scholarly journals Recent Developments of Target-Based Benzimidazole Derivatives as Potential Anticancer Agents

2020 ◽  
Author(s):  
Nerella Sridhar Goud ◽  
Pardeep Kumar ◽  
Rose Dawn Bharath
Keyword(s):  
Anticancer Agents ◽  
Benzimidazole Derivatives ◽  
Recent Developments

Recent Progress of Benzimidazole Hybrids for Anticancer Potential

2020 ◽  
Vol 27 (35) ◽  
pp. 5970-6014 ◽  
Author(s):  
Md. Jawaid Akhtar ◽  
Mohammad Shahar Yar ◽  
Vinod Kumar Sharma ◽  
Ahsan Ahmed Khan ◽  
Zulphikar Ali ◽  
...  
Keyword(s):  
Anticancer Agents ◽  
Biological Activities ◽  
Alkylating Agents ◽  
American Chemical Society ◽  
Chemical Society ◽  
Benzimidazole Derivatives ◽  
Progressive Development ◽  
Anticancer Properties ◽  
Naturally Occurring ◽  
Nitrogenous Base

This review presents the detailed account of factors leading to cancer and design strategy for the synthesis of benzimidazole derivatives as anticancer agents. The recent survey for cancer treatment in Cancer facts and figures 2017 American Chemical Society has shown progressive development in fighting cancer. Researchers all over the world in both developed and developing countries are in a continuous effort to tackle this serious concern. Benzimidazole and its derivatives showed a broad range of biological activities due to their resemblance with naturally occurring nitrogenous base i.e. purine. The review discussed benzimidazole derivatives showing anticancer properties through a different mechanism viz. intercalation, alkylating agents, topoisomerases, DHFR enzymes, and tubulin inhibitors. Benzimidazole derivatives act through a different mechanism and the substituents reported from the earlier and recent research articles are prerequisites for the synthesis of targeted based benzimidazole derivatives as anticancer agents. The review focuses on an easy comparison of the substituent essential for potency and selectivity through SAR presented in figures. This will further provide a better outlook or fulfills the challenges faced in the development of novel benzimidazole derivatives as anticancer.

Synthesis and evaluation of new benzimidazole derivatives with hydrazone moiety as anticancer agents

2018 ◽  
Vol 43 (2) ◽  
pp. 151-158 ◽  
Author(s):  
Ulviye Acar Çevik ◽  
Begüm Nurpelin Sağlık ◽  
Cankız Mina Ardıç ◽  
Yusuf Özkay ◽  
Özlem Atlı
Keyword(s):  
Cytotoxic Activity ◽  
Anticancer Agents ◽  
Point Of View ◽  
Current Therapy ◽  
Benzimidazole Derivatives ◽  
Anticancer Activities ◽  
New Chemical Entities ◽  
Nih 3T3 ◽  
Mcf 7

Abstract Objectives: Cancer is one of the leading causes of death throughout the world. Current therapy options suffer from the major limitations of side effects and drug resistance. Thus, continuing search for newer and safer anticancer drugs remains critically important. From this point of view, in the present study benzimidazole-hydrazone derivatives were synthesized by aiming at the identification of new chemical entities as potent anticancer agents. Material and methods: A series of 12 new compounds of 4-(5(6)-substituted-1H-benzimidazol-2-yl)-N′thiophen/furan-2-yl-methylene) benzohydrazide derivatives were synthesized. The structures of the obtained compounds were elucidated using by IR, 1H NMR, 13C NMR, mass spectroscopy and elemental analyses. In vitro cytotoxic activity of the compounds against A549, MCF-7 and NIH/3T3 cell lines was evaluated by MTT assay. Results: Among the tested compounds, compound 3e showed higher cytotoxicity against MCF-7 human breast cancer cells when compared with cisplatin. Also, it has lower cytotoxicty against healthy cell line, NIH/3T3. Conclusions: It was determined that compound 3e showed inhibition towards MCF-7. Considering the substituent effect on cytotoxic activity, compound 3e bearing 2-methylthiophene has attracted attention with its higher anticancer activities.

