scholarly journals Introductory Chapter: DNA Repair in Human Cells - A Daily Challenge

2019 ◽  
Author(s):  
Maddalena Mognato
Keyword(s):  
Dna Repair ◽  
Human Cells

scholarly journals Molecular cloning and chromosomal localization of DNA sequences associated with a human DNA repair gene.

1985 ◽  
Vol 5 (2) ◽  
pp. 398-405 ◽  
Author(s):  
J S Rubin ◽  
V R Prideaux ◽  
H F Willard ◽  
A M Dulhanty ◽  
G F Whitmore ◽  
...  
Keyword(s):  
Dna Repair ◽  
Dna Sequences ◽  
Chromosomal Localization ◽  
Excision Repair ◽  
Repair Process ◽  
Human Cells ◽  
Gene Products ◽  
Repair Gene ◽  
Human Dna ◽  
Dna Repair Gene

The genes and gene products involved in the mammalian DNA repair processes have yet to be identified. Toward this end we made use of a number of DNA repair-proficient transformants that were generated after transfection of DNA from repair-proficient human cells into a mutant hamster line that is defective in the initial incision step of the excision repair process. In this report, biochemical evidence is presented that demonstrates that these transformants are repair proficient. In addition, we describe the molecular identification and cloning of unique DNA sequences closely associated with the transfected human DNA repair gene and demonstrate the presence of homologous DNA sequences in human cells and in the repair-proficient DNA transformants. The chromosomal location of these sequences was determined by using a panel of rodent-human somatic cell hybrids. Both unique DNA sequences were found to be on human chromosome 19.

scholarly journals DNA repair in human cells. Biochemistry of the hereditary diseases Fanconi's anaemia and Cockayne syndrome

1987 ◽  
Vol 165 (2) ◽  
pp. 235-242 ◽  
Author(s):  
Manfred SCHWEIGER ◽  
Bernhard AUER ◽  
Helmut J. BURTSCHER ◽  
Monica HIRSCH-KAUFFMANN ◽  
Helmut KLOCKER ◽  
...  
Keyword(s):  
Dna Repair ◽  
Cockayne Syndrome ◽  
Human Cells ◽  
Hereditary Diseases

scholarly journals Evidence for formation of DNA repair centers and dose-response nonlinearity in human cells

2011 ◽  
Vol 109 (2) ◽  
pp. 443-448 ◽  
Author(s):  
T. Neumaier ◽  
J. Swenson ◽  
C. Pham ◽  
A. Polyzos ◽  
A. T. Lo ◽  
...  
Keyword(s):  
Dna Repair ◽  
Dose Response ◽  
Human Cells

DNA Repair in Human Cells: Molecular Cloning of cDNAS Coding for Enzymes Related to Repair

2011 ◽  
Author(s):  
Manfred Schweiger ◽  
Rainer Schneider ◽  
Monica Hirsch-Kauffmann ◽  
Bernhard Auer ◽  
Helmut Klocker ◽  
...  
Keyword(s):  
Dna Repair ◽  
Molecular Cloning ◽  
Human Cells
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