scholarly journals Salivary Gland Radio-Protection, Regeneration and Repair: Innovative Strategies

2021 ◽  
Author(s):  
Ziyad S. Haidar

Saliva has a critical role in the maintenance of oral, dental and general health and well-being. Alteration(s) in the amount/quantity and/or quality of secreted saliva may induce the development of several oro-dental variations, thereby negatively-impacting overall quality of life. Diverse factors may affect the process of saliva production and quantity/quality of secretion, including medications, systemic or local pathologies and/or reversible/irreversible damage. Indeed, chemo- and/or radio-therapy, particularly, in cases of head and neck cancer, for example, are well-documented to induce serious damage and dysfunction to the radio-sensitive salivary gland tissue, resulting in hypo-salivation, xerostomia (dry mouth) as well as numerous other adverse intra−/extra-oral, medical and quality-of-life issues. Although a single governing mechanism of radiation-induced salivary gland tissue damage and dysfunction has not been yet elucidated, the potential for a synergy in radio-protection (mainly, and possible -reparation) via a combinatorial approach of mechanistically distinct strategies, has been suggested and explored over the years. This is, undoubtfully, in parallel to the ongoing efforts in improving the precision, safety and efficacy of radiotherapy protocols/outcomes, as well as in developing new technological and pharmaceutical alternatives, topics covered in this chapter.

Author(s):  
Daniel T. L. Shek

AbstractCOVID-19 has severely affected the world since December 2020. Because of its sudden onset and highly contagious nature, the world has responded in a “crisis management” manner. With effective vaccines almost available, it is appropriate at this time to have some reflections about COVID-19 in relation to the quality of life issues. In this paper, we highlight twelve issues for reflection, which can help us better prepared for future pandemics. These include: digital divide, health inequality, gender inequality, economic disadvantage, family well-being, impact on holistic well-being, economic development versus saving lives, consumption versus environmental protection, individual rights versus collective rights, international collaboration versus conflict, prevention of negative well-being, and promotion of positive well-being.


Author(s):  
David Chadwick

ABSTRACT:In the treatment of the patient with epilepsy not only seizure control but quality of life issues are important aspects of management. Aspects that have an impact on the quality of life include seizure frequency and severity, social functioning, psychological well-being, disease specific measures, and general health status.


Author(s):  
Ana Raquel Ortega ◽  
Encarnación Ramírez ◽  
Alberto Chamorro

Background. Research has shown that happiness and well-being play a critical role in the health of the elderly. Therefore programs based on positive psychology include any of these variables to improve their quality of life by preventing and reducing the occurrence of emotional disorders. Objectives. Prove if an intervention based on Autobiographical Memory, Forgiveness, Gratitude and Sense of Humor will increase the quality of life in institutionalized elderly. Method. A quasi-experimental design with pre and post intervention measures were used. Participants. Twenty institutionalized people aged 65 years. Instruments. Measures were taken for depression, anxiety, happiness, life satisfaction, autobiographical memory and cognitive impairment by administering questionnaires. Procedure. After obtained informed consent, questionnaires were administered in an individual interview and the purpose of the intervention was explained. The duration of the program was eleven weeks and once completed, were reevaluated participants. Results. The intervention has been effective in producing an increase in the welfare of the elderly. Conclusions. The proposed intervention is revealed as one effective new tool easy to use and inexpensive to allow to improve the quality of life and emotional disorders of the elderly.


2020 ◽  
Vol 11 ◽  
pp. 204062072095500
Author(s):  
Pushpendra Goswami ◽  
Esther N. Oliva ◽  
Tatyana Ionova ◽  
Roger Else ◽  
Jonathan Kell ◽  
...  

Background: Our aim was to identify health-related quality-of-life (HRQoL) issues and symptoms in patients with haematological malignancies (HMs) and develop a conceptual framework to reflect the inter-relation between them. Methods: A total of 129 patients with HMs were interviewed in a UK multicentre qualitative study. All interviews were audio recorded, transcribed and analysed using NVivo-11. Results: Overall, 34 issues were reported by patients and were grouped into two parts: quality of life (QoL) and symptoms. The most prevalent HRQoL issues were: eating and drinking habits; social life; physical activity; sleep; and psychological well-being. Furthermore, most prevalent disease-related symptoms were: tiredness; feeling unwell; breathlessness; lack of energy; and back pain. The most prevalent treatment side effects were: tiredness; feeling sick; disturbance in sense of taste; and breathlessness. Conclusions: Both HMs and their treatments have a significant impact on patients’ HRQoL, in particular on issues such as job-role change, body image and impact on finances.


2007 ◽  
Vol 21 (4) ◽  
pp. 375-379 ◽  
Author(s):  
Sílvio Kenji Hirota ◽  
Sibele Sarti Penha ◽  
Carlos Neutzling Lehn ◽  
Norberto Nobuo Sugaya ◽  
Dante Antônio Migliari

This study was aimed at assessing the quality of life in patients submitted to surgical treatment for minor salivary gland neoplasms (MSGN). Twelve patients (10 women and 2 men, mean age: 49.4 years) with histopathologic diagnosis of pleomorphic adenoma (PA, 3 cases), polymorphous low-grade adenocarcinoma (PLGA, 2 cases), cystic adenoid carcinoma (CAC, 4 cases), and muco-epidermoid carcinoma (MEC, 3 cases) were evaluated. All of them were treated by surgical excision; patients with CAC received radiotherapy as well. The patients’ quality of life was evaluated through a self-administered questionnaire concerning their physical well-being, emotional status, normal daily activities, and family relationships. The results showed that patients with MEC - the youngest among all patients - reported a significantly greater worsening of their physical well-being and emotional status after treatment as compared with patients treated for PA (P < 0.05), and also of their functional activities as compared with those treated for PA and PLGA (P < 0.05). In conclusion, age of development of the neoplasm and type of disease produce more impact on patients’ quality of life than does the therapy’s degree of aggression.


