scholarly journals Herbal Medicine in Uterine Fibroid

2020 ◽  
Author(s):  
Zi-Lin Li ◽  
Tung-Yung Huang ◽  
Yih Ho ◽  
Ya-Jung Shih ◽  
Yi-Ru Chen ◽  
...  
Keyword(s):  
Uterine Fibroid ◽  
Antitumor Agents ◽  
Treatment Options ◽  
Uterine Fibroids ◽  
Herbal Medicines ◽  
Reproductive Age ◽  
Common Benign Tumor ◽  
Life Issues ◽  
Clinically Significant

Uterine fibroids, also known as uterine leiomyoma is the most common benign tumor of the uterus found in women of reproductive age. Uterine fibroids are the cause of major quality-of-life issues for approximately 25% of all women who suffer from clinically significant symptoms of uterine fibroid. Despite the prevalence of fibroid, currently, there are no effective treatment options for fibroid. The lack of understanding of the etiology of fibroid contributes to the scarcity of medical therapies available. Sex steroid hormones, dysregulation of cell signaling pathways, miRNA expression, and cytogenetic abnormalities may all implicate in fibroid etiology. Several herbal medicines have been used as anti-inflammation and antitumor agents. All of them have a common capability to inhibit expression of pro-inflammatory cytokines, proliferative genes, and pro-angiogenetic genes. Exploring herbal medicines as remedies lighten the hope of treatment. In the current review article, we discuss signal transduction pathways activated herbal medicines. We also address the possibility of using herbal medicines for uterine fibroid treatment.

scholarly journals The Rising Phoenix-Progesterone as the Main Target of the Medical Therapy for Leiomyoma

2017 ◽  
Vol 2017 ◽  
pp. 1-8 ◽  
Author(s):  
H. H. Chill ◽  
M. Safrai ◽  
A. Reuveni Salzman ◽  
A. Shushan
Keyword(s):  
Therapeutic Option ◽  
Treatment Options ◽  
Uterine Fibroids ◽  
Term Treatment ◽  
Reproductive Age ◽  
Surgical Approaches ◽  
Common Benign Tumor ◽  
Long Term Treatment ◽  
Suitable Treatment

Leiomyomas, also known as uterine fibroids, are a common benign tumor in women of reproductive age. These lesions disrupt the function of the uterus causing menorrhagia and pelvic pressure as well as reproductive disorders. These women pose a true challenge for clinicians in the attempt of choosing the suitable treatment for each patient. Patient’s age, interest in fertility preservation, and leiomyoma location and size are all factors to be taken into account when deciding upon the preferable therapeutic option. For the past few decades, surgical treatment was the only reliable long-term treatment available. A variety of surgical approaches have been developed over the years but these developments have come at the expense of other treatment options. The classical medical treatment includes gonadotropin-releasing hormone (GnRH) agonists and antagonists. These agents are well known for their limited clinical effect as well as their broad spectrum of side effects, inspiring a need for new pharmacological treatments. In recent years, promising results have been reported with the use of selective progesterone receptor modulators (SPRM). Long-term clinical trials have shown a reduction in bleeding and shrinkage of leiomyoma mass. These results instill hope for women suffering from symptomatic leiomyomas seeking an effective, long-term medical option for their condition.

scholarly journals Peranan Resveratrol terhadap Progresivitas Uterine Fibroid

2021 ◽  
Vol 2 (2) ◽  
pp. 102-109
Author(s):  
Made Indira Dianti Sanjiwani ◽  
I Made Widianantara
Keyword(s):  
Uterine Fibroid ◽  
Genetic Factors ◽  
Uterine Fibroids ◽  
Reproductive Age ◽  
Women Of Reproductive Age ◽  
Matrix Deposition ◽  
Grape Skins ◽  
Extracellular Matrix Deposition ◽  
Over 40 Years

