scholarly journals Human Contraceptives: Current Status, Sperm Antigen Inhibitors and an Insight into PCSK4

2020 ◽  
Author(s):  
Dahril Dahril ◽  
Widi Nugroho ◽  
Aulanni’am Aulanni’am
Keyword(s):  
Current Status ◽  
Insight Into ◽  
Sperm Antigen

Antibacterial and Anti-Biofilm Biosynthesised Silver and Gold Nanoparticles for Medical Applications: Mechanism of Action, Toxicity and Current Status

2020 ◽  
Vol 17 (2) ◽  
pp. 88-100 ◽  
Author(s):  
Sundos Suleman Ismail Abdalla ◽  
Haliza Katas ◽  
Fazren Azmi ◽  
Mohd Fauzi Mh Busra
Keyword(s):  
Gold Nanoparticles ◽  
Synthesis Method ◽  
Chemical Characterization ◽  
Current Status ◽  
Silver And Gold Nanoparticles ◽  
Physical And Chemical Characterization ◽  
Biosynthesized Agnps ◽  
Physical And Chemical ◽  
Insight Into ◽  
Bio Synthesis

Fast progress in nanoscience and nanotechnology has contributed to the way in which people diagnose, combat, and overcome various diseases differently from the conventional methods. Metal nanoparticles, mainly silver and gold nanoparticles (AgNPs and AuNPs, respectively), are currently developed for many applications in the medical and pharmaceutical area including as antibacterial, antibiofilm as well as anti-leshmanial agents, drug delivery systems, diagnostics tools, as well as being included in personal care products and cosmetics. In this review, the preparation of AgNPs and AuNPs using different methods is discussed, particularly the green or bio- synthesis method as well as common methods used for their physical and chemical characterization. In addition, the mechanisms of the antimicrobial and anti-biofilm activity of AgNPs and AuNPs are discussed, along with the toxicity of both nanoparticles. The review will provide insight into the potential of biosynthesized AgNPs and AuNPs as antimicrobial nanomaterial agents for future use.

Upcoming Drifts In Bio-Similars

2020 ◽  
Vol 15 ◽  
Author(s):  
Geeta Aggarwal ◽  
Manju Nagpal ◽  
Ameya Sharma ◽  
Vivek Puri ◽  
Gitika Arora Dhingra
Keyword(s):  
Metabolic Diseases ◽  
Market Competition ◽  
Current Status ◽  
Medicinal Products ◽  
The Past ◽  
Biologic Activity ◽  
Emerging Trends ◽  
Regulatory Guidelines ◽  
Food Drug Administration ◽  
Insight Into

Background: Biopharmaceuticals such as Biologic medicinal products have been in clinical use over the past three decades and have benefited towards the therapy of degenerative and critical metabolic diseases. It is forecasted that market of biologics will be going to increase at a rate of 20% per year, and by 2025, more than ˃ 50% of new drug approvals may be biological products. The increasing utilization of the biologics necessitates for cost control, especially for innovators products that have enjoyed a lengthy period of exclusive use. As the first wave of biopharmaceuticals is expired or set to expire, it has led to various opportunities for the expansion of bio-similars i.e. copied versions of original biologics with same biologic activity. Development of biosimilars is expected to promote market competition, meet worldwide demand, sustain the healthcare systems and maintain the incentives for innovation. Methods: Appraisal of published articles from peer reviewed journals, PubMed literature, latest news and guidelines from European Medicine Agency, US Food Drug Administration (FDA) and India are used to identify data for review. Results: Main insight into the quality requirements concerning biologics, current status of regulation of biosimilars and upcoming challenges lying ahead for the upgrading of marketing authorization of bio-similars has been incorporated. Compiled literature on therapeutic status, regulatory guidelines and the emerging trends and opportunities of biosimilars has been thoroughly stated. Conclusion: Updates on biosimilars will support to investigate the possible impact of bio-similars on healthcare market.

scholarly journals Clinical Candidates Targeting the ATR–CHK1–WEE1 Axis in Cancer

Cancers ◽  
2021 ◽  
Vol 13 (4) ◽  
pp. 795
Author(s):  
Lukas Gorecki ◽  
Martin Andrs ◽  
Jan Korabecny
Keyword(s):  
Cell Cycle ◽  
Cancer Cells ◽  
Molecular Mechanisms ◽  
Patient Survival ◽  
Current Status ◽  
Future Perspectives ◽  
Phase Ii Trials ◽  
Anticancer Treatment ◽  
Positive Outlook ◽  
Insight Into

