scholarly journals Adipose Tissue Inflammation and Metabolic Disorders

2019 ◽  
Author(s):  
Felipe Henriques ◽  
Alexander H. Bedard ◽  
Miguel Luiz Batista Júnior
Keyword(s):  
Adipose Tissue ◽  
Metabolic Disorders ◽  
Adipose Tissue Inflammation ◽  
Tissue Inflammation

scholarly journals α-Mangostin remodels visceral adipose tissue inflammation to ameliorate age-related metabolic disorders in mice

Aging ◽  
2019 ◽  
Vol 11 (23) ◽  
pp. 11084-11110 ◽  
Author(s):  
Dan Li ◽  
Qianyu Liu ◽  
Xiuqiang Lu ◽  
Zhengqiu Li ◽  
Chunming Wang ◽  
...  
Keyword(s):  
Adipose Tissue ◽  
Visceral Adipose Tissue ◽  
Metabolic Disorders ◽  
Adipose Tissue Inflammation ◽  
Tissue Inflammation ◽  
Age Related ◽  
Visceral Adipose

scholarly journals Impact of hematopoietic cyclooxygenase-1 deficiency on obesity-linked adipose tissue inflammation and metabolic disorders in mice

Metabolism ◽  
2013 ◽  
Vol 62 (11) ◽  
pp. 1673-1685 ◽  
Author(s):  
Viswanathan Saraswathi ◽  
Christopher J. Ramnanan ◽  
Anson W. Wilks ◽  
Cyrus V. Desouza ◽  
Amy A. Eller ◽  
...  
Keyword(s):  
Adipose Tissue ◽  
Metabolic Disorders ◽  
Adipose Tissue Inflammation ◽  
Tissue Inflammation ◽  
Cyclooxygenase 1

scholarly journals TLR9 regulates adipose tissue inflammation and obesity-related metabolic disorders

Obesity ◽  
2015 ◽  
Vol 23 (11) ◽  
pp. 2199-2206 ◽  
Author(s):  
Chun-Pyo Hong ◽  
Chang Ho Yun ◽  
Gil-Woo Lee ◽  
Areum Park ◽  
You-Me Kim ◽  
...  
Keyword(s):  
Adipose Tissue ◽  
Metabolic Disorders ◽  
Adipose Tissue Inflammation ◽  
Tissue Inflammation

scholarly journals Mechanism-Based Biomarker Prediction for Low-Grade Inflammation in Liver and Adipose Tissue

2021 ◽  
Vol 12 ◽  
Author(s):  
Jolanda H. M. van Bilsen ◽  
Willem van den Brink ◽  
Anita M. van den Hoek ◽  
Remon Dulos ◽  
Martien P. M. Caspers ◽  
...  
Keyword(s):  
Adipose Tissue ◽  
Strong Correlation ◽  
In Silico ◽  
Metabolic Disorders ◽  
Low Grade ◽  
Adipose Tissue Inflammation ◽  
Hepatic Inflammation ◽  
Tissue Specific ◽  
Tissue Inflammation ◽  
Low Grade Inflammation

Metabolic disorders, such as obesity and type 2 diabetes have a large impact on global health, especially in industrialized countries. Tissue-specific chronic low-grade inflammation is a key contributor to complications in metabolic disorders. To support therapeutic approaches to these complications, it is crucial to gain a deeper understanding of the inflammatory dynamics and to monitor them on the individual level. To this end, blood-based biomarkers reflecting the tissue-specific inflammatory dynamics would be of great value. Here, we describe an in silico approach to select candidate biomarkers for tissue-specific inflammation by using a priori mechanistic knowledge from pathways and tissue-derived molecules. The workflow resulted in a list of candidate markers, in part consisting of literature confirmed biomarkers as well as a set of novel, more innovative biomarkers that reflect inflammation in the liver and adipose tissue. The first step of biomarker verification was on murine tissue gene-level by inducing hepatic inflammation and adipose tissue inflammation through a high-fat diet. Our data showed that in silico predicted hepatic markers had a strong correlation to hepatic inflammation in the absence of a relation to adipose tissue inflammation, while others had a strong correlation to adipose tissue inflammation in the absence of a relation to liver inflammation. Secondly, we evaluated the human translational value by performing a curation step in the literature using studies that describe the regulation of the markers in human, which identified 9 hepatic (such as Serum Amyloid A, Haptoglobin, and Interleukin 18 Binding Protein) and 2 adipose (Resistin and MMP-9) inflammatory biomarkers at the highest level of confirmation. Here, we identified and pre-clinically verified a set of in silico predicted biomarkers for liver and adipose tissue inflammation which can be of great value to study future development of therapeutic/lifestyle interventions to combat metabolic inflammatory complications.