Uterine fibroids or leiomyomas are benign neoplasms that occur in the uterus and still become a health problem among women of reproductive age. Predominantly, uterine fibroids are found at productive age but some cases are found after menopause. Based on previous studies, there were 145 cases of uterine fibroids in 2014 and 69.7% were found in women over 40 years. Patients with uterine fibroids show a decreased quality of life with symptoms such as heavy uterine bleeding, pelvic pain, and loss of pregnancy. The pathogenesis of uterine fibroids is still unknown, but genetic factors, cytokines, growth factors, and steroid hormones are weak and play an important role in the development of uterine fibroids. Several studies have shown the effect of resveratrol that can be obtained from grape skins. Resveratrol can reduce extracellular matrix deposition and uterine fibroid cell proliferation. Looking at the induced events then resveratrol is effective in preventing the progression of uterine fibroids.

scholarly journals STUDY TO COMPARE THE EFFICACY AND SAFETY OF ULIPRISTAL ACETATE AND MIFEPRISTONE AS MEDICAL TREATMENT OF UTERINE FIBROID.

2019 ◽  
Vol 3 (9) ◽  
Author(s):  
Dr. Sushmita Prasad ◽  
Dr. Subhashree Sethi
Keyword(s):  
Blood Loss ◽  
Uterine Fibroid ◽  
Obstructive Uropathy ◽  
Treatment Options ◽  
Uterine Fibroids ◽  
Pelvic Mass ◽  
Reproductive Age ◽  
Ulipristal Acetate ◽  
Medical College ◽  
Uterine Tumors

Uterine fibroids are one of the most common benign uterine tumors seen in females of reproductive age group. They either may be completely asymptomatic (diagnosed incidentally while doing ultrasound for some other reason) or may present as menorrhagia, lower abdominal or back pain, pelvic mass, obstructive uropathy, anemia secondary to blood loss and infertility. The management of uterine fibroids depends upon factors like possibility of pregnancy in future, whether preservation of uterus is desirable, severity and characteristics of symptoms. Various treatment options include observation and follow up, medical management (Mifepristone or Ulipristal acetate), uterine fibroid embolisation and hysterectomy. This study was done to know the effect of ulipristal acetate and mifepristone on Menstrual blood Loss, Dysmenorrhea, Uterine size & fibroid size. This was a comparative study done in 160 patients attending outpatient department of Obstetrics and Gynaecology of Patna Medical College and Hospital (PMCH). Treatment of symptomatic fibroids by Mifepristone as well as Ulipristal acetate was associated with reduction in fibroid size, reduced blood loss and decreased pain. We conclude from this study that both these drugs can be used for treatment of symptomatic fibroids Keywords:  Uterine Fibroid, Ulipristal Acetate, Mifepristone

scholarly journals Updated Costs of Uterine Fibroid Treatments Including Focused Ultrasound Surgery

2018 ◽  
Author(s):  
Bijan J. Borah ◽  
Elizabeth A. Stewart
Keyword(s):  
Magnetic Resonance ◽  
Focused Ultrasound ◽  
Treatment Options ◽  
Uterine Fibroids ◽  
Reproductive Age ◽  
Invasive Treatment ◽  
Ultrasound Surgery ◽  
Non Invasive ◽  
Focused Ultrasound Surgery ◽  
Reproductive Age Women

Uterine leiomyomas (fibroids) affect 20–40% of reproductive age women and are the major indication for hysterectomy. Magnetic Resonance-guided Focused Ultrasound Surgery (MRgFUS) is a new, potentially disruptive, non-invasive and uterine-sparing treatment option that has been shown to yield similar or better clinical outcomes than other uterine-sparing interventions. However, the costs of MRgFUS and other minimally-invasive treatment options have not been studied using US practice data. This study attempts to fill this void. And since uterine fibroids are the first FDA-approved indication for MRgFUS treatment, this study may also have implications for other indications which are now investigational.

scholarly journals Concept of Granthi with reference to uterine fibroid: An Ayurveda review

2021 ◽  
Vol 9 (02) ◽  
Author(s):  
Jaya Umate ◽  
Soudamini Chaudhari
Keyword(s):  
Life Span ◽  
Uterine Fibroid ◽  
Uterine Fibroids ◽  
Modern Science ◽  
Reproductive Age ◽  
Significant Morbidity ◽  
Reproductive Life ◽  
Reproductive Life Span ◽  
Gynecological Disease ◽  
Reproductive Age Group

