scholarly journals Immune Alteration Caused by Fibrous and Particulate Environmental Substances

2020 ◽  
Author(s):  
Naoko Kumagai-Takei ◽  
Suni Lee ◽  
Kei Yoshitome ◽  
Nagisa Sada ◽  
Yasumitsu Nishimura ◽  
...  
Keyword(s):  
Immune Alteration

HIV DNA and Immune Alteration During Successful HAART

2013 ◽  
Vol 11 (4) ◽  
pp. 255-262 ◽  
Author(s):  
Diallo Mamadou ◽  
Zheng Yu-Huang ◽  
Chen Xia ◽  
He Bo ◽  
Zhou Hua-Ying ◽  
...  
Keyword(s):  
Immune Alteration ◽  
Hiv Dna

Early Disturbed Placental Ischemia and Hypoxia Creates Immune Alteration and Vascular Disorder Causing Preeclampsia

2014 ◽  
Vol 45 (7) ◽  
pp. 519-524 ◽  
Author(s):  
Arturo Zárate ◽  
Renata Saucedo ◽  
Jorge Valencia ◽  
Leticia Manuel ◽  
Marcelino Hernández
Keyword(s):  
Vascular Disorder ◽  
Immune Alteration ◽  
Placental Ischemia

scholarly journals Systemic Candidiasis and Cytomegalovirus Infection in the Setting of Artificial Cardiac Device Deployment

2015 ◽  
Author(s):  
Manoj Thangam ◽  
Bindu Akkanti ◽  
Maan Malahafio ◽  
Sriram Nathan ◽  
Indranee Rajapreyar ◽  
...  
Keyword(s):  
Heart Failure ◽  
Immune Function ◽  
Immune Modulation ◽  
Severe Heart Failure ◽  
Cardiac Device ◽  
Ventricular Assist ◽  
Cardiac Assist ◽  
Immune Alteration ◽  
Cardiac Assist Devices ◽  
Lymphocyte Activity

Heart failure is a serious cause of morbidity and mortality worldwide. The advent of implantable cardiac assist devices has generated a new arsenal for treating severe heart failure. However, the potential ramifications of ventricular assist device (VAD) usage are not fully understood. Immune modulation resulting from VAD implantation is an area of growing research. Although we do not fully understand the mechanisms contributing to host immune alteration, changes in cytokine concentrations, deceased lymphocyte activity, and the local effects of device materials have been shown to down regulate immune function. Infection is a serious complication that affects prognosis in this patient population. Malnutrition, critical status, and cardiovascular stress are additional predisposing factors in this fragile group. Driveline and surgery-associated infections are the most commonly identified culprits. However, decreased host immune function facilitates atypical infections including systemic fungemia and viremia. This case is an interesting example of a VAD associated immune system compromise.

scholarly journals Resveratrol in Autism Spectrum Disorders: Behavioral and Molecular Effects

Antioxidants ◽  
2020 ◽  
Vol 9 (3) ◽  
pp. 188 ◽  
Author(s):  
Michele Malaguarnera ◽  
Haroon Khan ◽  
Omar Cauli
Keyword(s):  
Oxidative Stress ◽  
Animal Models ◽  
Molecular Mechanisms ◽  
Autism Spectrum ◽  
Immune Alteration ◽  
Stress Markers ◽  
Behavioral Abnormalities ◽  
Spectrum Disorders ◽  
Core Symptoms ◽  
And Oxidative Stress

Resveratrol (RSV) is a polyphenolic stillbenoid with significant anti-oxidative and anti-inflammatory properties recently tested in animal models of several neurological diseases. Altered immune alteration and oxidative stress have also been found in patients with autism spectrum disorders (ASD), and these alterations could add to the pathophysiology associated with ASD. We reviewed the current evidence about the effects of RSV administration in animal models and in patients with ASD. RSV administration improves the core-symptoms (social impairment and stereotyped activity) in animal models and it also displays beneficial effects in other behavioral abnormalities such as hyperactivity, anxiety and cognitive function. The molecular mechanisms by which RSV restores or improves behavioral abnormalities in animal models encompass both normalization of central and peripheral immune alteration and oxidative stress markers and new molecular mechanisms such as expression of cortical gamma-amino butyric acid neurons, certain type of miRNAs that regulate spine growth. One randomized, placebo-controlled clinical trial (RCT) suggested that RSV add-on risperidone therapy improves comorbid hyperactivity/non-compliance, whereas no effects where seen in core symptoms of ASD No RCTs about the effect of RSV as monotherapy have been performed and the results from preclinical studies encourage its feasibility. Further clinical trials should also identify those ASD patients with immune alterations and/or with increased oxidative stress markers that would likely benefit from RSV administration.

