scholarly journals Current Status of Stem Cell Therapy for Sepsis and Acute Respiratory Distress Syndrome

2020 ◽  
Author(s):  
Raquel Guillamat-Prats ◽  
Antonio Artigas
Keyword(s):  
Acute Respiratory Distress Syndrome ◽  
Stem Cell ◽  
Cell Therapy ◽  
Respiratory Distress Syndrome ◽  
Respiratory Distress ◽  
Stem Cell Therapy ◽  
Distress Syndrome ◽  
Current Status

scholarly journals A current update in COVID-19 associated acute respiratory distress syndrome: Focus on mesenchymal stem cell therapy

2020 ◽  
Vol 24 (6) ◽  
Author(s):  
David Nugraha ◽  
Nabila Ananda Kloping ◽  
Resti Yudhawati ◽  
Azham Purwandhono ◽  
Hanik Badriyah Hidayati
Keyword(s):  
Stem Cells ◽  
Acute Respiratory Distress Syndrome ◽  
Stem Cell ◽  
Mesenchymal Stem Cell ◽  
Cell Therapy ◽  
Respiratory Distress Syndrome ◽  
Respiratory Distress ◽  
Distress Syndrome ◽  
Mesenchymal Stem Cell Therapy ◽  
A Current

Indonesia has been fighting the COVID-19 pandemic since the beginning of March 2020, and it doesn’t look that the situation is getting better any soon. Besides the country’s current strategies to minimize the rising mortality rate, a novel therapeutic intervention is required. After a thorough search in several databases, we found stem cells to be a likely candidate. Regardless of the general use of stem cells, studies showed positive results regarding the efficacy of using these in lung injuries. Especially, mesenchymal stem cells (MSCs) are known for their easy accessibility and their diverse mechanisms of action, including MSCs immunomodulatory antiviral effect, and its ability to improve lung function. Moreover, some researches perceived these components to be applicable in COVID-19 patients with end stage acute respiratory distress syndrome (ARDS). While randomized clinical trials are still in progress, many case reports show MSCs to be an advantageous alternative to suppress the cytokine storm and help regulate the immune system. This review summarizes the common functions of MSCs and highlights its therapeutic assets to fully tackle this global pandemic. Key word: Mesenchymal Stem Cells; Cell Therapy; COVID-19; SARS-CoV-2; ARDS Abbreviations: COVID-19 – Coronavirus Disease; MSC – Mesenchymal Stem Cell; ARDS – Acute Respiratory Distress Syndrome Citation: Nugraha D, Kloping NA, Yudhawati R, Purwandhono A, Hidayati HB. A current update in COVID-19 associated acute respiratory distress syndrome: Focus on mesenchymal stem cell therapy. Anaesth. pain intensive care 2020;24(6):--- Received: , Reviewed: , Revised: , Accepted:

scholarly journals Strategies to Enhance Mesenchymal Stem Cell-Based Therapies for Acute Respiratory Distress Syndrome

2019 ◽  
Vol 2019 ◽  
pp. 1-12 ◽  
Author(s):  
Jibin Han ◽  
Yanmin Li ◽  
Yuanyuan Li
Keyword(s):  
Acute Respiratory Distress Syndrome ◽  
Stem Cell ◽  
Respiratory Distress Syndrome ◽  
Respiratory Distress ◽  
Distress Syndrome ◽  
Therapeutic Potential ◽  
Large Body ◽  
Acute Onset ◽  
Trophic Factors ◽  
Preclinical Models

Acute respiratory distress syndrome (ARDS) is a multifaced disease characterized by the acute onset of hypoxemia, worsened pulmonary compliance, and noncardiogenic pulmonary edema. Despite over five decades of research, specific treatments for established ARDS are still lacking. MSC-based therapies have the advantage of targeting nearly all pathophysiological components of ARDS by means of a variety of secreted trophic factors, exerting anti-inflammatory, antioxidative, immunomodulatory, antiapoptotic, and proangiogenic effects, resulting in significant structural and functional recovery following ARDS in various preclinical models. However, the therapeutic efficacy of transplanted MSCs is limited by their poor engraftment and low survival rate in the injured tissues, major barriers to clinical translation. Accordingly, several strategies have been explored to improve MSC retention in the lung and enhance the innate properties of MSCs in preclinical models of ARDS. To provide a comprehensive and updated view, we summarize a large body of experimental evidence for a variety of strategies directed towards strengthening the therapeutic potential of MSCs in ARDS.

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