scholarly journals Hypothalamic-Pituitary-Adrenal (HPA) Axis and Chronic Fatigue Syndrome in Older Adults: The Rehabilitation Perspectives

2020 ◽  
Author(s):  
Frank Ho-Yin Lai ◽  
Maria Uscinska ◽  
Elaine Wai-hung Yan
Keyword(s):  
Older Adults ◽  
Chronic Fatigue Syndrome ◽  
Hpa Axis ◽  
Chronic Fatigue ◽  
Hypothalamic Pituitary Adrenal ◽  
Fatigue Syndrome

scholarly journals A Review of Hypothalamic-Pituitary-Adrenal Axis Function in Chronic Fatigue Syndrome

2013 ◽  
Vol 2013 ◽  
pp. 1-8 ◽  
Author(s):  
Cara Tomas ◽  
Julia Newton ◽  
Stuart Watson
Keyword(s):  
Chronic Fatigue Syndrome ◽  
Hpa Axis ◽  
Treatment Strategies ◽  
Chronic Fatigue ◽  
Interindividual Variation ◽  
Genetic Profile ◽  
Hypothalamic Pituitary Adrenal ◽  
Fatigue Syndrome ◽  
Novel Treatment Strategies ◽  
The Impact

Hypothalamic-pituitary-adrenal (HPA) axis dysfunction has been found in a high proportion of chronic fatigue syndrome (CFS) patients and includes enhanced corticosteroid-induced negative feedback, basal hypocortisolism, attenuated diurnal variation, and a reduced responsivity to challenge. A putative causal role for genetic profile, childhood trauma, and oxidative stress has been considered. In addition, the impact of gender is demonstrated by the increased frequency of HPA axis dysregulation in females. Despite the temporal relationship, it is not yet established whether the endocrine dysregulation is causal, consequent, or an epiphenomenon of the disorder. Nonetheless, given the interindividual variation in the effectiveness of existing biological and psychological treatments, the need for novel treatment strategies such as those which target the HPA axis is clear.

Chronic Fatigue Syndrome: Circadian Rhythm and Hypothalamic-Pituitary-Adrenal (HPA) Axis Impairment

2001 ◽  
Vol 14 (1) ◽  
pp. 11-15 ◽  
Author(s):  
D. Racciatti ◽  
M. T. Guagnano ◽  
J. Vecchiet ◽  
P. L. De Remigis ◽  
E. Pizzigallo ◽  
...  
Keyword(s):  
Circadian Rhythm ◽  
Chronic Fatigue Syndrome ◽  
Hpa Axis ◽  
Chronic Fatigue ◽  
Hypothalamic Pituitary Adrenal ◽  
Fatigue Syndrome

Increased HDAC in association with decreased plasma cortisol in older adults with chronic fatigue syndrome

2011 ◽  
Vol 25 (8) ◽  
pp. 1544-1547 ◽  
Author(s):  
Leonard Jason ◽  
Matthew Sorenson ◽  
Kebba Sebally ◽  
Dalal Alkazemi ◽  
Athena Lerch ◽  
...  
Keyword(s):  
Older Adults ◽  
Chronic Fatigue Syndrome ◽  
Plasma Cortisol ◽  
Chronic Fatigue ◽  
Fatigue Syndrome

scholarly journals Persistent burnout theory of chronic fatigue syndrome

2015 ◽  
Author(s):  
David Jameson
Keyword(s):  
Chronic Fatigue Syndrome ◽  
Chronic Stress ◽  
Hpa Axis ◽  
Chronic Fatigue ◽  
Stress System ◽  
Occupational Burnout ◽  
Fatigue Syndrome ◽  
Growing Body ◽  
Physiological Abnormalities ◽  
Behavioural Factors

There is no agreement on the etiology of chronic fatigue syndrome (CFS), and the main theories (behavioural and viral/immune) do not satisfactorily explain all findings. A growing body of evidence shows that CFS appears to be a dysfunction of the stress system—and the hypothalamic–pituitary–adrenal (HPA) axis in particular—as a result of chronic stress. CFS shares many similarities to occupational burnout, including similar symptoms, physiological abnormalities and triggers. After a review of the available evidence, I hypothesize that CFS is a state of persistent burnout that remains after the initial stressors have been removed. This persistence may be due to a combination of a dysregulation of the HPA axis and behavioural factors.

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