Selective killing of cancer cells while sparing healthy ones is the principle of the perfect cancer treatment and the primary aim of many oncologists, molecular biologists, and medicinal chemists. To achieve this goal, it is crucial to understand the molecular mechanisms that distinguish cancer cells from healthy ones. Accordingly, several clinical candidates that use particular mutations in cell-cycle progressions have been developed to kill cancer cells. As the majority of cancer cells have defects in G1 control, targeting the subsequent intra‑S or G2/M checkpoints has also been extensively pursued. This review focuses on clinical candidates that target the kinases involved in intra‑S and G2/M checkpoints, namely, ATR, CHK1, and WEE1 inhibitors. It provides insight into their current status and future perspectives for anticancer treatment. Overall, even though CHK1 inhibitors are still far from clinical establishment, promising accomplishments with ATR and WEE1 inhibitors in phase II trials present a positive outlook for patient survival.

scholarly journals Current Situation and Prospects of Evidence-Based Medicine in Russia Assessed by Physicians and Patients

2019 ◽  
Vol 47 (3) ◽  
pp. 123-143
Author(s):  
Natalia A. Vyatkina
Keyword(s):  
Evidence Based Medicine ◽  
Current Status ◽  
Pharmaceutical Companies ◽  
Criminal Prosecution ◽  
Evidence Based ◽  
Sources Of Information ◽  
Critical Situation ◽  
Based Medicine ◽  
Insight Into

The term "evidence-based medicine" is being increasingly used by various sources of information today, and becomes a discussion subject of professional communities and ordinary citizens. Apart from a brief insight into the origin and development of evidence-based medicine in the world and in Russia, the article deals with the anthropological analysis of the attitudes of the modern Russian physicians and patients towards both the understanding of the term and the current status, prospects and possible risks of the development of this discipline in our country. The views of respondents about the role of pharmaceutical companies, the state and the balance between the development and implementation of clinical guidelines and individual cases are considered. The article presents the arguments of patients about whether there is still a "physician blessed by God" and whether it is important for them that the person who they address for help works in the paradigm of evidence-based medicine. Physicians question whether healing itself is still an art, or evidence-based medicine has finally turned it into a business and well-organized mechanism, which could protect them from criminal prosecution in a critical situation.

Assessing the Readiness of Farmers Towards Cold Chain Management

2020 ◽  
pp. 1570-1587
Author(s):  
Rohit Joshi ◽  
Sudhanshu Joshi
Keyword(s):  
Cold Chain ◽  
Current Status ◽  
Consumer Prices ◽  
Fresh Food ◽  
Building Market ◽  
Farm Produce ◽  
Food Safety And Quality ◽  
Insight Into ◽  
Awareness Level

The purpose of the paper is to gain an insight into the current status of farmers' awareness and practices towards maintaining the postharvest cold chain. The related hypotheses are developed and tested. The major findings include- marginalized and small farms, literacy and poor awareness level are the main causes for the backwardness of Indian farmers. Also, lack of funds forces farmers to ignore the use of cold storage. Further, multi-intermediaries and fluctuating consumer prices result farmers in not getting fair share of the consumer rupee. One of the major challenges in front of fresh food industry in India is to reduce postharvest losses across the chain through increasing awareness level of famers towards cold chain, building market information systems to assist farmers in decision-making and improving food safety and quality of farm produce available in the market.

Web-Based Instructions

2010 ◽  
pp. 302-326
Author(s):  
Mohammed Saleh Al Balawi
Keyword(s):  
Higher Education ◽  
Faculty Attitudes ◽  
Faculty Members ◽  
Current Status ◽  
Critical Factors ◽  
Web Based ◽  
Factors Affecting ◽  
Higher Education System ◽  
Based Instruction ◽  
Insight Into

Factors affecting faculty decisions in the conventional university setup in Saudi Arabia for participating or not participating sin Web-based instruction (WBI) were investigated in this study. Incentives and barriers to WBI, faculty attitudes, and participants’ demographic information were also explored. The study was aimed to investigate the attitudes of the faculty members at three Saudi universities toward WBI in an effort to describe the current status of WBI in the Saudi higher education system. In addition, results of the study could also provide the Saudi universities and the faculty with insight into factors affecting adoption of WBI. Finally, since there have been few implementations of WBI across the country, it was important to explore how WBI is currently used in Saudi universities and to determine critical factors that could affect the implementation of WBI.

scholarly journals Use of artificial intelligence in imaging in rheumatology – current status and future perspectives

RMD Open ◽  
2020 ◽  
Vol 6 (1) ◽  
pp. e001063 ◽  
Author(s):  
Berend Stoel
Keyword(s):  
Artificial Intelligence ◽  
Deep Learning ◽  
Basic Research ◽  
Current Status ◽  
Future Perspectives ◽  
Clinical Imaging ◽  
The World ◽  
Human Interpretation ◽  
The Impact ◽  
Insight Into

