Antimicrobial Resistance and Rational Use of Antimicrobials in Livestock: Developing Countries’ Perspective

2020 ◽  
Author(s):  
Hans Ram Meena ◽  
Vikash Kumar
Keyword(s):  
Developing Countries ◽  
Antimicrobial Resistance ◽  
Rational Use

scholarly journals A survey of the knowledge and attitudes of Egyptian healthcare professionals towards the application of Health Information Technology to optimize antibiotic therapy

2021 ◽  
Vol 29 (Supplement_1) ◽  
pp. i28-i28
Author(s):  
N Hassan ◽  
R Slight ◽  
S P Slight
Keyword(s):  
Information Technology ◽  
Developing Countries ◽  
Antimicrobial Resistance ◽  
Health Information Technology ◽  
Health Information ◽  
Antimicrobial Stewardship ◽  
Healthcare Professionals ◽  
Response Rate ◽  
Public Healthcare ◽  
P Value

Abstract Introduction Antimicrobial resistance is a global health problem, especially in developing countries. Antimicrobial Stewardship Programmes (AMS) have been shown to be effective at reducing antimicrobial resistance and hospital patient stays. Health information technology (HIT) can support Outpatient Parenteral Antimicrobial Therapy (OPAT) through more accurate diagnosis and management of infectious diseases. Aim To evaluate the knowledge and attitude of Egyptian healthcare professionals towards the application of HIT to optimize OPAT. Methods Healthcare professionals who worked in either private or public sectors of Egyptian healthcare system were emailed and asked if they would be willing to complete an electronic questionnaire (using google forms). One reminder was sent by email each week for two weeks (two in total) from the first invitation. The survey was laid out in four sections. The first section included specific details about the healthcare professional’s current employment and role, the second related to HIT services available in their organisations, the third covered their training in HIT and antimicrobial stewardship programmes, and the fourth included their use of HIT to optimize OPAT. Ethical approval was obtained from National Heart Institute, Egypt. Descriptive analysis was carried out for all the variables. One-way ANOVA testing at level of significance P-value <0.05, was used to compare numerical variables. SPSS version 26 was used for statistical analysis. Results Three hundred and eighty-five healthcare professionals were invited to respond to the questionnaire. (The response rate was 75.34% (290)). Of these, 152 (52.6%) were pharmacists, 134 (46.4%) physicians, and 3 (1%) nurses, and many participants (30.8%) had between 6 to 10 years of experience working in either outpatient or in-patient units. Only 15.2% of respondents mentioned that they have access to OPAT in their organizations, 51.2% did not have the service, while 33.6% responded that they did not know if the service was available. However, 27.3% had a training on ASP and 18.3% had a training on HIT. Mean scores for both knowledge (14.31±5.49) and attitude (14.67±2.53) were significantly higher in professionals who had received training in HIT (p = 0.003 & 0.006 respectively). However, scores for attitude were better than scores for knowledge. Conclusions In developing countries, HIT applications in OPAT are still in their infancy with only a few organisations adopting them. Egyptian healthcare professionals showed positive attitudes towards HIT use, especially when their knowledge was improved through training. Two strengths of this study include our high response rate and the wide breadth of different healthcare professionals who responded from both private and public healthcare settings. However, being a questionnaire, some questions were left unanswered and some respondents may not have been aware of their reasons for a particular answer. That said, this study has important implications for practice, with more awareness amongst healthcare professionals required on the availability of HIT services in their hospitals and how further training may be needed on the applications of HIT in optimizing OPAT.

scholarly journals Practice of dispensing antimicrobial medicines from community pharmacies

2020 ◽  
Vol 30 (Supplement_5) ◽  
Author(s):  
A Amirkhanyan ◽  
L Vardanyan ◽  
A Sevikyan ◽  
I Kazaryan ◽  
M Melikyan
Keyword(s):  
Antimicrobial Resistance ◽  
Public Awareness ◽  
Family Members ◽  
Professional Knowledge ◽  
Community Pharmacies ◽  
Rational Use ◽  
Rational Use Of Medicines ◽  
Inappropriate Use ◽  
Otc Medicines

Abstract Background Inappropriate use of antimicrobial medicines is one of the main causes of antimicrobial resistance (AMR). The objective of this work was to study the situation on dispensing antimicrobials from pharmacy outlets in Armenia. Methods The study was implemented in 30 community pharmacies from different regions of Yerevan. Medicines dispensed to 900 patients/caregivers (30 visitors in each pharmacy outlet) were analyzed. The following indicators were calculated: the percentage of antimicrobials prescribed by physicians, the percentage of visitors, who got antimicrobials without providing a prescription and so on. Results Antimicribials (n = 171) consisted 11.3% of all the dispensed medicines (N = 1513). Only 25 (14.6%) antimicrobials were dispensed to visitors who had prescriptions. Only 19 (12.6%) of 151 medicines provided without prescription were OTC-medicines, other 132 (87.4%) were prescription only medicines. According to information received from visitors, 58.5% of all dispensed antimicrobials were selected by physicians, 10.5% of antimicrobials were advised by pharmacists and almost one third was selected by patients, family members, etc. More than 90% of the total number of visitors, whom antimicrobials were dispensed, got them without providing a prescription. 13 patients received 2 and more antimicrobials. Conclusions Many prescription only antimicrobials are dispensed from community pharmacies without prescription and some medicines are not prescribed by physicians. That means many antimicrobials are used inappropriately. There is need in strategy that could prevent dispensing antimicrobials without prescription. Key messages Dispensing prescription only antimicrobials without prescription can compromise rational use of medicines. Professional knowledge and public awareness about AMR should be improved.

