scholarly journals Anticancer Drugs’ Deoxyribonucleic Acid (DNA) Interactions

2020 ◽  
Author(s):  
Saad Hmoud Alotaibi ◽  
Awad Abdalla Momen
Keyword(s):  
Anticancer Drugs ◽  
Deoxyribonucleic Acid ◽  
Dna Interactions

ELECTROCHEMICAL DNA SENSOR TECHNOLOGY FOR MONITORING OF DRUG–DNA INTERACTIONS

NANO ◽  
2008 ◽  
Vol 03 (04) ◽  
pp. 229-232 ◽  
Author(s):  
A. ERDEM ◽  
H. KARADENIZ ◽  
A. CALISKAN ◽  
A. VASEASHTA
Keyword(s):  
Drug Delivery ◽  
Small Molecules ◽  
Anticancer Drugs ◽  
Point Of Care ◽  
Sensor Technology ◽  
Electrochemical Biosensors ◽  
Dna Sensor ◽  
Dna Interactions ◽  
Electrochemical Dna Sensor

The objective of this investigation is to understand the nature and dynamics of binding small molecules to bio-macromolecules using electrochemical methods. The investigation pertaining to the design of site- and conformation-specific reagents provides a rationale for new studies of drug delivery design. Some anticancer drugs and DNA interactions have been undertaken by using a variety of techniques. Determination of interaction between DNA and DNA-targeted molecules would be valuable in the design of molecule-specific electrochemical biosensors for applications in diagnostics, development of drugs for chemotherapy, and as a biotechnological tool for DNA-based point-of-care diagnosis.

Denaturation of deoxyribonucleic acid in situ effect of formaldehyde.

1975 ◽  
Vol 23 (6) ◽  
pp. 431-438 ◽  
Author(s):  
F Traganos ◽  
Z Darzyndiewicz ◽  
T Sharpless ◽  
M R Melamed
Keyword(s):  
Deoxyribonucleic Acid ◽  
Direct Action ◽  
Chromatin Condensation ◽  
Cross Linking ◽  
Dna Denaturation ◽  
Cell Type ◽  
Dna Interactions ◽  
Flow Through ◽  
Nuclear Deoxyribonucleic Acid

In situ denaturation of nuclear deoxyribonucleic acid (DNA) is studied by use of acridine orange to differentially stain native versus denatured DNA, and a flow-through cytofluorometer for measurements of cell fluorescence. Thermal- or acid-induced DNA denaturation is markedly influenced by formaldehyde. Two mechanisms of the formaldehyde action are distinguished. If cells are exposed to the agent during heating, DNA denaturation is facilitated, most likely by the direct action of formaldehyde as a "passive" denaturing agent on DNA. If cells are pretreated with formaldehyde which is then removed, DNA resistance to denaturation increases, presumably due to chromatin cross-linking. It is believed that both effects occur simultaneously in conventional techniques employing formaldehyde to study DNA in situ, and that the extent of each varies with the temperature and cell type (chromatin condensation). Thus, profiles of DNA denaturation of cells heated with formaldehyde do not represent characteristics of DNA denaturation in situ; DNA denaturation under these conditions is modulated by the reactivity of chromatin components with formaldehyde rather than by DNA interactions with the macromolecules of nuclear mileu.

Study of DNA Interactions with Steroidal and Nonsteroidal Estrogen–Platinum (II)–Based Anticancer Drugs

2009 ◽  
Vol 28 (1) ◽  
pp. 31-39 ◽  
Author(s):  
Emilie Froehlich ◽  
Atul Gupta ◽  
Josée Provencher-Mandeville ◽  
éric Asselin ◽  
Joseph Bariyanga ◽  
...  
Keyword(s):  
Anticancer Drugs ◽  
Dna Interactions

Effects of anticancer drugs on transcription factor–DNA interactions

2005 ◽  
Vol 9 (3) ◽  
pp. 471-489 ◽  
Author(s):  
Marek Gniazdowski ◽  
William A Denny ◽  
Stephanie M Nelson ◽  
Malgorzata Czyz
Keyword(s):  
Transcription Factor ◽  
Anticancer Drugs ◽  
Dna Interactions

Heritable and cancer risks of exposures to anticancer drugs: inter-species comparisons of covalent deoxyribonucleic acid-binding agents

1998 ◽  
Vol 400 (1-2) ◽  
pp. 509-540 ◽  
Author(s):  
Ekkehart W. Vogel ◽  
Alain Barbin ◽  
Madeleine J.M. Nivard ◽  
H.Frank Stack ◽  
Michael D. Waters ◽  
...  
Keyword(s):  
Anticancer Drugs ◽  
Deoxyribonucleic Acid ◽  
Cancer Risks ◽  
Binding Agents ◽  
Species Comparisons

Erythrocytes and the transfer of anticancer drugs and metabolites: A possible relationship with therapeutic outcome

2001 ◽  
Vol 28 (2F) ◽  
pp. 24-28 ◽  
Author(s):  
Herlinde Dumez ◽  
Martin Highley ◽  
Gunther Guetens ◽  
Gert De Boeck ◽  
Axel Hanauske ◽  
...  
Keyword(s):  
Anticancer Drugs ◽  
Therapeutic Outcome ◽  
Drugs And Metabolites
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