Synthesis and Biological Evaluation of Some 1,2-Disubstituted Benzimidazole Derivatives as New Potential Anticancer Agents

2013 ◽  
Vol 346 (5) ◽  
pp. 403-414 ◽  
Author(s):  
Leyla Yurttaş ◽  
Şeref Demirayak ◽  
Gülşen A. Çiftçi ◽  
Şafak Ulusoylar Yıldırım ◽  
Zafer A. Kaplancıklı
Keyword(s):  
Anticancer Agents ◽  
Biological Evaluation ◽  
Benzimidazole Derivatives ◽  
Synthesis And Biological Evaluation

Benzimidazole Derivatives as Potential Anticancer Agents

2013 ◽  
Vol 13 (3) ◽  
pp. 399-407
Author(s):  
Ahmed A. El Rashedy ◽  
Hassan Y. Aboul-Enein
Keyword(s):  
Anticancer Agents ◽  
Benzimidazole Derivatives

ChemInform Abstract: Synthesis and Biological Evaluation of Some 1,2-Disubstituted Benzimidazole Derivatives as New Potential Anticancer Agents.

ChemInform ◽  
2013 ◽  
Vol 44 (37) ◽  
pp. no-no
Author(s):  
Leyla Yurttas ◽  
Seref Demirayak ◽  
Guelsen A. Ciftci ◽  
Safak Ulusoylar Yildirim ◽  
Zafer A. Kaplancikli
Keyword(s):  
Anticancer Agents ◽  
Biological Evaluation ◽  
Benzimidazole Derivatives ◽  
Synthesis And Biological Evaluation

Synthesis and preliminary evaluation of selected 2-aryl-5(6)-nitro- 1H-benzimidazole derivatives as potential anticancer agents

2011 ◽  
Vol 34 (2) ◽  
pp. 181-189 ◽  
Author(s):  
Aurelio Romero-Castro ◽  
Ismael León-Rivera ◽  
Laura Citlalli Ávila-Rojas ◽  
Gabriel Navarrete-Vázquez ◽  
Alejandro Nieto-Rodríguez
Keyword(s):  
Anticancer Agents ◽  
Benzimidazole Derivatives ◽  
Preliminary Evaluation

scholarly journals Advances in Engineered Polymer Nanoparticle Tracking Platforms towards Cancer Immunotherapy—Current Status and Future Perspectives

Vaccines ◽  
2021 ◽  
Vol 9 (8) ◽  
pp. 935
Author(s):  
Ramar Thangam ◽  
Kapil D. Patel ◽  
Heemin Kang ◽  
Ramasamy Paulmurugan
Keyword(s):  
Cancer Immunotherapy ◽  
Anticancer Agents ◽  
Polymeric Nanoparticles ◽  
Current Status ◽  
Polymeric Nanocarriers ◽  
Therapeutic Drugs ◽  
Small Molecule Ligands ◽  
Recent Developments ◽  
Cancer Immunotherapies

Engineering polymeric nanoparticles for their shape, size, surface chemistry, and functionalization using various targeting molecules has shown improved biomedical applications for nanoparticles. Polymeric nanoparticles have created tremendous therapeutic platforms, particularly applications related to chemo- and immunotherapies in cancer. Recently advancements in immunotherapies have broadened this field in immunology and biomedical engineering, where “immunoengineering” creates solutions to target translational science. In this regard, the nanoengineering field has offered the various techniques necessary to manufacture and assemble multifunctional polymeric nanomaterial systems. These include nanoparticles functionalized using antibodies, small molecule ligands, targeted peptides, proteins, and other novel agents that trigger and encourage biological systems to accept the engineered materials as immune enhancers or as vaccines to elevate therapeutic functions. Strategies to engineer polymeric nanoparticles with therapeutic and targeting molecules can provide solutions for developing immune vaccines via maintaining the receptor storage in T- and B cells. Furthermore, cancer immunotherapy using polymeric nanomaterials can serve as a gold standard approach for treating primary and metastasized tumors. The current status of the limited availability of immuno-therapeutic drugs highlights the importance of polymeric nanomaterial platforms to improve the outcomes via delivering anticancer agents at localized sites, thereby enhancing the host immune response in cancer therapy. This review mainly focuses on the potential scientific enhancements and recent developments in cancer immunotherapies by explicitly discussing the role of polymeric nanocarriers as nano-vaccines. We also briefly discuss the role of multifunctional nanomaterials for their therapeutic impacts on translational clinical applications.

Sign in / Sign up

Export Citation Format

Share Document