glucose Tolerance ◽  
Impaired Glucose Tolerance ◽  
Diabetes Mellitus Type 2 ◽  
Diabetes Mellitus Type ◽  
Newly Diagnosed ◽  
Diagnosed Diabetes ◽  
Newly Diagnosed Diabetes

SummaryThe aim of the study is to investigate the serum levels of adipokines-resistin and visfatin in patients with metabolic syndrome. A prospective study was performed, including 153 (103 female, 50 male) subjects with metabolic syndrome. Carbohydrate metabolism was estimated by oral glucose tolerance test with 75g of glucose. Of the subjects investigated, 40 were with normal glycaemic tolerance, 40 - with impaired fasting glycaemia, 28 - with impaired glucose tolerance and 45 - with newly diagnosed diabetes mellitus type 2. The results were compared to those in a control group of 20 subjects without findings indicating metabolic syndrome. The serum levels of resistin and visfatin were measured with an enzyme immunoassay method (ELISA, BioVendor Laboratory Medicine, Inc., Czech Republic). There were significant differences in body mass index, waist circumference, systolic blood pressure, plasma level of blood glucose and serum level of triglycerides between the examined subjects with metabolic syndrome, as compared with the control group. The amount of serum resistin in subjects with metabolic syndrome and newly diagnosed diabetes mellitus type 2 was significantly higher, as compared to the controls. Subjects with metabolic syndrome and pathological glucose tolerance-impaired fasting glycaemia, impaired glucose tolerance and newly diagnosed diabetes mellitus type 2 were found with a significantly higher serum level of visfatin, as compared to normal glucose tolerance and to the controls. Subjects with metabolic syndrome and pathological glucose tolerance-impaired fasting glucose, impaired glucose tolerance and newly diagnosed diabetes mellitus type 2 exhibited significantly changes in serum levels of adipokines-resistin and visfatin.

scholarly journals Screening of newly-diagnosed adults with Tuberculosis for Diabetes mellitus and Impaired Glucose Tolerance in a Local Government Area in Ogun State, Nigeria

2019 ◽  
pp. 146-155
Author(s):  
AA Salako ◽  
OA Adenowo ◽  
OE Amoran ◽  
O Odusan ◽  
GJ Mautin ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Blood Glucose ◽  
Glucose Tolerance ◽  
Impaired Glucose Tolerance ◽  
Treatment Outcomes ◽  
Fasting Blood Glucose ◽  
Newly Diagnosed ◽  
Glucose Levels ◽  
Ogun State ◽  
Blood Glucose Levels

Background: Emerging patterns in epidemiological transitions have led to increased risk for Non-Communicable Diseases and infectious conditions globally. Diabetes mellitus (DM) in a population is one such risk factor that could lead to the development of Tuberculosis (TB) due to weakened immune functions in affected persons, with implications for mortality. If not diagnosed early, DM also leads to poor treatment outcomes in TB. Objective: To assess the prevalence of DM and impaired glucose tolerance (pre-diabetes) among newly diagnosed tuberculosis cases in Ijebu-Ode Local Government Area of Ogun State, Nigeria. Methods: This cross-sectional study was conducted among 100 newly diagnosed Pulmonary TB patients in ljebu-Ode LGA. The patients were selected from four health facilities and were screened for elevated Fasting Blood Glucose levels using a laboratory spectrophotometer (glucose oxidase method). Results: The mean age of the 100 study participants was 33 years (± 9.82), with ages within 19 -62 years. Eleven (11.0%) had elevated blood glucose levels suggestive of DM, while 20 (20.0%) had impaired fasting blood glucose levels. Among these 31 patients, 18 (58.0%) were males while 13 (42.0%) were females. The modal ages were within 20-39 years. Conclusion: Screening for DM by healthcare providers should be routinely conducted before commencing TB patients on treatment. This will aid early detection, improve treatment outcomes of TB and prevent mortality among patients with these co-morbidities.

