Exploring the Mysteries of Cannabis through Gas Chromatography

Mapping Intimacies ◽

10.5772/intechopen.94903 ◽

2020 ◽

Author(s):

María Teresa García-Valverde ◽

Verónica Sánchez de Medina ◽

Verónica Codesido ◽

Jesús Hidalgo-García ◽

Carlos Ferreiro-Vera

Keyword(s):

Gas Chromatography ◽

Quality Assurance ◽

Product Quality ◽

Health Effects ◽

Cannabis Sativa ◽

Sample Complexity ◽

Active Constituents ◽

Strong Interest ◽

Recent Advances ◽

Good Manufacturing Practices

In the last decades, cannabinoids, the active constituents of Cannabis sativa L., have been attracting a strong interest, regarding the health effects associated with the use of Cannabis and Cannabis-derived products. The progressive legalization of this species in several countries has prompted an increasing concern about the characterization and quantification of cannabinoids in diverse chemotypes of the plant, as well as the obtained final products. Therewith, Process and Product Quality Assurance (PPQA) becomes a mandatory practise to verify the Good Manufacturing Practices (GMP). Gas chromatography is one of the most used techniques in this sense due to its high attainable resolution. However, sample complexity and the thermal lability of cannabinoids hinder the analysis. In this chapter, a fully description of the recent advances in the Cannabis sativa L. analysis by gas chromatography will be presented, including different approaches that have come up to solve the obstacles encountered.

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Herbal products: The need of quality assurance and recent advances in quality control

Planta Medica ◽

10.1055/s-0034-1394542 ◽

2014 ◽

Vol 80 (16) ◽

Author(s):

S Alban

Keyword(s):

Quality Control ◽

Quality Assurance ◽

Herbal Products ◽

Recent Advances

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Method of analysis and quality-assurance practices by the U.S. Geological Survey Organic Geochemistry Research Group: Determination of geosmin and methylisoborneol in water using solid-phase microextraction and gas chromatography/mass spectrometry

Open-File Report ◽

10.3133/ofr02337 ◽

2002 ◽

Cited By ~ 3

Author(s):

L.R. Zimmerman ◽

A.C. Ziegler ◽

E.M. Thurman

Keyword(s):

Mass Spectrometry ◽

Gas Chromatography ◽

Quality Assurance ◽

Research Group ◽

Solid Phase Microextraction ◽

Solid Phase ◽

Organic Geochemistry ◽

Gas Chromatography Mass Spectrometry ◽

The U.S

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Analysis of terpenes in hemp (Cannabis sativa) by gas chromatography/mass spectrometry: Isomer identification analysis

Analysis of Cannabis - Comprehensive Analytical Chemistry ◽

10.1016/bs.coac.2020.04.013 ◽

2020 ◽

pp. 197-233

Author(s):

E. Michael Thurman

Keyword(s):

Mass Spectrometry ◽

Gas Chromatography ◽

Cannabis Sativa ◽

Gas Chromatography Mass Spectrometry ◽

Chromatography Mass Spectrometry ◽

Identification Analysis

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Role of Current Good Manufacturing Practices in Establishment of Quality Assurance for in-House Radiopharmaceuticals

Chemists’ Views of Imaging Centers ◽

10.1007/978-1-4757-9670-4_19 ◽

1995 ◽

pp. 157-168

Author(s):

Thomas E. Boothe ◽

Ali M. Emran

Keyword(s):

Quality Assurance ◽

Good Manufacturing Practices

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An improved gas chromatography screening method for doping substances using triple quadrupole mass spectrometry, with an emphasis on quality assurance

Biomedical Chromatography ◽

10.1002/bmc.2714 ◽

2012 ◽

Vol 26 (11) ◽

pp. 1416-1435 ◽

Cited By ~ 29

Author(s):

Nik De Brabanter ◽

Wim Van Gansbeke ◽

Lore Geldof ◽

Peter Van Eenoo

Keyword(s):

