scholarly journals Research Progress of DNA Methylation in Thyroid Cancer

2020 ◽  
Author(s):  
Zhu Gaohong ◽  
Xie Lijun
Keyword(s):  
Dna Methylation ◽  
Thyroid Cancer ◽  
Research Progress

Research progress in predicting DNA methylation modifications and the relation with human diseases

2021 ◽  
Vol 28 ◽  
Author(s):  
Chunyan Ao ◽  
Lin Gao ◽  
Liang Yu
Keyword(s):  
Dna Methylation ◽  
Eukaryotic Cell ◽  
Machine Learning Algorithms ◽  
Research Progress ◽  
Epigenetic Mechanisms ◽  
Biological Processes ◽  
Prediction Tools ◽  
Transformation Mechanisms ◽  
The Relationship ◽  
Treatment And Diagnosis

: DNA methylation is an important mode of regulation in epigenetic mechanisms, and it is one of the research foci in the field of epigenetics. DNA methylation modification affects a series of biological processes, such as eukaryotic cell growth, differentiation and transformation mechanisms, by regulating gene expression. In this review, we systematically summarized the DNA methylation databases, prediction tools for DNA methylation modification, machine learning algorithms for predicting DNA methylation modification, and the relationship between DNA methylation modification and diseases such as hypertension, Alzheimer's disease, diabetic nephropathy, and cancer. An in-depth understanding of DNA methylation mechanisms can promote accurate prediction of DNA methylation modifications and the treatment and diagnosis of related diseases.

scholarly journals Research progress and prospect of DNA methylation in perennial woody plants

2020 ◽  
Vol 50 (2) ◽  
pp. 154-166
Author(s):  
LianZheng LI ◽  
YuanYuan FANG ◽  
LiangChen YAO ◽  
DeQiang ZHANG ◽  
Liang XIAO ◽  
...  
Keyword(s):  
Dna Methylation ◽  
Woody Plants ◽  
Research Progress

scholarly journals DNA methylation in thyroid cancer

2019 ◽  
Vol 26 (7) ◽  
pp. R415-R439 ◽  
Author(s):  
Carles Zafon ◽  
Joan Gil ◽  
Beatriz Pérez-González ◽  
Mireia Jordà
Keyword(s):  
Dna Methylation ◽  
Thyroid Cancer ◽  
Cancer Genomics ◽  
Therapeutic Potential ◽  
Current Knowledge ◽  
Genetic Alterations ◽  
Epigenetic Mechanism ◽  
Aberrant Methylation ◽  
Technological Advances ◽  
Molecular Landscape

In recent years, cancer genomics has provided new insights into genetic alterations and signaling pathways involved in thyroid cancer. However, the picture of the molecular landscape is not yet complete. DNA methylation, the most widely studied epigenetic mechanism, is altered in thyroid cancer. Recent technological advances have allowed the identification of novel differentially methylated regions, methylation signatures and potential biomarkers. However, despite recent progress in cataloging methylation alterations in thyroid cancer, many questions remain unanswered. The aim of this review is to comprehensively examine the current knowledge on DNA methylation in thyroid cancer and discuss its potential clinical applications. After providing a general overview of DNA methylation and its dysregulation in cancer, we carefully describe the aberrant methylation changes in thyroid cancer and relate them to methylation patterns, global hypomethylation and gene-specific alterations. We hope this review helps to accelerate the use of the diagnostic, prognostic and therapeutic potential of DNA methylation for the benefit of thyroid cancer patients.

Genomic DNA methylation analysis revealed that BLNK is a key potential gene in the regulation of autophagy-related thyroid cancer progression

Genome ◽  
2021 ◽  
Author(s):  
Shengchi Zhang ◽  
Yongzhe Zheng ◽  
Guimin Zhang ◽  
Peng Lin ◽  
Wei Wang
Keyword(s):  
Dna Methylation ◽  
Thyroid Cancer ◽  
Cancer Progression ◽  
Protein Interactions ◽  
Methylation Status ◽  
Expression Change ◽  
Prognostic Analysis ◽  
Key Genes ◽  
New Perspective ◽  
The Relationship

The purpose of this study was to explore the relationship between autophagy and DNA methylation, and to identify key genes for autophagy-regulated thyroid cancer progression. We divided patients with thyroid cancer into high-autophagy score (AS) group and low-AS group based on their AS values. The results found that AS was associated with the distant metastasis of thyroid cancer, and adversely affected prognosis. Then, we screened 359 differently expressed genes (DEGs) with DNA methylation status consistent with gene expression change. Functional classification analysis demonstrated that the 359 DEGs consistent with DNA methylation status were significantly involved in adhesion, migration and differentiation of immune cells. To further screen the key genes in the autophagy-related thyroid cancer progression, we constructed a protein-protein interactions (PPI) network and performed prognostic analysis. B cell linker (BLNK) was identified as the key potential gene affecting autophagy-related thyroid cancer progression. Finally, we verified that BLNK promoted the proliferation of thyroid cancer cells, and BLNK expression was regulated by DNA methylation. Our research provides a new perspective for exploring the relationship between autophagy and DNA methylation during the progression of thyroid cancer, and provides a new target for the treatment of metastatic thyroid cancer.

