Breaking down the Barrier: Topical Liposomes as Nanocarriers for Drug Delivery into the Posterior Segment of the Eyeball

2020 ◽  
Author(s):  
Arturo Santos ◽  
Juan C. Altamirano-Vallejo ◽  
José Navarro-Partida ◽  
Alejandro González-De la Rosa ◽  
Jane H. Hsiao
Keyword(s):  
Drug Delivery ◽  
Posterior Segment

Thermoresponsive Gel Drug Delivery for Retina and Posterior Segment Disease

2018 ◽  
pp. 397-409
Author(s):  
Komal Parmar ◽  
Jayvadan K. Patel ◽  
Deepak Bhatia ◽  
Yashwant V. Pathak
Keyword(s):  
Drug Delivery ◽  
Posterior Segment ◽  
Thermoresponsive Gel

scholarly journals In-vivo Evaluation and Characterization of Novel In-Situ Gelling System as Controlled Delivery System Containing Ciprofloxacin for Ocular Drug Delivery

2020 ◽  
Vol 10 (5-s) ◽  
pp. 32-39
Author(s):  
Fatima Eram ◽  
, Vivek
Keyword(s):  
Drug Delivery ◽  
Delivery System ◽  
Average Concentration ◽  
Posterior Segment ◽  
Ocular Infection ◽  
In Vivo Evaluation ◽  
Micro Emulsion ◽  
In Situ Gelling

Objectives: The purpose of this research was to develop the micro emulsion-based in situ gelling systems containing Ciprofloxacin for prophylaxis and treatment of the posterior segment diseases like endophthalmitis. Methods: Ciprofloxacin was encapsulated in small droplets owing to form microemulsion, and then the formed droplets were dispersed in a polymer solution that converted into a gel upon triggered by the electrolyte present in the tear fluid. Results: The formulation approach provides better absorption, penetration, retention, and improves the bioavailability of the drug. The average concentration reached into vitreous humor from topical microemulsion in situ gelling formulation was ~0.4 µg/ml, which is far more than the concentration required for therapeutic effect (i.e.  >0.047 µg/ml or >MIC90 for S. Epidermidis, a pathogen commonly responsible to cause endophthalmitis). Conclusion: Thus, novel micro emulsion-based in situ gelling formulation could be a potential drug delivery system for the treatment of posterior segment diseases like endophthalmitis. Keywords: Microemulsion, ciprofloxacin, endophthalmitis, ocular, infection, in situ

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