scholarly journals Lipid Polymer Hybrid Nanoparticles: A Novel Approach for Drug Delivery

2020 ◽  
Author(s):  
Nayab Tahir ◽  
Muhammad Tahir Haseeb ◽  
Asadullah Madni ◽  
Farzana Parveen ◽  
Muhammad Muzamil Khan ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Hybrid Nanoparticles ◽  
Polymer Hybrid ◽  
Novel Approach

scholarly journals Lipid-polymer hybrid nanoparticles: Development & statistical optimization of norfloxacin for topical drug delivery system

2017 ◽  
Vol 2 (4) ◽  
pp. 269-280 ◽  
Author(s):  
Vivek Dave ◽  
Renu Bala Yadav ◽  
Kriti Kushwaha ◽  
Sachdev Yadav ◽  
Swapnil Sharma ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Drug Delivery System ◽  
Delivery System ◽  
Statistical Optimization ◽  
Hybrid Nanoparticles ◽  
Topical Drug Delivery ◽  
Polymer Hybrid

scholarly journals Self-Assembled Lipid−Polymer Hybrid Nanoparticles: A Robust Drug Delivery Platform

ACS Nano ◽  
2008 ◽  
Vol 2 (8) ◽  
pp. 1696-1702 ◽  
Author(s):  
Liangfang Zhang ◽  
Juliana M. Chan ◽  
Frank X. Gu ◽  
June-Wha Rhee ◽  
Andrew Z. Wang ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Hybrid Nanoparticles ◽  
Polymer Hybrid ◽  
Delivery Platform ◽  
Self Assembled

Development and optimization of methotrexate-loaded lipid-polymer hybrid nanoparticles for controlled drug delivery applications

2017 ◽  
Vol 533 (1) ◽  
pp. 156-168 ◽  
Author(s):  
Nayab Tahir ◽  
Asadullah Madni ◽  
Vimalkumar Balasubramanian ◽  
Mubashar Rehman ◽  
Alexandra Correia ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Controlled Drug Delivery ◽  
Hybrid Nanoparticles ◽  
Polymer Hybrid ◽  
Drug Delivery Applications

Microfluidic Synthesis of Lipid-Polymer Hybrid Nanoparticles for Targeted Drug Delivery

MRS Advances ◽  
2016 ◽  
Vol 1 (29) ◽  
pp. 2155-2160
Author(s):  
Eri A. Takami ◽  
Folarin Erogbogbo
Keyword(s):  
Drug Delivery ◽  
Low Cost ◽  
Three Dimensional ◽  
Hybrid Nanoparticles ◽  
Dimensional Structure ◽  
Force Microscopy ◽  
Polymer Hybrid ◽  
Medical Issues ◽  
Transmission Electron ◽  
Size And Morphology

ABSTRACTLipid-polymer hybrid nanoparticles (LPHN) have great potential as drug delivery devices for treatment of serious medical issues such as cardiovascular disease, tuberculosis, and cancer. Nanoprecipitation is a commonly used method to synthesize LPHN in a low cost manner. However, this multi-step process proves to be difficult in consistently producing uniformly sized nanoparticles. Here we developed a microfluidic device that utilizes a three-channel pathway and mixer channel to synthesize uniformly sized LPHN in a controlled manner. Dynamic light scattering results of the microfluidic synthesized nanoparticles show decrease in diameter size from 140 nm to 40 nm as the Reynolds number of the channel inflow increases. Transmission electron microscopy confirms the size and morphology of the nanoparticles. Three dimensional structure of the LPHN were observed using atomic force microscopy. The production of higher quality nanoparticles using our microfluidics device can expedite the research and development process of drug delivering lipid polymer nanoparticles.