Mechanistic Aspects of Stressor-Induced Immune Alteration

1994 ◽  
pp. 23-51 ◽  
Author(s):  
Bruce S. Rabin ◽  
Alex Kusnecov ◽  
Michael Shurin ◽  
Daohong Karp ◽  
Steffanie Rosnick
Keyword(s):  
Immune Alteration

scholarly journals Honeybee immunity and colony losses

Entomologia ◽  
2014 ◽  
Author(s):  
F. Nazzi ◽  
D. Annoscia ◽  
E. Caprio ◽  
G. Di Prisco ◽  
F. Pennacchio
Keyword(s):  
Molecular Mechanisms ◽  
Functional Model ◽  
Stress Factors ◽  
Integrated Analysis ◽  
Colony Losses ◽  
Deformed Wing Virus ◽  
Immune Alteration ◽  
Bee Colony ◽  
Parasitic Mite ◽  
Eventual Collapse

The decline of honeybee colonies and their eventual collapse is a widespread phenomenon in the Northern hemisphere of the globe, which severely limits the beekeeping industry. This dramatic event is associated with an enhanced impact of parasites and pathogens on honeybees, which is indicative of reduced immunocompetence. The parasitic mite Varroa destructor and the vectored viral pathogens appear to play a key-role in the induction of this complex syndrome. In particular, the Deformed Wing Virus (DWV) is widespread and is now considered, along with Varroa, one of the major causes of bee colony losses. Several lines of evidence indicate that this mite/DWV association severely affects the immune system of honeybees and makes them more sensitive to the action of other stress factors. The molecular mechanisms underpinning these complex interactions are currently being investigated and the emerging information has allowed the development of a new functional model, describing how different stress factors may synergistically concur in the induction of bee immune alteration and health decline. This provides a new logical framework in which to interpret the proposed multifactorial origin of bee colony losses and sets the stage for a more comprehensive and integrated analysis of the effect that multiple stress agents may have on honeybees.

scholarly journals Prolonged immune alteration following resolution of acute inflammation in humans

PLoS ONE ◽  
2017 ◽  
Vol 12 (10) ◽  
pp. e0186964 ◽  
Author(s):  
Madhur P. Motwani ◽  
Justine Newson ◽  
Simon Kwong ◽  
Angela Richard-Loendt ◽  
Romain Colas ◽  
...  
Keyword(s):  
Acute Inflammation ◽  
Immune Alteration

Microglial phagocytosis of polystyrene microplastics results in immune alteration and apoptosis in vitro and in vivo

2021 ◽  
pp. 150817
Author(s):  
Wookbong Kwon ◽  
Daehwan Kim ◽  
Hee-Yeon Kim ◽  
Sang-Won Jeong ◽  
Se-Guen Lee ◽  
...  
Keyword(s):  
Microglial Phagocytosis ◽  
Immune Alteration

Immune Alteration Associated with Exposure to Toxic Chemicals

1992 ◽  
Vol 8 (5) ◽  
pp. 239-254 ◽  
Author(s):  
Aristo Vojdani ◽  
Mamdooh Ghoneum ◽  
Nachman Brautbar
Keyword(s):  
T Cell ◽  
B Cell ◽  
Cell Function ◽  
Nk Cell ◽  
Phenotypic Expression ◽  
Chemical Exposure ◽  
Autoimmune Response ◽  
Manufacturing Plants ◽  
Immune Alteration ◽  
Activated T Cell

Immunological abnormalities including lymphocyte subset, lymphocyte immune functional assays, chemical antibodies, and different markers for autoimmune response were examined in individuals exposed to a variety of chemicals in computer manufacturing plants. A comparison of 289 individuals exposed to chemicals to 120 controls revealed that exposed individuals had a significantly higher percentage with either increased or decreased T helper/T suppressor ratios. In addition, the individuals with abnormal T4/T8 ratios demonstrated significant elevation in chemical-hapten antibodies. Therefore, 87 exposed subjects with abnormal T4/T8 ratios were selected for further evaluation by lymphocyte phenotypic expression and T cell, B cell, NK activity, and autoimmune markers, and were compared to 60 controls. The comparison of exposed individuals with controls indicated elevation of T cell (CD3), B cell (CD19), and activated T cell (CDJO, CDJS, CD26, CD38), suppressed T cell and B cell function decreased or increased NK cell cytotoxic activity. Autoimmunity due to chemical exposure was evidenced by elevation of TAJ phenotype frequencies and presence of rheumatoid factor, immune complexes, ANA, and anti mye/in basic protein antibodies. We conclude that chemical exposure may induce immune abnormalities including immune suppression and autoimmunity.

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