scholarly journals Inflammatory Muscle Diseases

2020 ◽  
Author(s):  
Doris Hissako Sumida ◽  
Fernando Yamamoto Chiba ◽  
Maria Sara de Lima Coutinho Mattera
Keyword(s):  
Muscle Diseases

Z-line degradation and phagocytosis of sarcomeric fragments in myonecrosis

1983 ◽  
Vol 41 ◽  
pp. 790-791
Author(s):  
Melinda L. Estes ◽  
Samuel M. Chou
Keyword(s):  
Vastus Lateralis ◽  
Inflammatory Myopathy ◽  
Muscle Disease ◽  
White Female ◽  
Inflammatory Cell Infiltrate ◽  
Limb Weakness ◽  
Muscle Diseases ◽  
History Of ◽  
The Right ◽  
Mononuclear Inflammatory Cell

Many muscle diseases show common pathological features although their etiology is different. In primary muscle diseases a characteristic finding is myofiber necrosis. The mechanism of myonecrosis is unknown. Polymyositis is a primary muscle disease characterized by acute and subacute degeneration as well as regeneration of muscle fibers coupled with an inflammatory infiltrate. We present a case of polymyositis with unusual ultrastructural features indicative of the basic pathogenetic process involved in myonecrosis.The patient is a 63-year-old white female with a one history of proximal limb weakness, weight loss and fatigue. Examination revealed mild proximal weakness and diminished deep tendon reflexes. Her creatine kinase was 1800 mU/ml (normal < 140 mU/ml) and electromyography was consistent with an inflammatory myopathy which was verified by light microscopy on biopsy muscle. Ultrastructural study of necrotizing myofiber, from the right vastus lateralis, showed: (1) degradation of the Z-lines with preservation of the adjacent Abands including M-lines and H-bands, (Fig. 1), (2) fracture of the sarcomeres at the I-bands with disappearance of the Z-lines, (Fig. 2), (3) fragmented sarcomeres without I-bands, engulfed by invading phagocytes, (Fig. 3, a & b ), and (4) mononuclear inflammatory cell infiltrate in the endomysium.

Muscle Diseases (Blue Books of Practical Neurology, vol 24)

2000 ◽  
Vol 57 (7) ◽  
pp. 1082-a-1083
Author(s):  
S. T. Iannaccone
Keyword(s):  
Muscle Diseases

Tropomyosin mutations responsible for muscle weakness in inherited skeletal muscle diseases

2008 ◽  
pp. 20-21
Author(s):  
Julien Ochala ◽  
Anders Oldfors ◽  
Lars Larsson
Keyword(s):  
Skeletal Muscle ◽  
Muscle Weakness ◽  
Muscle Diseases

scholarly journals Title: Gene transfer by pyro-drive jet injector is a novel therapeutic approach for muscle diseases

Gene ◽  
2021 ◽  
Vol 788 ◽  
pp. 145664
Author(s):  
Takafumi Nakae ◽  
Masanori Obana ◽  
Takahiro Maeda ◽  
Akari Ikeda ◽  
Hiroshi Miyazaki ◽  
...  
Keyword(s):  
Gene Transfer ◽  
Therapeutic Approach ◽  
Muscle Diseases ◽  
Novel Therapeutic

Dact1 is expressed during chicken and mouse skeletal myogenesis and modulated in human muscle diseases

2021 ◽  
pp. 110645
Author(s):  
Renata Erbert Contriciani ◽  
Fernanda Cristina da Veiga ◽  
Mariana Juliani do Amaral ◽  
Bianca Gazieri Castelucci ◽  
Lizandra Maia de Sousa ◽  
...  
Keyword(s):  
Human Muscle ◽  
Skeletal Myogenesis ◽  
Muscle Diseases

scholarly journals Enzymes and muscle diseases

Reumatismo ◽  
2011 ◽  
Vol 53 (2) ◽  
Author(s):  
M. Plebani
Keyword(s):  
Muscle Diseases

scholarly journals Duchenne Muscular Dystrophy - Family in a Crisis

1970 ◽  
pp. 36-39
Author(s):  
M Robed Amin ◽  
Chowdhury Chironjib Borua ◽  
Kaji Shafiqul Alam ◽  
Fazle Rabbi Chowdhury ◽  
Rabiul Jahan Sarkar ◽  
...  
Keyword(s):  
Duchenne Muscular Dystrophy ◽  
Muscular Dystrophy ◽  
Case Series ◽  
Dystrophin Gene ◽  
Muscle Disease ◽  
Motor Neuron Diseases ◽  
Muscle Diseases ◽  
Progressive Muscle Weakness ◽  
Recessive Disorders ◽  
Dystrophin Protein

Progressive muscular weakness with deformity leading to crippled states develop due to musculoskeletal and neurological disorders. Sometimes it is difficult to differentiate between primary muscle disease and neurological disease. But there is some classical presentation of muscle diseases which have its own entity and thus can be clinically differentiated from neurological disorder especially spinal cord and motor neuron diseases. Muscular dystrophy is one of those disorder with distinct clinical features. Muscular dystrophy refers to a group of genetic, hereditary muscle diseases that cause progressive muscle weakness. Most types of MD are multi-system disorders with manifestations in body systems including skeletal system, the heart, gastrointestinal and nervous systems, endocrine glands, skin, eyes and other organs. Duchenne muscular dystrophy (DMD), is inherited in an X-linked recessive pattern, meaning that the mutated gene that causes the disorder is located on the X chromosome, one of the two sex chromosomes, and is thus considered sex-linked. Males are therefore affected by X-linked recessive disorders much more often than females. A characteristic of X-linked inheritance is that fathers cannot pass X-linked traits to their sons. Duchenne muscular dystrophy and Backers muscular dystrophy are caused by mutations of the gene for the dystrophin protein and lead to an overabundance of the enzyme creatine kinase. The dystrophin gene is the largest gene in humans. In this case series a family with three brothers suffering from Duchenne muscular dystrophy is described and review with literature was done.   doi:10.3329/jom.v10i3.2015 J Medicine 2009; 10 (Supplement 1): 36-39

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