scholarly journals Three-Dimensionally Ordered Macroporous-Mesoporous Bioactive Glass Ceramics for Drug Delivery Capacity and Evaluation of Drug Release

2020 ◽  
Author(s):  
Reedwan Bin Zafar Auniq ◽  
Namon Hirun ◽  
Upsorn Boonyang
Keyword(s):  
Drug Release ◽  
Bioactive Glass ◽  
Drug Loading ◽  
Diffusion Mechanism ◽  
Sol Gel ◽  
Glass Ceramics ◽  
Fickian Diffusion ◽  
Ordered Macroporous ◽  
Mesoporous Bioactive Glass

Bioactive glass ceramics (BGCs) have been used in orthopedic and dentistry due to having better osteoconductive and osteostimulative properties. This study aimed to evaluate and compare the drug release properties of two different BGCs; 45S5 and S53P4. The BGCs were composed with four phases of SiO2 – CaO – Na2O – P2O5 system, synthesized by sol–gel method using dual templates; a block-copolymer as mesoporous templates and polymer colloidal crystals as macroporous templates, called three-dimensionally ordered macroporous-mesoporous bioactive glass ceramics (3DOM-MBGCs). In vitro bioactivity test performed by soaking the 3DOM-MBGCs in simulated body fluid (SBF) at 37°C. The results indicated that, the 45S5 have the ability to grow hydroxyapatite-like layer on the surfaces faster than S53P4. Gentamicin drug was used to examine in vitro drug release properties in phosphate buffer solution (PBS). The amount of drug release was quantified through UV/Vis spectroscopy by using o-phthaldialdehyde reagent. S53P4 showed high drug loading content. The outcome of drug release in PBS showed that both S53P4 and 45S5 exhibited a slowly continuous gentamicin release. The resultant drug release profiles were fitted to the Peppas-Korsmeyer model to establish the predominant drug release mechanisms, which revealed that the kinetics of drug release from the glasses mostly dominated by Fickian diffusion mechanism.

Development and Evaluation of Controlled Release Mucoadhesive Tablets of Captopril

1970 ◽  
Vol 9 (3) ◽  
pp. 3318-3329
Author(s):  
Kranthi Kumar Kotta ◽  
L. Srinivas
Keyword(s):  
Controlled Release ◽  
Drug Release ◽  
Xanthan Gum ◽  
Diffusion Mechanism ◽  
Matrix Tablets ◽  
Fickian Diffusion ◽  
Content Uniformity ◽  
In Vitro Drug Release ◽  
Mucoadhesive Tablets

The present investigation focuses on the development of mucoadhesive tablets of captopril which are designed to prolong the gastric residence time after oral administration. Matrix tablets of captopril were formulated using four mucoadhesive polymers namely guar gum, xanthan gum, HPMC K4M and HPMC K15M and studied for parameters such as weight variation, thickness, hardness, content uniformity, swelling index, mucoadhesive force and in vitro drug release. Tablets formulated Xanthan gum or HPMC K4M with HPMC K15M provide slow release of captopril over period of 12 hr and were found suitable for maintenance portion of oral controlled release tablets. The cumulative % of drug release of formulation F9 and F10 were 90 and 92, respectively. In vitro release from these tablets was diffusion controlled and followed zero order kinetics. The ‘n’ values obtained from the pappas-karsemeyer equation suggested that all the formulation showed drug release by non-fickian diffusion mechanism. Tablets formulated Xanthan gum or HPMC K4M with HPMC K15M (1:1) were established to be the optimum formulation with optimum bioadhesive force, swelling index & desired invitro drug release. This product was further subjected to stability study, the results of which indicated no significant change with respect to Adhesive strength and in vitro drug release study.

scholarly journals The Evaluation of Formation and Bioactivity of New Sol-gel Bioactive Glass