Mass Spectrometry ◽

Gas Chromatography ◽

Quality Assurance ◽

Screening Method ◽

Triple Quadrupole ◽

Quadrupole Mass ◽

Triple Quadrupole Mass Spectrometry ◽

Quadrupole Mass Spectrometry

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Donor platelet response and product quality assurance in plateletpheresis

Transfusion ◽

10.1046/j.1537-2995.1981.21381201794.x ◽

1981 ◽

Vol 21 (3) ◽

pp. 247-260 ◽

Cited By ~ 28

Author(s):

LC Lasky ◽

A Lin ◽

RA Kahn ◽

J McCullough

Keyword(s):

Quality Assurance ◽

Product Quality ◽

Platelet Response

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Towards Implementation of Process and Product Quality Assurance Process Area for Saudi Arabian Small and Medium Sized Software Development Organizations

IEEE Access ◽

10.1109/access.2018.2859249 ◽

2018 ◽

Vol 6 ◽

pp. 41643-41675 ◽

Cited By ~ 2

Author(s):

Ismail Keshta ◽

Mahmood Niazi ◽

Mohammad Alshayeb

Keyword(s):

Quality Assurance ◽

Software Development ◽

Product Quality ◽

Saudi Arabian ◽

Development Organizations ◽

Quality Assurance Process ◽

Assurance Process

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Cannabis sativa subsp. sativa’s pharmacological properties and health effects: A scoping review of current evidence

PLoS ONE ◽

10.1371/journal.pone.0245471 ◽

2021 ◽

Vol 16 (1) ◽

pp. e0245471

Author(s):

Xin Yi Lim ◽

Terence Yew Chin Tan ◽

Siti Hajar Muhd Rosli ◽

Muhammad Nor Farhan Sa’at ◽

Syazwani Sirdar Ali ◽

...

Keyword(s):

Health Effects ◽

Cannabis Sativa ◽

Journal Club ◽

Current Evidence ◽

Cochrane Library ◽

Future Research ◽

Pharmacological Properties ◽

Protective Effects ◽

Spontaneous Bowel Movement

Introduction Hemp (Cannabis sativa subsp. sativa), commonly used for industrial purposes, is now being consumed by the public for various health promoting effects. As popularity of hemp research and claims of beneficial effects rises, a systematic collection of current scientific evidence on hemp’s health effects and pharmacological properties is needed to guide future research, clinical, and policy decision making. Objective To provide an overview and identify the present landscape of hemp research topics, trends, and gaps. Methods A systematic search and analysis strategy according to the preferred reporting items for systematic review and meta-analysis-ScR (PRISMA-ScR) checklist on electronic databases including MEDLINE, OVID (OVFT, APC Journal Club, EBM Reviews), Cochrane Library Central and Clinicaltrials.gov was conducted to include and analyse hemp research articles from 2009 to 2019. Results 65 primary articles (18 clinical, 47 pre-clinical) were reviewed. Several randomised controlled trials showed hempseed pills (in Traditional Chinese Medicine formulation MaZiRenWan) improving spontaneous bowel movement in functional constipation. There was also evidence suggesting benefits in cannabis dependence, epilepsy, and anxiety disorders. Pre-clinically, hemp derivatives showed potential anti-oxidative, anti-hypertensive, anti-inflammatory, anti-diabetic, anti-neuroinflammatory, anti-arthritic, anti-acne, and anti-microbial activities. Renal protective effects and estrogenic properties were also exhibited in vitro. Conclusion Current evidence on hemp-specific interventions are still preliminary, with limited high quality clinical evidence for any specific therapeutic indication. This is mainly due to the wide variation in test item formulation, as the multiple variants of this plant differ in their phytochemical and bioactive compounds. Future empirical research should focus on standardising the hemp plant for pharmaceutical use, and uniformity in experimental designs to strengthen the premise of using hemp in medicine.

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