The Genetic Aspects of Behçet’s Disease: Role of Cytokine Genes Polymorphisms

Cytokines ◽  
2020 ◽  
Author(s):  
Abdulrahman Al Asmari ◽  
Misbahul Arfin
Keyword(s):  
Behçet’S Disease ◽  
Behcet’S Disease ◽  
Behçet's Disease ◽  
Behcet's Disease ◽  
Cytokine Genes

Role of miR-146a rs2910164 and UTS2 rs228648 Genetic Variants in Behçet’s Disease

2021 ◽  
pp. 1-10
Author(s):  
Asmaa Kamal ◽  
Fatema T Elgengehy ◽  
Zahraa Elawady ◽  
Nahla A. Fawzy ◽  
Ola El Sisi
Keyword(s):  
Behçet’S Disease ◽  
Genetic Variants ◽  
Behcet’S Disease ◽  
Behçet's Disease ◽  
Behcet's Disease

scholarly journals French recommendations for the management of Behçet’s disease

2021 ◽  
Vol 16 (S1) ◽  
Author(s):  
Isabelle Kone-Paut ◽  
◽  
Stéphane Barete ◽  
Bahram Bodaghi ◽  
Kumaran Deiva ◽  
...  
Keyword(s):  
Behçet’S Disease ◽  
Behcet’S Disease ◽  
Behçet's Disease ◽  
Initial Assessment ◽  
Diagnostic Process ◽  
Behcet's Disease ◽  
Therapeutic Modalities ◽  
Clinical Presentations ◽  
Key Points

AbstractBehçet’s disease (BD) is a systemic variable vessel vasculitis that involves the skin, mucosa, joints, eyes, arteries, veins, nervous system and gastrointestinal system, presenting with remissions and exacerbations. It is a multifactorial disease, and several triggering factors including oral cavity infections and viruses may induce inflammatory attacks in genetically susceptible individuals. BD vasculitis involves different vessel types and sizes of the vascular tree with mixed-cellular perivascular infiltrates and is often complicated by recurrent thrombosis, particularly in the venous compartment. Several new therapeutic modalities with different mechanisms of action have been studied in patients with BD. A substantial amount of new data have been published on the management of BD, especially with biologics, over the last years. These important therapeutic advances in BD have led us to propose French recommendations for the management of Behçet’s disease [Protocole National de Diagnostic et de Soins de la maladie de Behçet (PNDS)]. These recommendations are divided into two parts: (1) the diagnostic process and initial assessment; (2) the therapeutic management. Thirty key points summarize the essence of the recommendations. We highlighted the main differential diagnosis of BD according to the type of clinical involvement; the role of genetics is also discussed, and we indicate the clinical presentations that must lead to the search for a genetic cause.

scholarly journals The Role of Th17 Cells in the Pathogenesis of Behcet’s Disease

2017 ◽  
Vol 6 (7) ◽  
pp. 74 ◽  
Author(s):  
Yuki Nanke ◽  
Toru Yago ◽  
Shigeru Kotake
Keyword(s):  
Behçet’S Disease ◽  
Th17 Cells ◽  
Behcet’S Disease ◽  
Behçet's Disease ◽  
Behcet's Disease

Role of γδ T cells in Behcet's disease

The Lancet ◽  
1996 ◽  
Vol 347 (9015) ◽  
pp. 1631-1632 ◽  
Author(s):  
J.S.H. Gaston ◽  
Adam Hasan ◽  
Farida Fortune ◽  
Amanda Wilson ◽  
Thomas Lehner
Keyword(s):  
T Cells ◽  
Behçet’S Disease ◽  
Behcet’S Disease ◽  
Behçet's Disease ◽  
Γδ T Cells ◽  
Behcet's Disease

scholarly journals Investigation of the role of interleukin-1 receptor antagonist VNTR variant on the Behçet’s disease

2018 ◽  
Vol 5 (1) ◽  
pp. 27-31
Author(s):  
Gul Dursun ◽  
Ayse Feyda Nursal ◽  
Helin Deniz Demir ◽  
Nevin Karakus ◽  
Osman Demir ◽  
...  
Keyword(s):  
Receptor Antagonist ◽  
Behçet’S Disease ◽  
Behcet’S Disease ◽  
Behçet's Disease ◽  
Interleukin 1 ◽  
Behcet's Disease ◽  
Interleukin 1 Receptor Antagonist

Expression levels of miR-21, miR-146b and miR-326 as potential biomarkers in Behcet's disease

2019 ◽  
Vol 13 (16) ◽  
pp. 1339-1348
Author(s):  
Golamreza Jadideslam ◽  
Khalil Ansarin ◽  
Ebrahim Sakhinia ◽  
Zohreh Babaloo ◽  
Alireza Abhari ◽  
...  
Keyword(s):  
Behçet’S Disease ◽  
Behcet’S Disease ◽  
Behçet's Disease ◽  
Study Groups ◽  
Cross Sectional Study ◽  
Cross Sectional ◽  
Behcet's Disease ◽  
Expression Rate ◽  
Eye Involvement

Aim: Behcet's disease (BD) is a vasculitis. Lines of evidence suggest miRNAs as diagnostic and prognostic markers in autoimmune diseases. This study was designed to investigate the potential role of miR-21, miR-146b and miR-326 as biomarkers for diagnosis, predicting organs involvement and measuring BD activity. Patients & methods: In this cross-sectional study, the study groups consisted of 46 BD patients and 70 age- and sex-matched healthy volunteers. The expression rates of three miRNAs were determined by quantitative real-time PCR. Results: Our results demonstrated significantly lower expression of miR-21 and miR-146b and higher expression of miR-326 in BD patients. MiR-21 expression rate in patients with severe eye involvement and miR-326 expression rate in patients with uveitis and severe eye involvement were increased. Conclusion: MiR-326 expression rate can be used as a biomarker for prediction of uveitis and severe eye involvement in patients with BD.

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