2019 ◽  
Vol 35 (1) ◽  
Author(s):  
Bui Xuan Vuong
Keyword(s):  
Bioactive Glass ◽  
Sol Gel ◽  
Glass Ceramics ◽  
Medical Applications ◽  
Crystalline Solids ◽  
Bioactive Glasses ◽  
Central European Journal ◽  
Central European

In this paper, three ceramic compositions 50SiO2-50CaO (A), 45SiO2-45CaO-10P2O5 (B) and 40SiO2-40CaO-20P2O5 (C) (wt %) were synthesized by using the sol-gel technique. XRD analysis demonstrates that only sample C can form the glass material. Treated temperatures and heated times were also evaluated. Analysis data showed that the bioglass 40SiO2-40CaO-20P2O5 (wt %) can successfully elaborate when the ceramic powder heated at 750 oC for 3 hours. ‘‘In vitro’’ experiment was effectuated to investigate the bioactivity of bioglass 40SiO2-40CaO-20P2O5 by soaking powder samples in SBF solution. Obtained result confirmed the formation of hydroxyapatite (HA) phase on glass’s surface after 15 days of immersion, in which HA formation orients following (211) and (222) miller planes in crystalline structure of HA phase. Keywords Sol-gel; bioglass; hydroxyapatite; SBF; bioactivity References [1] D.F. Williams, Definitions in Biomaterials, Consensus Conference for the European Society for Biomaterials, Chester, UK, 1986.[2] L.L. Hench, Bioceramics: From Concept to Clinic, Journal of the American Ceramic Society, 74 (1991) 1487.[3] L.L. Hench, The story of Bioglass, Journal of Materials Science: Materials in Medicine, 17 (2006) 967.[4] X.V. Bui, H. Oudadesse, Y. Le Gal, A. Mostafa, P.Pellen and G. Cathelineau, Chemical Reactivity of Biocomposite Glass-Zoledronate, Journal of the Australian Ceramic Society, 46 (2010) 24.[5] L.L. Hench, Genetic design of bioactive glass, Journal of the European Ceramic Society, 29 (2009) 1257.[6] S. Kumar, P. Vinatier, A. Levasseur, K.J. Rao, Investigations of structure and transport in lithium and silver borophosphate glasses, Journal of Solid State Chemistry, 177 (2004)1723.[7] Z. Hong, A. Liu, L. Chen, X. Chen, X. Jing, Preparation of bioactive glass ceramic nanoparticles by combination of sol–gel and coprecipitation method, Journal of Non-Crystalline Solids, 355 (2009) 368.[8] D.B. Joroch, D.C. Clupper, Modulation of zinc release from bioactive sol–gel derived SiO2‐CaO‐ZnO glasses and ceramics, Journal of Biomedical Materials Research Part A, 82A (2007) 575.[9] J. Roman, S. Padilla, M. Vallet-Regi, Sol−Gel Glasses as Precursors of Bioactive Glass Ceramics, Chemistry of Materials, 15 (2003) 798.[10] J. Lao, J.M. Nedelec, Ph. Moretto, E. Jallot, Biological activity of a SiO2-CaO-P2O5 sol-gel glass highlighted by PIXE-RBS methods, Nuclear Instruments and Methods in Physics Research Section B, 245 (2006) 511.[11] [11] M. Vallet-Regi, L. Ruiz-Gonzalez, I. Izquierdo, J.M. Gonzalez-Calbet, Revisiting silica based ordered mesoporous materials: medical applications, Journal of Materials Chemistry, 16 (2006) 26.[12] W. Xia, J. Chang, Preparation and characterization of nano-bioactive-glasses (NBG) by a quick alkali-mediated sol–gel method, Materials Letters 61 (2007) 3251.[13] R. Li, A.E. Clark, L.L. Hench, An investigation of Bioactive Glass Powders by Sol-Gel Processing, Transactions of 16th Annual Meeting of the Societey for Biomaterials, 12 (1990) 40.[14] J. Lao, J.M. Nedelec, P. Moretto, E. Jallot, Imaging physicochemical reactions occurring at the pore surface in binary bioactive glass foams by micro ion beam analysis, Applied Materials and Interfaces, 6 (2010) 1737.[15] A. Balamurugan, G. Balossier, S. Kannan, J. Michel, A.H.S. Rebelo, J.M.F. Ferreira, Development and in vitro characterization of sol–gel derived CaO–P2O5–SiO2–ZnO bioglas, Acta Biomaterialia, 3 (2007) 255.[16] Z. Hong, A. Liu, L. Chen, X. Chen, X. Jing, Bioactive glass prepared by sol–gel emulsion, Journal of Non-Crystalline Solids, 355 (2009) 368.[17] O. Peital, E.D. Zanotto, L.L. Hench, Highly bioactive P2O5-Na2O-CaO-SiO2 glass-ceramics, Journal of Non-Crystalline Solids, 292 (2001) 115.[18] J. Liu, X. Miao, Sol-gel derived bioglass as a coating material for porous alumina scaffolds, Ceramics International, 30 (2004) 1781.[19] T. Kokubo, H. Takadama, How useful is SBF in predicting in vivo bone bioactivity. Biomaterials 27 (2006) 2907.[20] M. Dziadek, B. Zagrajczuk, P. Jelen, Z. Olejniczak, K.C. Kowalska, Structural variations of bioactive glasses obtained by different synthesis routes, Ceramics International, 42 (2016) 14700.[21] R. Lakshmi, V. Velmurugan and S. Sasikumar, Preparation and Phase Evolution of Wollastonite by Sol-Gel Combustion Method Using Sucrose as the Fuel, Combustion Science and Technology, 185 (2013) 1777.[22] G. Voicu, A. Bădănoiu, E. Andronescu1, C. M. Chifiruc, Synthesis, characterization and bioevaluation of partially stabilized cements for medical applications, Central European Journal of Chemistry, 11 (2013) 1657.[23] M.V. Regi, Ceramics for medical applications, Journal of the Chemical Society, Dalton Transactions, 2 (2001) 97.[24] G. Voicu, A.I. Bădănoiu, E. Andronescu, C.M. Chifiruc, Synthesis, characterization and bioevaluation of partially stabilized cements for medical applications, Central European Journal of Chemistry, 11 (2013) 1657.M. Wu, T. Wang, Y. Wang, F. Li, M. Zhou, X. Wu, A novel and facile route for synthesis of fine tricalcium silicate powders, Materials letters, 227 (2018), 187.