Research progress on DNA methylation in hepatocellular carcinoma

2017 ◽  
Vol 6 (5) ◽  
pp. 981-998
Author(s):  
Yongchang Zheng ◽  
Xin Wang ◽  
Feihu Xie ◽  
Zhaoqi Gu ◽  
Li He ◽  
...  
Keyword(s):  
Hepatocellular Carcinoma ◽  
Dna Methylation ◽  
Research Progress

Global DNA methylation profile in medullary thyroid cancer patients

2018 ◽  
Vol 105 (1) ◽  
pp. 110-114 ◽  
Author(s):  
Lucieli Ceolin ◽  
Ana Paula Palauro Goularte ◽  
Carla Vaz Ferreira ◽  
Mírian Romitti ◽  
Ana Luiza Maia
Keyword(s):  
Dna Methylation ◽  
Thyroid Cancer ◽  
Cancer Patients ◽  
Medullary Thyroid Cancer ◽  
Methylation Profile ◽  
Global Dna Methylation ◽  
Medullary Thyroid ◽  
Dna Methylation Profile

DNA methylation alterations as therapeutic prospects in thyroid cancer

2018 ◽  
Vol 42 (4) ◽  
pp. 363-370 ◽  
Author(s):  
K. Zhang ◽  
C. Li ◽  
J. Liu ◽  
X. Tang ◽  
Z. Li
Keyword(s):  
Dna Methylation ◽  
Thyroid Cancer

scholarly journals The Roles of Epigenetics Regulation in Bone Metabolism and Osteoporosis

2021 ◽  
Vol 8 ◽  
Author(s):  
Fei Xu ◽  
Wenhui Li ◽  
Xiao Yang ◽  
Lixin Na ◽  
Linjun Chen ◽  
...  
Keyword(s):  
Dna Methylation ◽  
Histone Modification ◽  
Osteogenic Differentiation ◽  
Bone Metabolism ◽  
Bone Fragility ◽  
Research Progress ◽  
Epigenetic Mechanisms ◽  
Mineral Density ◽  
Transcriptional Regulatory ◽  
Non Coding Rnas

Osteoporosis is a metabolic disease characterized by decreased bone mineral density and the destruction of bone microstructure, which can lead to increased bone fragility and risk of fracture. In recent years, with the deepening of the research on the pathological mechanism of osteoporosis, the research on epigenetics has made significant progress. Epigenetics refers to changes in gene expression levels that are not caused by changes in gene sequences, mainly including DNA methylation, histone modification, and non-coding RNAs (lncRNA, microRNA, and circRNA). Epigenetics play mainly a post-transcriptional regulatory role and have important functions in the biological signal regulatory network. Studies have shown that epigenetic mechanisms are closely related to osteogenic differentiation, osteogenesis, bone remodeling and other bone metabolism-related processes. Abnormal epigenetic regulation can lead to a series of bone metabolism-related diseases, such as osteoporosis. Considering the important role of epigenetic mechanisms in the regulation of bone metabolism, we mainly review the research progress on epigenetic mechanisms (DNA methylation, histone modification, and non-coding RNAs) in the osteogenic differentiation and the pathogenesis of osteoporosis to provide a new direction for the treatment of bone metabolism-related diseases.

scholarly journals Epigenetic evidence of malignant carcinoma and skin melanoma neoplasms concomitantly in the thyroid

2021 ◽  
Author(s):  
Ali Al-Harake ◽  
Israa Dandache ◽  
Hiba Moukadem ◽  
Marwan Saliba ◽  
Jimmy Chahine ◽  
...  
Keyword(s):  
Dna Methylation ◽  
Thyroid Cancer ◽  
Total Thyroidectomy ◽  
Medullary Thyroid Cancer ◽  
Methylation Profile ◽  
Skin Melanoma ◽  
Medullary Thyroid ◽  
Dna Methylation Profile ◽  
Malignant Skin ◽  
Multiple Nodules

The study investigates the case of a total thyroidectomy, where after dissection multiple nodules showed two malignant patterns by immunohistochemistry. Molecular analysis based on DNA methylation profile was used to further inspect the origin of the coexisting neoplasms. We confirmed the presence of malignant skin melanoma involving medullary thyroid cancer.

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