scholarly journals Liver Assist Devices for Liver Failure

2020 ◽  
Author(s):  
Amrendra Kumar Mandal ◽  
Pavani Garlapati ◽  
Benjamin Tiongson ◽  
Vijay Gayam
Keyword(s):  
Liver Failure ◽  
Assist Devices ◽  
Liver Assist Devices

Acute-on-chronic liver failure: extracorporeal liver assist devices

2011 ◽  
Vol 17 (2) ◽  
pp. 195-203 ◽  
Author(s):  
Tarek I Hassanein ◽  
Robert R Schade ◽  
Iryna S Hepburn
Keyword(s):  
Liver Failure ◽  
Chronic Liver ◽  
Chronic Liver Failure ◽  
Assist Devices ◽  
Liver Assist Devices

scholarly journals Therapeutic plasma exchange in children with acute liver failure (ALF): is it time for incorporation into the ALF armamentarium?

2021 ◽  
Author(s):  
Emma C. Alexander ◽  
Akash Deep
Keyword(s):  
Liver Failure ◽  
Acute Liver Failure ◽  
Plasma Exchange ◽  
Controlled Trial ◽  
High Volume ◽  
Systemic Circulation ◽  
Liver Support ◽  
Extracorporeal Liver Support ◽  
Randomised Controlled ◽  
Liver Assist Devices

AbstractPaediatric acute liver failure (PALF) is a rare but devastating condition with high mortality. An exaggerated inflammatory response is now recognised as pivotal in the pathogenesis and prognosis of ALF, with cytokine spill from the liver to systemic circulation implicated in development of multi-organ failure associated with ALF. With advances in medical management, especially critical care, there is an increasing trend towards spontaneous liver regeneration, averting the need for emergency liver transplantation or providing stability to the patient awaiting a graft. Hence, research is ongoing for therapies, including extracorporeal liver support devices, that can bridge patients to transplant or spontaneous liver recovery. Considering the immune-related pathogenesis and inflammatory phenotype of ALF, plasma exchange serves as an ideal liver assist device as it performs both the excretory and synthetic functions of the liver and, in addition, works as an immunomodulatory therapy by suppressing the early innate immune response in ALF. After a recent randomised controlled trial in adults demonstrated a beneficial effect of high-volume plasma exchange on clinical outcomes, this therapy was incorporated in European Association for the Study of Liver (EASL) recommendations for managing adult patients with ALF, but no guidelines exist for PALF. In this review, we discuss rationale, timing, practicalities, and existing evidence regarding the use of plasma exchange as an immunomodulatory treatment in PALF. We discuss controversies in delivery of this therapy as an extracorporeal device, and practicalities of use of plasma exchange as a ‘hybrid’ therapy alongside other extracorporeal liver assist devices, before finally reviewing outstanding research questions for the future.

Enzyme-Based Hemoperfusion and Blood Treatment

1986 ◽  
Vol 9 (5) ◽  
pp. 331-334 ◽  
Author(s):  
N. Lotan ◽  
E. Grynspan ◽  
H. Grunfeld ◽  
G. Brunner ◽  
S. Sideman
Keyword(s):  
Mass Transfer ◽  
Liver Failure ◽  
Genetic Disease ◽  
The Body ◽  
Artificial Organs ◽  
Assist Devices ◽  
Transfer Characteristics ◽  
Normal Metabolism

Enzyme-based artificial organs are being developed as metabolic assist devices. These are required when normal metabolism is impaired, or when the body is overloaded by undesired metabolites or toxins. The implementations of this approach for treating a genetic disease, and for metabolic support in liver failure are envisaged. The kinetic aspects and mass transfer characteristics of bioreactors for these systems are considered in detail.

Extracorporeal Tissue Engineered Liver-Assist Devices

2000 ◽  
Vol 2 (1) ◽  
pp. 607-632 ◽  
Author(s):  
Emmanouhl S. Tzanakakis ◽  
Donavon J. Hess ◽  
Timothy D. Sielaff ◽  
Wei-Shou Hu
Keyword(s):  
Assist Devices ◽  
Liver Assist Devices

Bioengineering of liver assist devices

2002 ◽  
Vol 9 (6) ◽  
pp. 686-696 ◽  
Author(s):  
Arno W. Tilles ◽  
Fran�ois Berthiaume ◽  
Martin L. Yarmush ◽  
Ronald G. Tompkins ◽  
Mehmet Toner
Keyword(s):  
Assist Devices ◽  
Liver Assist Devices
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