NiFe2O4/poly(ethylene glycol)/lipid–polymer hybrid nanoparticles for anti-cancer drug delivery

2020 ◽  
Vol 44 (42) ◽  
pp. 18162-18172
Author(s):  
K. S. Joshy ◽  
Robin Augustine ◽  
Anshida Mayeen ◽  
Susan M. Alex ◽  
Anwarul Hasan ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Ethylene Glycol ◽  
Nickel Ferrite ◽  
Hybrid Nanoparticles ◽  
Cancer Drug ◽  
Poly Ethylene Glycol ◽  
Polymer Hybrid ◽  
Anti Cancer ◽  
Poly Ethylene ◽  
Cancer Drug Delivery

The present study reports the fabrication of hybrid nanoparticles consisting of nickel ferrite (NFO) for anti cancer drug delivery.

scholarly journals Ultra-small lipid–polymer hybrid nanoparticles for tumor-penetrating drug delivery

Nanoscale ◽  
2016 ◽  
Vol 8 (30) ◽  
pp. 14411-14419 ◽  
Author(s):  
Diana Dehaini ◽  
Ronnie H. Fang ◽  
Brian T. Luk ◽  
Zhiqing Pang ◽  
Che-Ming J. Hu ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Hybrid Nanoparticles ◽  
Polymer Hybrid

scholarly journals Assessment of the hepatoprotective effect of developed lipid-polymer hybrid nanoparticles (LPHNPs) encapsulating naturally extracted β-Sitosterol against CCl4 induced hepatotoxicity in rats

2019 ◽  
Vol 9 (1) ◽  
Author(s):  
Ebtsam M. Abdou ◽  
Marwa A. A. Fayed ◽  
Doaa Helal ◽  
Kawkab A. Ahmed
Keyword(s):  
Drug Delivery ◽  
Drug Delivery System ◽  
Delivery System ◽  
Liver Lipid ◽  
Entrapment Efficiency ◽  
Inhibitory Effect ◽  
Hepatoprotective Effect ◽  
Hybrid Nanoparticles ◽  
Histological Structure ◽  
Polymer Hybrid

AbstractThe hepatoprotective effect of β-Sitosterol (BSS), a natural phytosterol, after being formulated into a suitable pharmaceutical drug delivery system has not been widely explored. BSS was isolated from Centaurea pumilio L., identified and formulated as lipid-polymer hybrid nanoparticles (LPHNPs) using the poly(D,L-lactide-co-glycolide) polymer and DSPE-PEG-2000 lipid in different ratios. The selected formulation, prepared with a lipid: polymer: drug ratio of 2:2:2, had an entrapment efficiency (EE%) of 94.42 ± 3.8, particle size of 181.5 ± 11.3 nm, poly dispersity index (PDI) of 0.223 ± 0.06, zeta potential of −37.34 ± 3.21 and the highest drug release after 24 h. The hepatoprotective effect of the formulation at two different doses against CCl4 induced hepatotoxicity was evaluated in rats. The results showed that the BSS-LPHNPs (400 mg/kg) have the ability to restore the liver enzymes (alanine aminotransferase (ALT) and aspartate aminotransferase (AST)), liver lipid peroxidation markers (malondialdehyde (MDA) and catalase (CAT)), total bilirubin and albumin to their normal levels without inhibitory effect on the CYP2E1 activity. Also, the formulation could maintain the normal histological structure of liver tissue and decrease the cleaved caspase-3 expression. LPHNPs formulation encapsulating natural BSS is a promising hepatoprotective drug delivery system.

Layer-by-layer coated lipid–polymer hybrid nanoparticles designed for use in anticancer drug delivery

2014 ◽  
Vol 102 ◽  
pp. 653-661 ◽  
Author(s):  
Thiruganesh Ramasamy ◽  
Tuan Hiep Tran ◽  
Ju Yeon Choi ◽  
Hyuk Jun Cho ◽  
Jeong Hwan Kim ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Anticancer Drug ◽  
Hybrid Nanoparticles ◽  
Layer By Layer ◽  
Anticancer Drug Delivery ◽  
Polymer Hybrid
Sign in / Sign up

Export Citation Format

Share Document