scholarly journals Evolving Concepts toward Individualized Treatment of Squamous Cell Carcinoma of the Anus

2020 ◽  
Author(s):  
Luc Dewit ◽  
Annemieke Cats ◽  
Geerard Beets
Keyword(s):  
Squamous Cell Carcinoma ◽  
Cell Carcinoma ◽  
Squamous Cell ◽  
Individualized Treatment

scholarly journals Therapeutic Effect of Combined Dabrafenib and Trametinib Treatment of BRAF V600E-Mutated Primary Squamous Cell Carcinoma of the Thyroid: A Case Report

2021 ◽  
pp. 1-6
Author(s):  
Tim Brandenburg ◽  
Philipp Muchalla ◽  
Sarah Theurer ◽  
Kurt Werner Schmid ◽  
Dagmar Führer
Keyword(s):  
Squamous Cell Carcinoma ◽  
Cell Carcinoma ◽  
Male Patient ◽  
Squamous Cell ◽  
Anaplastic Thyroid Carcinoma ◽  
Individualized Treatment ◽  
Braf V600e ◽  
Treatment Concept ◽  
Primary Squamous Cell Carcinoma ◽  
Rare Malignancy

<b><i>Introduction:</i></b> Primary squamous cell carcinoma (PSCC) of the thyroid is an exceptionally rare malignancy accounting for &#x3c;1% of all primary thyroid cancers. Therapy is multimodal including surgery, radiotherapy, and chemotherapy but with no consensus for management and therapy. Here, we describe a case of a male patient who presented with a BRAF V600E-mutated PSCC of the thyroid gland showing response to combined dabrafenib and trametinib therapy over a period of &#x3e;12 months. <b><i>Case Presentation:</i></b> A 78-year-old male patient presented with a 3-week history of dysphonia and dyspnoea. Laryngoscopy revealed a mechanical obstruction by a right-sided, subglottical mass, which on cervical ultrasound was highly suggestive of anaplastic thyroid carcinoma. Additional workup including esophagogastroduodenoscopy showed compression of the oesophagus but no oesophageal infiltration by the tumour. Immunohistochemistry displayed CK19-positive cells indicating epithelial origin of the tumour. CK5/6 and P40 immunohistochemistry confirmed the morphological impression of squamous cell differentiation while staining with thyroid markers TTF-1 and TPO was negative and PAX8 showed a nuclear positive signal. Based on immunohistopathology, presence of TP53 and BRAF V600E mutations, and exclusion of metastatic squamous cell carcinoma of other origin, the diagnosis of a PSCC of the thyroid was established. As an individualized treatment concept, we decided to advocate combined BRAF V600E targeting by the multikinase inhibitors dabrafenib and trametinib. This led to drastic improvement in patient’s quality of life without severe side effects over a period of &#x3e;12 months. <b><i>Conclusion:</i></b> In this case, molecular diagnosis allowed a highly individualized treatment concept with combined dabrafenib and trametinib therapy.

Squamous Cell Carcinoma of the Stomach

1960 ◽  
Vol 39 (6) ◽  
pp. 787-789 ◽  
Author(s):  
Kenneth Cruze ◽  
Harry E. Maas ◽  
James S. Clarke ◽  
Sabri el Farra
Keyword(s):  
Squamous Cell Carcinoma ◽  
Cell Carcinoma ◽  
Squamous Cell ◽  
Carcinoma Of The Stomach

591: The Significance of Single Microscopic Positive Sentinel Nodes in Penile Squamous Cell Carcinoma

2007 ◽  
Vol 177 (4S) ◽  
pp. 198-198
Author(s):  
Yuko Smith ◽  
Paul Hadway ◽  
Mark Lynch ◽  
Ben Hughes ◽  
Matthew J. Perry ◽  
...  
Keyword(s):  
Squamous Cell Carcinoma ◽  
Cell Carcinoma ◽  
Squamous Cell ◽  
Sentinel Nodes ◽  
Penile Squamous Cell Carcinoma
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