Uterine fibroids are the commonest benign tumor of the uterus and also the commonest benign solid tumor in the female. It can cause significant morbidity in women of a reproductive life span. The exact cause of uterine fibroid is unknown. Prevalence of uterine fibroid 5 -20 % of women in the reproductive age group. It can cause significant morbidity in women of a reproductive life span. Not all fibroids cause symptoms. 50% of women are asymptomatic. Fibroids mainly cause symptoms like menorrhagia, dysmenorrhea and cause pressure symptoms on adjacent viscera i. e. bladder, uterus, rectum which affects the everyday activities of women. In Ayurveda all gynecological disease explained under the term yonivyapad. It can be explained as the anatomical and functional abnormalities of the female reproductive system. In Ayurveda granthi can be correlated with the uterine fibroid. In modern science uterine fibroid treats medically, surgically. But it is challenging to establish a satisfactory conservatory medical treatment to date. so in Ayurveda the main purpose is the management of granthi by samprapti vighatan by use of medicine.

scholarly journals Aberrant expression and regulation of NR2F2 and CTNNB1 in uterine fibroids

Reproduction ◽  
2013 ◽  
Vol 146 (2) ◽  
pp. 91-102 ◽  
Author(s):  
Marina Zaitseva ◽  
Sarah J Holdsworth-Carson ◽  
Luke Waldrip ◽  
Julia Nevzorova ◽  
Luciano Martelotto ◽  
...  
Keyword(s):  
Uterine Fibroid ◽  
Molecular Mechanisms ◽  
Primary Cultures ◽  
Uterine Fibroids ◽  
Reproductive Age ◽  
Causal Role ◽  
Aberrant Expression ◽  
Regulatory Pathways ◽  
Shh Pathway ◽  
Common Benign Tumour

Uterine fibroids are the most common benign tumour afflicting women of reproductive age. Despite the large healthcare burden caused by fibroids, there is only limited understanding of the molecular mechanisms that drive fibroid pathophysiology. Although a large number of genes are differentially expressed in fibroids compared with myometrium, it is likely that most of these differences are a consequence of the fibroid presence and are not causal. The aim of this study was to investigate the expression and regulation of NR2F2 and CTNNB1 based on their potential causal role in uterine fibroid pathophysiology. We used real-time quantitative RT-PCR, western blotting and immunohistochemistry to describe the expression of NR2F2 and CTNNB1 in matched human uterine fibroid and myometrial tissues. Primary myometrial and fibroid smooth muscle cell cultures were treated with progesterone and/or retinoic acid (RA) and sonic hedgehog (SHH) conditioned media to investigate regulatory pathways for these proteins. We showed that NR2F2 and CTNNB1 are aberrantly expressed in fibroid tissue compared with matched myometrium, with strong blood vessel-specific localisation. Although the SHH pathway was shown to be active in myometrial and fibroid primary cultures, it did not regulateNR2F2orCTNNB1mRNA expression. However, progesterone and RA combined regulatedNR2F2mRNA, but notCTNNB1, in myometrial but not fibroid primary cultures. In conclusion, we demonstrate aberrant expression and regulation of NR2F2 and CTNNB1 in uterine fibroids compared with normal myometrium, consistent with the hypothesis that these factors may play a causal role uterine fibroid development.

scholarly journals Ultrasound assessment of the uterine wall after hysteroscopic myomectomy of submucous uterine fibroids

2020 ◽  
Vol 19 (4) ◽  
pp. 5-21
Author(s):  
I.А. Esipova ◽  
◽  
L.M. Kappusheva ◽  
V.G. Breusenko ◽  
D.M. Lyafisheva ◽  
...  
Keyword(s):  
Uterine Fibroid ◽  
Surgical Navigation ◽  
Uterine Fibroids ◽  
Intraoperative Ultrasound ◽  
Precise Determination ◽  
The State ◽  
Reproductive Age ◽  
New Technique ◽  
Hysteroscopic Myomectomy ◽  
A New Technique

