scholarly journals Metabolic Syndrome: Impact of Dietary Therapy

2020 ◽  
Author(s):  
Suzanne Fouad Soliman
Keyword(s):  
Metabolic Syndrome ◽  
Dietary Therapy

scholarly journals GSH levels affect weight loss in individuals with metabolic syndrome and obesity following dietary therapy

2018 ◽  
Author(s):  
Nikolaos Goutzourelas ◽  
Marina Orfanou ◽  
Ioannis Charizanis ◽  
George Leon ◽  
Demetrios Spandidos ◽  
...  
Keyword(s):  
Metabolic Syndrome ◽  
Weight Loss ◽  
Dietary Therapy

scholarly journals Fatty acids and the metabolic syndrome

2005 ◽  
Vol 64 (1) ◽  
pp. 23-29 ◽  
Author(s):  
Helen M. Roche
Keyword(s):  
Insulin Resistance ◽  
Metabolic Syndrome ◽  
Fatty Acids ◽  
Health Effects ◽  
Aetiological Factor ◽  
Dietary Therapy ◽  
Adverse Health Effects ◽  
Adverse Health ◽  
The Metabolic Syndrome ◽  
The Impact

The metabolic syndrome is a very common condition, characterised by insulin resistance, dyslipidaemia, abdominal obesity and hypertension, that is associated with a high risk of type 2 diabetes mellitus (T2DM) and CVD. Obesity is a key aetiological factor in the development of the metabolic syndrome. In light of the increasing prevalence of obesity, there is a high requirement to reduce the impact of the adverse health effects associated with the metabolic syndrome. The aetiological role of nutrient-derived metabolic stressors, in particular fatty acids, in the development of obesity and the metabolic syndrome is explored. Also, the evidence that pro-inflammatory stressors may predispose to obesity-induced insulin resistance is reviewed. The present paper explores the concept that reducing the impact of metabolic and inflammatory stressors may reduce the adverse health effects of obesity and slow the progression towards the metabolic syndrome and T2DM. Evidence from human dietary intervention studies that have investigated the potential therapeutic effects of dietary fatty acid modification is explored. The present review highlights the requirement to take account of genetic background, within the context of nutrient regulation of gene expression and individual responsiveness to dietary therapy. This approach will further the understanding of the interaction between fatty acids in the pathogenesis and progression of the metabolic syndrome.

scholarly journals Possibilities of use of metformin for correction of endothelial dysfunction and adaptation reserves of an organism in patients with metabolic syndrome

2020 ◽  
Vol 27 (4) ◽  
pp. 458-467
Author(s):  
Aleksej A. Nizov ◽  
Ekaterina I. Suchkova ◽  
Aleksej I. Grivenko ◽  
Larisa V. Nikiforova
Keyword(s):  
Metabolic Syndrome ◽  
Endothelial Dysfunction ◽  
Clinical Laboratory ◽  
The Body ◽  
Dietary Therapy ◽  
Specific Adaptation ◽  
Laboratory Parameters ◽  
Endothelin 1 ◽  
Physical Exercises ◽  
Complex Therapy

Aim. To study possibilities of pharmaceutical correction of clinical laboratory parameters, of endothelial dysfunction and non-specific adaptation reserves in patients with metabolic syndrome (MS) through use of metformin. Materials and Methods. The three-month program involved 53 patients with MS rando-mized to two comparable groups. Patients of the control group were kept on individual low-calorie diet and practiced graduated exercises. Patients of the studied group, besides the mentioned program of modification of the lifestyle, took metformin. In all participants, anthropometric and clinical laboratory parameters were twice evaluated, total body composition, condition of vascular endothelium and non-specific adaptation reserves of an organism were analyzed. The extent of endothelial dysfunction was evaluated by the level of endothelin-1 and by parameters of photoplethysmographic examination, non-specific adaptation reserves by the method of analysis of the cardiac rhythm variability. Results. Metformin in complex with dietary therapy and physical exercises proved to be a safe medical drug for correction of components of MS and of endothelial dysfunction. Use of metformin in patients with MS in combination with dietary therapy and graduated physical exercises as compared to use of the program of modification of the lifestyle alone, leads to reduction in the body mass, waist circumference (in women) and of the total fat mass. Introduction of metformin into the program of complex therapy of patients with MS, provides more evident correction of the parameters of carbohydrate metabolism, reduction of endothelin-1 and stiffness index of the aortic wall, enhancement of parasympathetic regulation, than modification of the lifestyle alone. Conclusion. Use of metformin in the complex therapy of metabolic syndrome in comparison with the program of modification of the lifestyle, promotes a more significant reduction of the clinical laboratory parameters, of endothelial dysfunction and improves non-specific adaptation reserves of an organism.

scholarly journals The metabolic syndrome: the crossroads of diet and genetics

2005 ◽  
Vol 64 (3) ◽  
pp. 371-377 ◽  
Author(s):  
Helen M. Roche ◽  
Catherine Phillips ◽  
Michael J. Gibney
Keyword(s):  
Metabolic Syndrome ◽  
Clinical Characteristics ◽  
Regulation Of Gene Expression ◽  
Disease Process ◽  
Dietary Fatty Acids ◽  
Aetiological Factor ◽  
Dietary Therapy ◽  
Common Disease ◽  
The Metabolic Syndrome ◽  
Increased Risk

The metabolic syndrome is a very common disease associated with an increased risk of type 2 diabetes mellitus (T2DM) and CVD. The clinical characteristics of the metabolic syndrome include insulin resistance, dyslipidaemia, abdominal obesity and hypertension. The diverse clinical characteristics illustrate the complexity of the disease process, which involves several dysregulated metabolic pathways. Thus, multiple genetic targets must be involved in the pathogenesis and progression of the metabolic syndrome. Nevertheless, the human genome has not changed markedly in the last decade but the prevalence of the metabolic syndrome has increased exponentially, which illustrates the importance of gene–environmental interactions. There is good evidence that nutrition plays an important role in the development and progression of the metabolic syndrome. Indeed, obesity is a key aetiological factor in the development of the metabolic syndrome. Understanding the biological impact of gene–nutrient interactions will provide a key insight into the pathogenesis and progression of diet-related polygenic disorders, including the metabolic syndrome. The present paper will explore the interactions between genetic background and dietary exposure or nutritional therapy, focusing on the role of dietary fatty acids within the context of nutrient regulation of gene expression and individual responsiveness to dietary therapy. Only with a full understanding of gene–gene, gene–nutrient and gene–nutrient–environment interactions can the molecular basis of the metabolic syndrome be solved to minimise the adverse health effects of obesity and reduce the risk of the metabolic syndrome, and subsequent T2DM and CVD.

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