scholarly journals Introductory Chapter: DNA Repair in Human Cells - A Daily Challenge

Author(s):  
Maddalena Mognato
Keyword(s):  
1985 ◽  
Vol 5 (2) ◽  
pp. 398-405 ◽  
Author(s):  
J S Rubin ◽  
V R Prideaux ◽  
H F Willard ◽  
A M Dulhanty ◽  
G F Whitmore ◽  
...  

The genes and gene products involved in the mammalian DNA repair processes have yet to be identified. Toward this end we made use of a number of DNA repair-proficient transformants that were generated after transfection of DNA from repair-proficient human cells into a mutant hamster line that is defective in the initial incision step of the excision repair process. In this report, biochemical evidence is presented that demonstrates that these transformants are repair proficient. In addition, we describe the molecular identification and cloning of unique DNA sequences closely associated with the transfected human DNA repair gene and demonstrate the presence of homologous DNA sequences in human cells and in the repair-proficient DNA transformants. The chromosomal location of these sequences was determined by using a panel of rodent-human somatic cell hybrids. Both unique DNA sequences were found to be on human chromosome 19.


1987 ◽  
Vol 165 (2) ◽  
pp. 235-242 ◽  
Author(s):  
Manfred SCHWEIGER ◽  
Bernhard AUER ◽  
Helmut J. BURTSCHER ◽  
Monica HIRSCH-KAUFFMANN ◽  
Helmut KLOCKER ◽  
...  

2011 ◽  
Vol 109 (2) ◽  
pp. 443-448 ◽  
Author(s):  
T. Neumaier ◽  
J. Swenson ◽  
C. Pham ◽  
A. Polyzos ◽  
A. T. Lo ◽  
...  
Keyword(s):  

Author(s):  
Manfred Schweiger ◽  
Rainer Schneider ◽  
Monica Hirsch-Kauffmann ◽  
Bernhard Auer ◽  
Helmut Klocker ◽  
...  

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