Objective. To study the state of the myometrium and the endometrium after hysteroscopic myomectomy of uterine fibroid using 2D/3D transvaginal echography in patients of reproductive age. Patients and methods. We examined 90 patients of reproductive age with submucous uterine fibroid, who underwent 117 one-, two- or three-step hysteroscopic resections performed with a new technique of transcervical myomectomy. 3D transvaginal echography was performed in all patients with target assessment of the fibroid type and the intended resection site, and also with subsequent assessment of its changes. Results. A new technique of fibroid resection with rigid loops was elaborated. New options for noninvasive 3D-US in preoperative diagnosis of uterine fibroids have been determined. Owing to 3D-US, the state of the endometrium, myometrium at the «resection site» were studied for the first time. Indications for one-, two- and tree-step resections have been specified. Conclusion. 3D transvaginal echography at the stage of planning hysteroscopic myomectomy allows not only a more precise determination of the fibroid type, assessment of its location and size, but also prediction of the length of operative intervention, the likelihood of multi-step resection and a risk of developing postoperative complications, as well as recommendation of other surgical treatments. Intraoperative ultrasound surgical navigation was introduced, which in combination with an appropriate resection technique permits to enhance the safety of surgical procedure. Depending on the echographic image of the endometrium and myometrium at the «resection site», specific recommendations have been formulated on management of the postoperative period that can permit to prevent the formation of synechiae and to determine precise terms of possible pregnancy occurrence. Key words: infertility, hysteroscopic myomectomy, resection site, uterine fibroid, reproductive age, submucosal fibroid, ultrasound examination, 3D-US

scholarly journals Title: Long-term health related quality of life following Uterine Fibroid Embolization 1 in a predominantly black African population: A retrospective Cohort study

2021 ◽  
Author(s):  
Marleen Temmerman ◽  
Timona Obura ◽  
Adelaide Lusambili ◽  
Michael Kioko
Keyword(s):  
Quality Of Life ◽  
Uterine Fibroid ◽  
Uterine Fibroids ◽  
Health Related Quality ◽  
Predominantly Black ◽  
Uterine Fibroid Embolization ◽  
Symptom Severity Score ◽  
Related Quality ◽  
Health Related

Abstract Background: Uterine Fibroid Embolization (UFE) is one of the effective options available for treatment of symptomatic uterine fibroids with documented improvement in the quality of life and reduction in symptoms. Most of the studies have demonstrated an improvement in the quality of life over a short to intermediate period. We carried out this study to assess the long-term quality of life following uterine fibroid embolization in a predominantly black population. There are no identified studies locally or in Africa addressing this issue whereas studies done elsewhere indicate a probable increased fibroid disease burden among black women. Methods: This was a retrospective single cohort study that recruited patients who had UFE between 2009-2014. Study participants were sampled consecutively, invited to the study and asked to fill an online general demographic tool and the UFS-QOL. Wilcoxon signed rank tests were done to test for statistical significance between HRQOL scores. Pearson correlation analysis was carried out to evaluate possible association between various independent factors and specific outcomes of interest such as quality of life and symptom severity score. Results: Data was obtained from 77 participants. The median duration after the initial UFE was eight years. The median health related quality of life was 88.6 (62.9-98.3). This was statistically significant from baseline median scores of similar studies. The median symptom severity score decreased from a baseline score of 54.7 (43.8-65.6) to 21.9 (6.3-42.2). This decrease was statistically significant (p-value <0.001). Twenty-four participants (31.1%) reported follow up fibroid treatments after the initial UFE procedure. Eleven participants (14.3%) reported major repeat procedures (myomectomy, hysterectomy and UFE) .Seventeen participants (22%) reported a pregnancy after the UFE procedure with ten participants (13 %) reporting to have had children after the UFE procedure. Conclusion: UFE results in clinically sustained improvement in health related quality of life and symptom control among patients with uterine fibroids.