Flavonoids in adipose tissue inflammation and atherosclerosis: one arrow, two targets

2020 ◽  
Vol 134 (12) ◽  
pp. 1403-1432 ◽  
Author(s):  
Manal Muin Fardoun ◽  
Dina Maaliki ◽  
Nabil Halabi ◽  
Rabah Iratni ◽  
Alessandra Bitto ◽  
...  
Keyword(s):  
Adipose Tissue ◽  
Fruits And Vegetables ◽  
Metabolic Diseases ◽  
Therapeutic Agents ◽  
Adipose Tissue Inflammation ◽  
Cellular Mechanisms ◽  
Tissue Inflammation ◽  
Cholesterol Levels ◽  
Naturally Occurring ◽  
Pro Inflammatory Cytokines

Abstract Flavonoids are polyphenolic compounds naturally occurring in fruits and vegetables, in addition to beverages such as tea and coffee. Flavonoids are emerging as potent therapeutic agents for cardiovascular as well as metabolic diseases. Several studies corroborated an inverse relationship between flavonoid consumption and cardiovascular disease (CVD) or adipose tissue inflammation (ATI). Flavonoids exert their anti-atherogenic effects by increasing nitric oxide (NO), reducing reactive oxygen species (ROS), and decreasing pro-inflammatory cytokines. In addition, flavonoids alleviate ATI by decreasing triglyceride and cholesterol levels, as well as by attenuating inflammatory mediators. Furthermore, flavonoids inhibit synthesis of fatty acids and promote their oxidation. In this review, we discuss the effect of the main classes of flavonoids, namely flavones, flavonols, flavanols, flavanones, anthocyanins, and isoflavones, on atherosclerosis and ATI. In addition, we dissect the underlying molecular and cellular mechanisms of action for these flavonoids. We conclude by supporting the potential benefit for flavonoids in the management or treatment of CVD; yet, we call for more robust clinical studies for safety and pharmacokinetic values.

The Effect of Saxagliptin on Adipose Tissue Inflammation in Overweight and Obese Nondiabetic Subjects

Diabetes ◽  
2018 ◽  
Vol 67 (Supplement 1) ◽  
pp. 1212-P ◽  
Author(s):  
JURAJ KOSKA ◽  
TRACY OSREDKAR ◽  
D'SOUZA KAREN ◽  
SANDEEP SINHA ◽  
CHRISTIAN MEYER ◽  
...  
Keyword(s):  
Adipose Tissue ◽  
Adipose Tissue Inflammation ◽  
Tissue Inflammation

Insulin Sensitizing Effects of Vitamin D Mediated through Reduced Adipose Tissue Inflammation and Fibrosis

Diabetes ◽  
2018 ◽  
Vol 67 (Supplement 1) ◽  
pp. 39-OR
Author(s):  
ERIC LONTCHI-YIMAGOU ◽  
SONA KANG ◽  
KEHAO ZHANG ◽  
AKANKASHA GOYAL ◽  
JEE YOUNG YOU ◽  
...  
Keyword(s):  
Vitamin D ◽  
Adipose Tissue ◽  
Adipose Tissue Inflammation ◽  
Tissue Inflammation

2032-P: Adipose Tissue Inflammation after Weight Loss

Diabetes ◽  
2020 ◽  
Vol 69 (Supplement 1) ◽  
pp. 2032-P
Author(s):  
ANA E. ESPINOSA DE YCAZA ◽  
ESBEN SØNDERGAARD ◽  
MARIA MORGAN-BATHKE ◽  
DANAE A. DELIVANIS ◽  
BARBARA G. CARRANZA LEON ◽  
...  
Keyword(s):  
Weight Loss ◽  
Adipose Tissue ◽  
Adipose Tissue Inflammation ◽  
Tissue Inflammation
Sign in / Sign up

Export Citation Format

Share Document