2002 ◽  
Vol 116 (S28) ◽  
pp. 7-14 ◽  
Author(s):  
Sunil N. Dutt ◽  
Ann-Louise McDermott ◽  
Anwen Jelbert ◽  
Andrew P. Reid ◽  
David W. Proops

The Birmingham osseointegration programme began in 1988 and during the following 10 years there were a total of 351 bone-anchored hearing aid (BAHA) implantees. In the summer of 2000, a postal questionnaire study was undertaken to establish the impact of the bone-anchored hearing aid on all aspects of patients’ lives.We used the Glasgow benefit inventory (GBI), which is a subjective patient orientated post-interventional questionnaire especially developed to evaluate any otorhinolaryngological surgery and therapy. It is maximally sensitive to any change in health status brought about by a specific event: in this case the provision of a BAHA.A total of 312 bone-anchored hearing aid patients, who had used their aids for a minimum period of six months, were sent GBI questionnaires. Two hundred and twenty-seven questionnaires were returned and utilized in the study. The results revealed that the use of a bone-anchored hearing aid significantly enhanced general well being (patient benefit), improved the patient’s state of health (quality of life) and finally was considered a success by patients and their families.


1993 ◽  
Vol 59 (6) ◽  
pp. 499-512 ◽  
Author(s):  
Ruth E. Dennis ◽  
Wes Williams ◽  
Michael F. Giangreco ◽  
Chigee J. Cloninger

Quality of life has become a dominant theme in planning and evaluating services for people with disabilities. This article reviews definitions of quality of life, explores the concept from the perspective of the optimal theory of personal well-being, and surveys the research on the concept and its implications for planning and evaluating services. This article explores the subjective nature of life quality, particularly for people with disabilities, and relates the concept to both cultural norms and universal human values and needs. Each person experiences life, and disability, in unique ways. Practitioners need to consider quality-of-life issues as a context in planning and evaluating quality services.


Author(s):  
Dace Stiegele ◽  
Mirdza Paipare

In recent decades, quality of life issues and research have been increasingly focused on seeing a direct link between indicators of subjective well-being and economic growth. In Latvia, the issue of subjective well-being has also been raised in recent years in population surveys, but there are no trends in emphasizing the importance of these indicators in the context of quality of life.In Latvia, education is included in the statistical data collection among the most important quality of life indicators. In Latvia, the level of life satisfaction decreases most rapidly at the age of 45-54.Purpose of the article: to research the components of quality of life in Europe and Latvia, identify significant indicators for the mantaining of adult quality of life and view on education and subjective well-being in the context of assessment of quality of adults life.Method: the study carried out an content analysis of the data of Eurostat population quality of life surveys, the EU and the Republic of Latvia's official guidelines on quality of life and lifelong learning, as well as pedagogical and psychological literature and scientific articles on quality of life, subjective well-being and adult education issues. Results: according to survey data, adults with higher level of education experience higher level of participation in lifelong learning activities; the level of education affects the assessment of life satisfaction.  


Author(s):  
Ana Raquel Ortega ◽  
Encarnación Ramírez ◽  
Alberto Chamorro

Background. Research has shown that happiness and well-being play a critical role in the health of the elderly. Therefore programs based on positive psychology include any of these variables to improve their quality of life by preventing and reducing the occurrence of emotional disorders. Objectives. Prove if an intervention based on Autobiographical Memory, Forgiveness, Gratitude and Sense of Humor will increase the quality of life in institutionalized elderly. Method. A quasi-experimental design with pre and post intervention measures were used. Participants. Twenty institutionalized people aged 65 years. Instruments. Measures were taken for depression, anxiety, happiness, life satisfaction, autobiographical memory and cognitive impairment by administering questionnaires. Procedure. After obtained informed consent, questionnaires were administered in an individual interview and the purpose of the intervention was explained. The duration of the program was eleven weeks and once completed, were reevaluated participants. Results. The intervention has been effective in producing an increase in the welfare of the elderly. Conclusions. The proposed intervention is revealed as one effective new tool easy to use and inexpensive to allow to improve the quality of life and emotional disorders of the elderly.


GeroPsych ◽  
2019 ◽  
Vol 32 (3) ◽  
pp. 125-134
Author(s):  
Mechthild Niemann-Mirmehdi ◽  
Andreas Häusler ◽  
Paul Gellert ◽  
Johanna Nordheim

Abstract. To date, few studies have focused on perceived overprotection from the perspective of people with dementia (PwD). In the present examination, the association of perceived overprotection in PwD is examined as an autonomy-restricting factor and thus negative for their mental well-being. Cross-sectional data from the prospective DYADEM study of 82 patient/partner dyads (mean age = 74.26) were used to investigate the association between overprotection, perceived stress, depression, and quality of life (QoL). The analyses show that an overprotective contact style with PwD has a significant positive association with stress and depression, and has a negative association with QoL. The results emphasize the importance of avoiding an overprotective care style and supporting patient autonomy.


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