scholarly journals A study on antibiotic prescription among the hospitalized pediatric patients at a referral center in Puducherry, India

2017 ◽  
Vol 4 (3) ◽  
pp. 700
Author(s):  
M. Bala Gopal ◽  
P. Thiyagarajan ◽  
Vinayagamoorthy Venugopal ◽  
Venkata Naveen Kumar
Keyword(s):  
Infectious Disease ◽  
Developing Countries ◽  
Antimicrobial Resistance ◽  
Significant Proportion ◽  
Antibiotic Use ◽  
Hospitalized Children ◽  
Referral Centre ◽  
Cross Sectional ◽  
Microbial Resistance ◽  
The Cost

Background: Antimicrobial resistance has reached to a significant proportion globally. This antimicrobial resistance increases the cost of health care in addition to the existing burden of the prevalence of infectious disease in developing countries. We need to have institutional protocols based on the standard guidelines. It is important for the clinician to use antibiotics only when it is necessary. The aim of the study was to analyze the rationality of the antibiotics used among the hospitalized children in the referral centre located in the rural area, to evaluate the pattern of antibiotics prescribed among the hospitalized children and to find out the factors associated with the usage of antibiotics among them.  Methods: Analytical, cross sectional study was performed on all patients admitted to the inpatient pediatric medical service at a referral centre situated in the rural part of the Puducherry, India during the period from July 2015 to June 2016. Results: 959 children were included in our study.607 children belong to less than 5 years of age group. Overall 60% of the children have received either oral or parenteral antibiotics. Based on the categorization of children as per the final clinical diagnosis children requiring antibiotic, can be used and not required are 13% (125), 38.6% (370) and 48.4% (464) respectively. Respiratory, gastrointestinal and systemic infectious diseases were the major group of cases admitted in our centre. Antibiotic use in respiratory and systemic infectious disease were maximum with 248 (70.1%) and 179 (71.6%) respectively. Among the antibiotics cephalosporin, penicillin group and azithromycin constitute more than 90% of the antibiotics prescribed cases.Conclusions: Overuse of antibiotic is universal and seen in both developed and developing countries. This increases the cost of treatment and increases the chances of microbial resistance. As per the W.H.O. recommendations surveillance system is required in all the hospitals to assess the antibiotic use and to monitor the prevalence of microbial resistance. 

Plant-Derived Natural Alkaloids as New Antimicrobial and Adjuvant Agents in Existing Antimicrobial Therapy

2019 ◽  
Vol 20 (14) ◽  
pp. 1409-1433 ◽  
Author(s):  
Rajinder Pal Mittal ◽  
Vikas Jaitak
Keyword(s):  
Antimicrobial Activity ◽  
Developing Countries ◽  
Antimicrobial Resistance ◽  
Secondary Metabolites ◽  
Infectious Diseases ◽  
Antimicrobial Agents ◽  
Pathogenic Microorganisms ◽  
Proper Treatment ◽  
Natural Agents ◽  
Death Causes

Infectious diseases, instigated by pathogenic microorganisms are the cause of numerous health problems in developing countries. Infectious diseases got a place in the list of top ten death causes worldwide. The reason behind that level of severity is antimicrobial resistance. Antimicrobial resistance makes the antimicrobial agents useless when used in the treatment of infectious diseases. Microbes have very smartly achieved resistance against synthetic and semi-synthetic antimicrobial agents for their survival. Therefore, the handling of these diseases has become challenging. The resistance developing power is the reason for their existence since a million years. Due to their highly dangerous nature, proper treatment of infectious diseases has become a topic of concern. This leads the scientists or researchers to focus their research towards natural agents. Plants synthesize secondary metabolites to cope up with biotic and abiotic changes in the environment. Alkaloids are one of the secondary metabolites, synthesized by plants. Alkaloids protect the plant from predators and help them to fight with pathogens. The protecting nature of alkaloids can be used as a strong weapon in battle with resistant microorganisms. The purpose of this review is to provide information about the antimicrobial activity of alkaloids obtained from different plants and their combination with synthetic antimicrobials. Their mechanism of action against microorganisms is also given in the review.

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