scholarly journals Cytocompatibility and Dielectric Properties of Sr2+ Substituted Nano-Hydroxyapatite for Triggered Drug Release

2019 ◽  
Vol 1 (1) ◽  
pp. 18-24
Author(s):  
Lakshmanaperumal Sundarabharathi ◽  
Mahendran Chinnaswamy ◽  
Hemalatha Parangusan ◽  
Deepalekshmi Ponnamma ◽  
Mariam Al Ali Al-Maadeed
Keyword(s):  
Dielectric Properties ◽  
Drug Release ◽  
Drug Loading ◽  
Sol Gel ◽  
X Ray Diffraction ◽  
Sustained Drug Release ◽  
Model Drug ◽  
Dielectrical Properties ◽  
Living Tissues

Hydroxyapatite (Ca5(PO4)3OH) is a well-known bioceramics material used in medical applications because of its ability to form direct chemical bonds with living tissues. In this context, we investigate the biocompatibility and dielectric properties of Sr2+-substituted hydroxyapatite nanoparticles were synthesized by sol-gel method. The influence of strontium on the crystal structure, functional group, morphological, electrical properties, and biocompatibility of as-synthesized nano-hydroxyapatite samples was analyzed using X-ray diffraction (XRD), Fourier transform infrared (FTIR) spectroscopy and field emission scanning electron microscopy (FE-SEM). Dielectrical properties of the bioactive Sr-HA sample were investigated by a dielectric impedance spectroscopy method. The observed results illustrate the incorporation of Sr2+ ions in the apatite lattice could influence the pure HA properties, by reducing the crystallite size and crystallinity quite consistent with the morphology variation. The ac conductivity (σac) increased with an increasing applied frequency confirmed that prepared HA sample exhibited the universal power law nature. Further, the in vitro drug loading and release studies using doxycycline as a model drug demonstrate that the Sr2+ -HA nanoparticles show high drug adsorption capacity and sustained drug release. Thus, the improved bioceramics system could be a promising candidate for future biomedical applications.

