scholarly journals Essential Oils in the Development of New Medicinal Products

2020 ◽  
Author(s):  
Jason Jerry Atoche Medrano
Keyword(s):  
Essential Oils ◽  
Medicinal Products

Quantitative Removal of Pyrrolizidine Alkaloids from Essential Oils by the Hydrodistillation Step in Their Manufacturing Process

Planta Medica ◽  
2021 ◽  
Author(s):  
David S. Giera ◽  
Michael Preisitsch ◽  
Hugues Brevard ◽  
Jörn Nemetz
Keyword(s):  
Essential Oils ◽  
Manufacturing Process ◽  
Pyrrolizidine Alkaloids ◽  
Pyrrolizidine Alkaloid ◽  
Medicinal Products ◽  
Herbal Medicinal Products ◽  
Naturally Occurring ◽  
Herbal Medicinal ◽  
Set Up ◽  
Theoretical Considerations

AbstractPyrrolizidine alkaloids are naturally occurring toxins produced by certain weeds that can, if accidentally co-harvested, contaminate plant-based food, feed, and herbal medicinal products. Focusing on herbal medicinal products, the presence of pyrrolizidine alkaloids is restricted by regulatory prescribed thresholds to assure patient safety. Among the multitude of different herbal active substances utilized in herbal medicinal products, the class of pharmaceutically effective essential oils is considered to exhibit a negligible contribution to pyrrolizidine alkaloid contamination. Within the present investigation, this hypothesis should be scientifically scrutinized. For this purpose, an experimental set-up was chosen that reproduces the typical manufacturing step of hydrodistillation. Essential oils of eucalyptus and lemon were selected exemplarily and spiked with 3 representative pyrrolizidine alkaloids (retrorsine, retrorsine-N-oxide, and lycopsamine), whereupon hydrodistillation was performed. Analysis of the resulting distillates by LC-MS/MS proved that artificially added pyrrolizidine alkaloids were removed completely. Moreover, quantitative pyrrolizidine alkaloid recovery in the aqueous phases was observed. Hence, it was experimentally confirmed that herbal medicinal products employing hydrodistilled essential oils of pharmaceutical quality are intrinsically free of pyrrolizidine alkaloids due to the particularities of their manufacturing process. Furthermore, it can be concluded from theoretical considerations that essential oils produced by cold pressing have a negligible risk of carrying pyrrolizidine alkaloid contamination. Our findings provide a strong indication that the requirement for analytical pyrrolizidine alkaloid testing of essential oils for pharmaceutical use should be fundamentally reconsidered.

scholarly journals Chemical compositions of essential oils from two Artemisia species used in Mongolian traditional medicine

2018 ◽  
Vol 18 (44) ◽  
pp. 48-51
Author(s):  
Javzmaa N ◽  
Altantsetseg Sh ◽  
Shatar S ◽  
Amarjargal A
Keyword(s):  
Gas Chromatography ◽  
Essential Oils ◽  
Steppe Zone ◽  
Plant Diseases ◽  
Gas Chromatography Mass Spectrometry ◽  
Chemical Compositions ◽  
Medicinal Products ◽  
Diverse Range ◽  
The Family ◽  
Artemisia Species

Essential oils of aromatic and medicinal plants generally have a diverse range of activities because they possess many active constituents that work through a several modes of action. Artemisia, the largest genus of the family Asteraceae, has a number of effects against human and plant diseases. The main purpose of the present study was to investigate chemical compositions of essential oils of two Artemisia species, Artemisia palustris L and Artemisia sericea Weber ex Stechm from the Mongolian steppe zone using gas chromatography and gas chromatography-mass spectrometry. The essential oil of A.palustris was characterized by the presence of monoterpene hydrocarbons such as  trans-β-ocimene (59.1%), cis-β-ocimene (11.6%) and myrcene (7.1%), while the oil of A.sericea was dominated by the presence of three oxygenated monoterpenoids as 1,8-cineole (25.8%), borneol (22.5%) and camphor (18.8%) which are used for preparation of a fragrance and medicinal products.

Essential Oils and Related Products

1963 ◽  
Vol 35 (5) ◽  
pp. 5-0 ◽  
Author(s):  
James A. Rogers
Keyword(s):  
Essential Oils

New S-prenyl thioesters from essential oils of some Rutaceae

1980 ◽  
Vol 19 (5) ◽  
pp. 1537-1539 ◽  
Author(s):  
W Campbell
Keyword(s):  
Essential Oils

Gynecomastia Tied to Essential Oils

2007 ◽  
Vol 38 (3) ◽  
pp. 25
Author(s):  
MARY ANN MOON
Keyword(s):  
Essential Oils

Chemical composition and antimicrobial activity of the essential oils of flowers, leaves and stems of Cotinus coggygria

Planta Medica ◽  
2008 ◽  
Vol 74 (09) ◽  
Author(s):  
T Milošević ◽  
N Nićiforović ◽  
V Mihailović ◽  
S Solujić ◽  
N Vuković
Keyword(s):  
Antimicrobial Activity ◽  
Chemical Composition ◽  
Essential Oils ◽  
Cotinus Coggygria
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