scholarly journals Contemporary concepts of uterine fibroids’ pathogenesis

2019 ◽  
Vol 10 (1) ◽  
pp. 91-99
Author(s):  
Anna N. Taits ◽  
Nikolai N. Ruhljada ◽  
Valeriy I. Matukhin ◽  
Aleksandra D. Somova ◽  
Kristina A. Dudova
Keyword(s):  
Growth Factors ◽  
Growth Factor ◽  
Epidermal Growth Factor ◽  
Transforming Growth Factor ◽  
Uterine Fibroids ◽  
Transforming Growth Factor Β ◽  
Reproductive Age ◽  
Heparin Binding ◽  
Common Benign Tumor ◽  
Epidermal Growth

Uterine myoma is the most common benign tumor among women which affects mainly those of reproductive age. Moreover, the frequency of emergence of this pathology in population is growing while the age of patients is steadily decreasing. Despite the enormous prevalence of this disease, its pathogenesis has not been studied properly. This article is concerned with an analysis of publications devoted to the study of the mechanisms of growth and development of uterine fibroids, it provides some data on the role of various factors in its extension. The article concerns the most popular concepts of the pathogenesis of this disease according to which the illness may be caused by increased levels of sex hormones (estrogens and progestins), enhanced expression of their receptors, impaired apoptosis, the effect of growth factors (e. g. epidermal growth factor, heparin-binding epidermal growth factor, acid and basic fibroblast growth factors, vascular endothelial growth factor, insulin-like growth factor, platelet-derived growth factor, transforming growth factor-β, activin, myostatin), abnormal deposition extracellular matrix, genetic (chromosomal aberration and various MED12 gene defect) and epigenetic mechanisms (such as action microRNA), circulatory disorders and impairment of cell differentiation from a population of accessory stem cells. However, it is noted that the pathogenesis of this pathology requires further detailed study, as the understanding of the processes leading to its development could greatly contribute to the improvement of the tactics of treatment and possibly allow to elaborate some preventive measures to avert the development of fibroids.

scholarly journals UNDERSTANDING FIBROIDS IN LIGHT OF AYURVEDA

2020 ◽  
pp. 95-99
Author(s):  
Mary Blossom CJ ◽  
Giby Thomas ◽  
Jyothi PK
Keyword(s):  
Social Life ◽  
Lifestyle Modification ◽  
Uterine Fibroids ◽  
Reproductive Age ◽  
Treatment Protocols ◽  
Wide Range ◽  
Unique Approach ◽  
Current Article ◽  
Modern Era

The changing lifestyle and dietary pattern has given way to many gynecological problems in females. Uterine fibroids are one of leading concerns for women in reproductive age. Though uterine fibroids are non- cancerous in character; they exhibit a wide range of symptoms like dysmenorrhea, menorrhagia, metrorrhagia, low backache etc. It significantly hampers the general health and quality of life in women causing great mental agony. Contemporary treatment protocols include hormonal therapy, hysterectomy, myomectomy and uterine artery embolization. Reluctance to undergo prolonged hormone therapy, the fear of surgery brings more and more patient to Ayurveda. Hence more systematic studies in conservative management in these areas of Stree Roga are need of the hour. Ayurveda classics mention various pathological conditions that have features similar to fibroids. Owing to its muscular origin, with slow growth may be better compared to Granthi in Garbhasya. In the modern era of busy lifestyle, intake of junk food, lack of exercise etc had lead to Agnivaishamya and Ama formation. This in turn vitiates Doshas like Kapha and Vata and Dushyas like Rasa, Raktha, Mamsa, Medas and Arthava resulting in Dhatwagnimandya leading to formation of Garbhasayagranthi. The treatment approach is directed towards reducing size of fibroids using Ushna, Tiskhna, Lekhana Dravyas along with management of symptoms. The inevitable roles of Vata in Yoniroga is also taken into account in its management. Combining different treatment aspects of Granthi and Yoni Roga Chitksa, a unique approach towards the management of its varied presentations added on with lifestyle modification can contribute to healthy social life. The current article focuses and explores potentials of Ayurveda in different aspects of uterine fibroid.

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