Formulation and In vitro Evaluation of Floating Microspheres of Misoprostol

2017 ◽  
Vol 10 (1) ◽  
pp. 3608-3615
Author(s):  
K Vanitha ◽  
M. Mohan Varma ◽  
Ramesh Alluri
Keyword(s):  
Drug Release ◽  
High Performance ◽  
Chemical Interaction ◽  
Release Kinetics ◽  
Diffusion Mechanism ◽  
Methyl Cellulose ◽  
Ultra Violet ◽  
Fickian Diffusion ◽  
Polymer Ratio

Misoprostol is a synthetic prostaglandin PGE1 analogue, which has proved to be an effective anti-secretory agent for oral use. The major indications of Misoprostol are in the prevention and treatment of NSAID-induced gastric and duodenal ulcers. Its half-life is 20-40 minutes. More than one third of patients with ulcers are resistant to H2 antagonists. So, these patients can be healed on Misoprostol. The objective of the present study was to formulate gastroretentive floating drug delivery system of an antiulcer drug Misoprostol. Floating microspheres of Misoprostol were prepared by an emulsification solvent evaporation technique using hydroxy propyl methyl-cellulose (HPMC K 100M) and ethyl cellulose. The percentage yield and drug entrapment efficiencies of these floating microspheres were within the range between: 70 ± 2.8 to 98 ± 2.9 % and 39.27 to 82.39 %, respectively. The determined mean particle size for all the microspheres were 250 ± 7.28 to 400 ± 2.32 µm. The flowability of these microspheres was found good. A high performance liquid chromatography (HPLC) method with ultra-violet (UV) detection was selected for the method of analysis.  The drug release was found to delay for 12 hours with the increasing drug to polymer ratio. The drug release kinetics followed Korsemeyer-Peppas and Higuchi model with anomalous (non-Fickian) diffusion mechanism for the drug release. The FTIR and DSC studies showed that there was an absence of chemical interaction between the drug and the excipients. The in vitro drug release from Misoprostol floating microspheres showed the drug release was dependent on the drug to polymer ratio. The drug release was found delayed with the increasing drug to polymer ratio.  

Sinomenine-loaded microcapsules fabricated by phase reversion emulsification-drying in liquid method: An evaluation of process parameters, characterization, and released properties

2017 ◽  
Vol 33 (4) ◽  
pp. 382-396 ◽  
Author(s):  
Wen Zhang ◽  
Yan Gao ◽  
Ning Yang ◽  
Hua Zhang ◽  
Feng Zhang ◽  
...  
Keyword(s):  
Biological Activities ◽  
Drug Loading ◽  
Diffusion Mechanism ◽  
In Vitro Release ◽  
Spherical Shape ◽  
Fickian Diffusion ◽  
Anti Cancer ◽  
Methyl Thiazolyl Tetrazolium Assay ◽  
Natural Alkaloid

Sinomenine is a natural alkaloid with important biological activities (e.g. anti-cancer, anti-inflammatory, and anti-allergic). However, the unstability and short half-life absolutely limited its application to foods. Microencapsulation technology can offer a way to solve these issues. In this study, polylactic acid microcapsules loading sinomenine hydrochloride were fabricated by phase inversion emulsification-drying in liquid technique. The results showed that microcapsules had nice spherical shape, uniform particle size, and free flowing. The encapsulation efficiency was 89.2% and drug loading was 8.9% under the optimal conditions. In vitro release assays demonstrated that release of sinomenine from microcapsules was sustained and slow. Moreover, it was found that the sinomenine release fitted Fickian diffusion mechanism. The results of cytotoxicity study showed that sinomenine-loaded microcapsules were biocompatible. Sinomenine-loaded microcapsules could inhibit the growth of MDA-MB-231 cells using methyl thiazolyl tetrazolium assay. In summary, polylactide microcapsules exhibit excellent properties for sinomenine that can be used in drug or food industry.

