scholarly journals Antiplatelet Therapy after Coronary Artery Bypass Graft Surgery, Inconsistency of Clinical Practice and Clinical Significance of Proven Resistance to Antiplatelet Agents

2020 ◽  
Author(s):  
Ivana Sopek Merkas ◽  
Nenad Lakusic ◽  
Krunoslav Fuckar ◽  
Dusko Cerovec ◽  
Kristina Maric Besic
Keyword(s):  
Clinical Practice ◽  
Coronary Artery ◽  
Coronary Artery Bypass Graft ◽  
Antiplatelet Therapy ◽  
Coronary Artery Bypass ◽  
Clinical Significance ◽  
Artery Bypass ◽  
Bypass Graft ◽  
Antiplatelet Agents ◽  
Artery Bypass Graft

scholarly journals Increased risk of atrial fibrillation among patients undergoing coronary artery bypass graft surgery while receiving nitrates and antiplatelet agents

2018 ◽  
Vol 46 (8) ◽  
pp. 3183-3194 ◽  
Author(s):  
Jimmy T. Efird ◽  
Charulata Jindal ◽  
Andy C. Kiser ◽  
Shahab A. Akhter ◽  
Patricia B. Crane ◽  
...  
Keyword(s):  
Atrial Fibrillation ◽  
Coronary Artery ◽  
Coronary Artery Bypass Graft ◽  
Coronary Artery Bypass ◽  
Artery Bypass ◽  
Bypass Graft ◽  
Antiplatelet Agents ◽  
Guanosine Monophosphate ◽  
Artery Bypass Graft ◽  
Cabg Surgery

Background Postoperative atrial fibrillation (POAF) is a frequent complication of coronary artery bypass graft (CABG) surgery. This arrhythmia occurs more frequently among patients who receive perioperative inotropic therapy (PINOT). Administration of nitrates with antiplatelet agents reduces the conversion rate of cyclic guanosine monophosphate to guanosine monophosphate. This process is associated with increased concentrations of free radicals, catecholamines, and blood plasma volume. We hypothesized that patients undergoing CABG surgery who receive PINOT may be more susceptible to POAF when nitrates are administered with antiplatelet agents. Methods Clinical records were examined from a prospectively maintained cohort of 4,124 patients undergoing primary isolated CABG surgery to identify POAF-associated factors. Results POAF risk was increased among patients receiving PINOT, and the greatest effect was observed when nitrates were administered with antiplatelet therapy. Adjustment for comorbidities did not substantively change the study results. Conclusions Administration of nitrates with certain antiplatelet agents was associated with an increased POAF risk among patients undergoing CABG surgery. Additional studies are needed to determine whether preventive strategies such as administration of antioxidants will reduce this risk.

A systematic review of guidelines for dual antiplatelet therapy in coronary artery bypass graft

2020 ◽  
Vol 51 (1) ◽  
Author(s):  
Zheng‐zhi‐peng Zhang ◽  
Shao‐zhao Zhang ◽  
Hui‐min Zhou ◽  
Yong‐qiang Fan ◽  
Meng‐hui Liu ◽  
...  
Keyword(s):  
Systematic Review ◽  
Coronary Artery ◽  
Coronary Artery Bypass Graft ◽  
Antiplatelet Therapy ◽  
Coronary Artery Bypass ◽  
Dual Antiplatelet Therapy ◽  
Artery Bypass ◽  
Bypass Graft ◽  
Artery Bypass Graft
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