After decades of basic research with many setbacks, artificial intelligence (AI) has recently obtained significant breakthroughs, enabling computer programs to outperform human interpretation of medical images in very specific areas. After this shock wave that probably exceeds the impact of the first AI victory of defeating the world chess champion in 1997, some reflection may be appropriate on the consequences for clinical imaging in rheumatology. In this narrative review, a short explanation is given about the various AI techniques, including ‘deep learning’, and how these have been applied to rheumatological imaging, focussing on rheumatoid arthritis and systemic sclerosis as examples. By discussing the principle limitations of AI and deep learning, this review aims to give insight into possible future perspectives of AI applications in rheumatology.

scholarly journals Two hundred years after a commercial marine turtle fishery: the current status of marine turtles nesting in the Cayman Islands

Oryx ◽  
2001 ◽  
Vol 35 (2) ◽  
pp. 145-151 ◽  
Author(s):  
Jonathan J. Aiken ◽  
Brendan J. Godley ◽  
Annette C. Broderick ◽  
Timothy Austin ◽  
Gina Ebanks-Petrie ◽  
...  
Keyword(s):  
Chelonia Mydas ◽  
Marine Turtle ◽  
Current Status ◽  
Cayman Islands ◽  
Eretmochelys Imbricata ◽  
Marine Turtles ◽  
Mature Adults ◽  
Large Populations ◽  
Sexually Mature ◽  
Insight Into

AbstractLarge populations of marine turtles breeding in the Cayman Islands were drastically reduced in the early 1800s. However, marine turtle nesting still occurs in the islands. The present-day status of this nesting population provides insight into the conservation of marine turtles, a long-lived species. In 1998 and 1999, the first systematic survey of marine turtle nesting in the Cayman Islands found 38 nests on 22 beaches scattered through the three islands. Three species were found: the green Chelonia mydas, hawksbill Eretmochelys imbricata and loggerhead Caretta caretta turtles. Comparison with other rookeries suggests that the small number of sexually mature adults surviving Cayman's huge perturbations may be impeding population recovery. This shows the need to implement conservation measures prior to massive reductions in population size.

A Critical Evaluation of Recent Gendered Publishing Trends in American Archaeology

2014 ◽  
Vol 79 (3) ◽  
pp. 522-540 ◽  
Author(s):  
Dana N. Bardolph
Keyword(s):  
Gender Equity ◽  
Knowledge Production ◽  
Critical Evaluation ◽  
Current Status ◽  
Gender Imbalance ◽  
American Antiquity ◽  
Future Directions ◽  
American Archaeology ◽  
The Relationship ◽  
Insight Into

This paper explores the relationship between gender identity and patterns of authorship in peer-reviewed journals as a lens for examining gendered knowledge production and the current status and visibility of men and women in American archaeology. Drawing on feminist theory and the feminist critique of science, I examine how gender imbalance and a lack of diversity continue to affect the work that archaeologists produce. The evaluation of publishing trends serves as a means to investigate knowledge valuation/validation in archaeology and lends insight into the control over archaeological narratives. Analysis of publicacion rates from 1990–2013 in a number of prestigious archaeology research journals (including American Antiquity) as well as smaller-scale regional journals reveals that strong gender differences persist in one of the major ways that data are disseminated to the American archaeological community. I suggest that these patterns are likely a result of authorial behavior, rather than editorial or reviewer bias, and conclude with a discussion of future directions for practitioners to pursue research on gender equity in the discipline.

scholarly journals Elite Sport and Leisure Sport in Hungary: The Double Trouble

2010 ◽  
Vol 49 (1) ◽  
pp. 72-77 ◽  
Author(s):  
Andrea Gál
Keyword(s):  
Current Status ◽  
Elite Sport ◽  
Small Country ◽  
Political Leaders ◽  
The Public ◽  
Sports Science ◽  
Hungarian Society ◽  
Hungarian Population ◽  
Sport Clubs ◽  
Insight Into

Elite Sport and Leisure Sport in Hungary: The Double TroubleThe main purpose of this study is to give insight into the current status of two big areas of sport in Hungary: elite sport and leisure sport. As the expression ‘double trouble’ in the title indicates, in Hungary there are several problems in both areas.Hungary is a small country, but its Olympic teams were traditionally very successful in the Games. However, at the 29th Olympic Games in Beijing, Hungarian athletes performed below expectations, winning only three gold medals. The sport's political leaders and the public were very disappointed, therefore many experts tried to analyse the main reasons for the failure. They suggested that there were four problems in the background: the continuous disintegration of the sport clubs system; the low prestige of coaches and professionals working in sport; insufficient financial support and its inadequate timing; and the deficiency of sports science and its health care background. The second trouble concerns the sporting habits of Hungarian society. The country has faced the same problem for many decades: only a very low percentage of the Hungarian population takes part regularly in leisure sport programs. The latest empirical research shows that more than 60% of Hungarians do not do sports with suitable regularity. In comparing previous research results, there are a few changes among Hungarians according to gender, age and status of residence.How can this double trouble be resolved, or at least, how could both areas be somewhat improved? In Hungary, it is not really an easy task.

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