Increased cardiotrophin-1 in subjects with impaired glucose tolerance and newly diagnosed diabetes

2013 ◽  
Vol 169 (3) ◽  
pp. e33-e34 ◽  
Author(s):  
Hao-Chang Hung ◽  
Feng-Hwa Lu ◽  
Horng-Yih Ou ◽  
Hung-Tsung Wu ◽  
Jin-Shang Wu ◽  
...  
Keyword(s):  
Glucose Tolerance ◽  
Impaired Glucose Tolerance ◽  
Newly Diagnosed ◽  
Diagnosed Diabetes ◽  
Newly Diagnosed Diabetes

Diagnosis and treatment of water and electrolyte disorders in stroke patients with diabetes mellitus

2016 ◽  
pp. 65-68
Author(s):  
O. Halushko ◽  
Keyword(s):  
Diabetes Mellitus ◽  
Acute Stroke ◽  
Carbohydrate Metabolism ◽  
Second Phase ◽  
Newly Diagnosed ◽  
Stroke Patients ◽  
Electrolyte Disorders ◽  
Electrolyte Disturbances ◽  
Diagnosed Diabetes ◽  
Newly Diagnosed Diabetes

The objective: to study the origin and characteristics of the flow of electrolyte abnormalities in patients with acute stroke (OR) on a background of concomitant diabetes mellitus (DM) and the possibility of their correction. Patients and methods. Electrolyte disturbances that occur in patients with acute stroke (AS) is one of the reasons complications of AS. Concomitant diabetes mellitus (DM) affects the severity of stroke and increased mortality rates. Analysis of 416 patients with the treatment of AS was conducted. All patients were divided into three groups: 1) patients with established diabetes before the stroke, 2) patients with newly diagnosed diabetes and 3) patients without diabetes. The second phase was conducted a pilot study with an analysis of the frequency of magnesium and phosphate metabolic disorders in the patients with AS (20 patients with AS on a background of diabetes and 10 stroke patients without diabetes). Results. In general, the different types of electrolyte disorders were observed in 73.9% patients with AS, while in patients with underlying disorders of carbohydrate metabolism, these violations occurred significantly more often than patients without such. In particular, carbohydrate metabolism occurred in 82 (81.2%) and 36 (83.7%) patients 1 and 2 groups versus 134 (65.4%) in the control group (p<0.05). Hypomagnesemia (less than 0.8 mmol/L) was observed in 2 of 10 patients (20%) in AS without carbohydrate disturbances and in 6 of 20 patients (30%) in AS with concomitant diabetes. Hypophosphatemia (phosphate levels less than 0,8 mmol/L) was found in patients without diabetes and AS in 2 patients with concomitant DM or newly diagnosed diabetes. Following the correction of oral medication containing phosphates and magnesium blood electrolyte levels was stabilized and that coincided with the improvement of the patients and the degree of disability. Conclusion: Electrolyte disorders are fairly common problem in patients with concomitant diabetes and AS. In patients with impaired carbohydrate metabolism observed significantly higher frequency (more than 81,2% of patients) occurrence of electrolyte disorders than patients without them. Conclusion. In the case of AS on a background of diabetes electrolyte disturbances occur significantly more frequently than in patients without such comorbid disorders. Key words: stroke, electrolytes, sodium, potassium, chloride, magnesium, phosphate.

scholarly journals Increased risk of glomerular hyperfiltration in subjects with impaired glucose tolerance and newly diagnosed diabetes

2015 ◽  
Vol 31 (8) ◽  
pp. 1295-1301 ◽  
Author(s):  
Zih-Jie Sun ◽  
Yi-Ching Yang ◽  
Jin-Shang Wu ◽  
Ming-Cheng Wang ◽  
Chih-Jen Chang ◽  
...  
Keyword(s):  
Glucose Tolerance ◽  
Impaired Glucose Tolerance ◽  
Glomerular Hyperfiltration ◽  
Newly Diagnosed ◽  
Increased Risk ◽  
Diagnosed Diabetes ◽  
Newly Diagnosed Diabetes
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