scholarly journals Quenched/unquenched nano bioactive glass-ceramics: Synthesis and in vitro bioactivity evaluation in Ringer’s solution with BSA

2013 ◽  
Vol 19 (2) ◽  
pp. 231-239 ◽  
Author(s):  
Nima Nabian ◽  
Maedeh Delavar ◽  
Mahmood Rabiee ◽  
Mohsen Jahanshahi
Keyword(s):  
Electron Microscope ◽  
Bioactive Glass ◽  
Glass Ceramic ◽  
Sol Gel ◽  
Glass Ceramics ◽  
Apatite Formation ◽  
In Vitro Bioactivity ◽  
Sem Images ◽  
Transmission Electron

The paper reports the first attempt at changing cooling treatment of synthesizing method in order to investigate its effect on the physical properties of sol-gel derived nano bioactive glass-ceramic in the system 58SiO2-33CaO-9P2O5 (wt.%). We hypothesized that the method of cooling may affect the properties of nano bioactive glass-ceramic. To test this hypothesis, two different method of cooling treatment was applied after calcinations in synthesizing method. Both quenched and unquenched nano bioactive glass-ceramics were soaked in Ringer?s solution with bovine serum albumin (BSA) for bioactivity evaluation. The obtained samples were analyzed for their composition, crystalinity and morphology through X-ray powder diffraction (XRD), Fourier transform infrared spectroscopy (FTIR), surface electron microscope (SEM) and transmission electron microscope (TEM). The SEM images showed that the morphology of nano bioactive glass-ceramics was completely changed by quenching process. Results of in vitro bioactivity evaluation revealed that the unquenched attains faster apatite formation ability than the quenched sample. Other properties of these two morphologically different nano bioactive glass-ceramics were strongly discussed.

scholarly journals FORMULATION DEVELOPMENT AND IN VITRO EVALUATION OF ALENDRONATE BUCCAL TABLETS

2019 ◽  
Vol 9 (4-s) ◽  
pp. 363-369
Author(s):  
SANJAY KUMAR GUPTA ◽  
Sradhanjali Patra ◽  
Syed Adnan Akber
Keyword(s):  
Drug Release ◽  
Sodium Alginate ◽  
Ethyl Cellulose ◽  
Diffusion Mechanism ◽  
Fickian Diffusion ◽  
Extensive Literature ◽  
Formulation Development ◽  
Alendronate Sodium ◽  
Buccal Tablets

The aim of this work was to develop a mucoadhesive buccal tablet for the buccal delivery of the alendronate via buccal mucosa. Buccal tablets of alendronate are designed to release drug at mucosal site for extended period of time without wash out of drug by saliva. Alendronate sodium is a bisphosphonates which has antiresorptive effect which is implicated in the prophylaxis and treatment of osteoporosis. Sodium alginate, ethyl cellulose and carbopol were selected as mucoadhesive polymers on the basis of their matrix forming properties. The objective of the study is to improve the bioavailability of alendronate buccal tablets. Extensive literature survey was done for the collection of theoretical and technical data. The methodology part includes the explanation of implemented methods in the present study. In present study, an attempt was made to design mucoadhesive buccal tablets containing alendronate, sodium alginate, ethyl cellulose and carbopol using as polymers. The tablets were prepared by direct compression method. The formulations were evaluated for hardness, thickness, friability, weight variation, drug content estimation, surface pH determination, swelling index, in vitro drug release. In vitro bioadhesive strength & in vitro release studies showed that formulation F11 showed optimum bioadhesive & exhibited optimum drug release 97.6% in 7hr. Kinetics results reveals that the F11 formulation follows zero order kinetics as correlation coefficient (r2) values are higher than that of first- order release kinetics.Optimized formula F11 show drug is released by non-Fickian diffusion mechanism. The stability studies of formulation F11 prepared mucoadhesive buccal tablets of alendronate were stable. Overall evaluations of the mucoadhesive of tablets show good mucoadhesive properties.

scholarly journals Novel insight into Potential Leishmanicidal Activities of Transdermal Patches of Nigella Sativa: Formulation Development, Physical Characterizations and In vitro In vivo Assays

2021 ◽  
Author(s):  
Barkat Ali Khan ◽  
Yasmin Asmat ◽  
Tariq Hayat Khan ◽  
Mughal Qayum ◽  
Sultan Muhammad Alshahrani ◽  
...  
Keyword(s):  
Drug Release ◽  
Nigella Sativa ◽  
Diffusion Mechanism ◽  
Fickian Diffusion ◽  
Formulation Development ◽  
Standard Drug ◽  
Drug Permeation ◽  
Transdermal Patches

Abstract Cutaneous Leishmaniasis (CL) is the most common type of Leishmaniasis which annually affects 1.5 million people worldwide. About 90% of cases are reported from countries such as Iran, Afghanistan, Pakistan, Iraq, and Saudi Arabia. The purpose of the present study was to fabricate transdermal patches of Nigella sativa (NS), characterize and to check its in vitro in vivo anti-Lieshmanial activity. Hydroalcohlic extract was analyzed for preliminary phytochemicals. Five formulations of transdermal patches (NS1, NS2, NS3, NS4 and NS5) were prepared by solvent evaporation method. The optimized formulation NS5 was characterized for FTIR, smoothness, brittleness, clarity, thickness, folding endurance, uniformity of weight, percent moisture content, in-vitro drug release, release kinetics, ex vivo drug permeation and in-vitro anti-Lieshmanial activity. In vivo anti-Lieshmanial activity was assessed in 30 patients (n = 30) suffering from CL. The FTIR studies showed no incompatibility among the active extract and polymers. In vitro anti-Lieshmanial assay was 194.6 ± 1.88 % as compared to standard drug (p > 0.05) and in vivo anti-Lieshmanial activity was 75 %. The drug release after 24 hours was 87.0 ± 0.94% in NS5 which showed non-Fickian diffusion mechanism while drug permeation across rabbit skin after 24 hours was up to 80.0 ± 0.91%. The results concluded that problems related to the medications parenterally used for Lieshmanial treatment can be managed by applying extract of Nigella sativa seeds in the form of transdermal patch.

Preparation and Characterization of Chelerythrine Nanoparticles Composed of Magnetic Multiwalled Carbon Nanotubes

2013 ◽  
Vol 788 ◽  
pp. 127-131 ◽  
Author(s):  
Yong Huang ◽  
Zhi De Zhou ◽  
Jin Tao Liang ◽  
Gui Yin Li
Keyword(s):  
Carbon Nanotubes ◽  
Drug Release ◽  
Multiwalled Carbon Nanotubes ◽  
Drug Carrier ◽  
Diffusion Mechanism ◽  
Fickian Diffusion ◽  
Adsorption Method ◽  
Multiwalled Carbon ◽  
Magnetic Multiwalled Carbon Nanotubes

In this study, chelerythrine nanoparticles composed of magnetic multiwalled carbon nanotubes (Fe3O4/MWNTs-CHE) were prepared by adsorption method with CHE as the model drug and Fe3O4/MWNTs nanocomposites as the drug carrier. Optimized nanoparticles were characterized by scanning electron microscopy (SEM), Zeta potential and in vitro drug release.The in vitro drug release profiles of Fe3O4/MWNTs-CHE nanoformulation exhibited a biphasic pattern with an initial fast release phase followed by a slower release phase. The CHE release profile from Fe3O4/MWNTs-CHE nanoparticles followed Korsmeyer-Peppas model with Fickian diffusion mechanism for drug release.

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