scholarly journals Therapeutic Potential of Articular Cartilage Regeneration using Tissue Engineering Based on Multiphase Designs

2019 ◽  
Author(s):  
Lizeth Fuentes-Mera ◽  
Alberto Camacho ◽  
Elisabeth Engel ◽  
Vanessa Pérez-Silos ◽  
Jorge Lara-Arias ◽  
...  
Keyword(s):  
Tissue Engineering ◽  
Articular Cartilage ◽  
Therapeutic Potential ◽  
Cartilage Regeneration ◽  
Articular Cartilage Regeneration

scholarly journals Articular Cartilage Regeneration in Osteoarthritis

Cells ◽  
2019 ◽  
Vol 8 (11) ◽  
pp. 1305 ◽  
Author(s):  
Livia Roseti ◽  
Giovanna Desando ◽  
Carola Cavallo ◽  
Mauro Petretta ◽  
Brunella Grigolo
Keyword(s):  
Tissue Engineering ◽  
Articular Cartilage ◽  
Cartilage Regeneration ◽  
Common Chronic Disease ◽  
Gene Therapies ◽  
Osteoarthritis Treatment ◽  
Challenges And Opportunities ◽  
Pros And Cons ◽  
Future Work ◽  
Articular Cartilage Regeneration

There has been considerable advancement over the last few years in the treatment of osteoarthritis, common chronic disease and a major cause of disability in older adults. In this pathology, the entire joint is involved and the regeneration of articular cartilage still remains one of the main challenges, particularly in an actively inflammatory environment. The recent strategies for osteoarthritis treatment are based on the use of different therapeutic solutions such as cell and gene therapies and tissue engineering. In this review, we provide an overview of current regenerative strategies highlighting the pros and cons, challenges and opportunities, and we try to identify areas where future work should be focused in order to advance this field.

scholarly journals The Application of Bioreactors for Cartilage Tissue Engineering: Advances, Limitations, and Future Perspectives

2021 ◽  
Vol 2021 ◽  
pp. 1-13
Author(s):  
Liwei Fu ◽  
Pinxue Li ◽  
Hao Li ◽  
Cangjian Gao ◽  
Zhen Yang ◽  
...  
Keyword(s):  
Tissue Engineering ◽  
Cell Culture ◽  
Articular Cartilage ◽  
Cartilage Tissue Engineering ◽  
Cartilage Regeneration ◽  
Cartilage Tissue ◽  
Future Perspectives ◽  
Mechanical Environment ◽  
Biomechanical Stimuli ◽  
Articular Cartilage Regeneration

Tissue engineering (TE) has brought new hope for articular cartilage regeneration, as TE can provide structural and functional substitutes for native tissues. The basic elements of TE involve scaffolds, seeded cells, and biochemical and biomechanical stimuli. However, there are some limitations of TE; what most important is that static cell culture on scaffolds cannot simulate the physiological environment required for the development of natural cartilage. Recently, bioreactors have been used to simulate the physical and mechanical environment during the development of articular cartilage. This review aims to provide an overview of the concepts, categories, and applications of bioreactors for cartilage TE with emphasis on the design of various bioreactor systems.

scholarly journals Small Ruminant Models for Articular Cartilage Regeneration by Scaffold-Based Tissue Engineering

2021 ◽  
Vol 2021 ◽  
pp. 1-14
Author(s):  
Liqing Peng ◽  
Bin Zhang ◽  
Xujiang Luo ◽  
Bo Huang ◽  
Jian Zhou ◽  
...  
Keyword(s):  
Tissue Engineering ◽  
Articular Cartilage ◽  
Animal Models ◽  
Rational Design ◽  
Small Ruminant ◽  
Cartilage Regeneration ◽  
Large Animal ◽  
Tissue Engineering Scaffolds ◽  
Therapeutic Concepts ◽  
Articular Cartilage Regeneration

Animal models play an important role in preclinical studies, especially in tissue engineering scaffolds for cartilage repair, which require large animal models to verify the safety and effectiveness for clinical use. The small ruminant models are most widely used in this field than other large animals because they are cost-effective, easy to raise, not to mention the fact that the aforementioned animal presents similar anatomical features to that of humans. This review discusses the experimental study of tissue engineering scaffolds for knee articular cartilage regeneration in small ruminant models. Firstly, the selection of these scaffold materials and the preparation process in vitro that have been already used in vivo are briefly reviewed. Moreover, the major factors influencing the rational design and the implementation as well as advantages and limitations of small ruminants are also demonstrated. As regards methodology, this paper applies principles and methods followed by most researchers in the process of experimental design and operation of this kind. By summarizing and comparing different therapeutic concepts, this paper offers suggestions aiming to increase the effectiveness of preclinical research using small ruminant models and improve the process of developing corresponding therapies.

scholarly journals Relevant Local Fatwā on The Issues of Using Human Tissues in Articular Cartilage Tissue Engineering Experimentation

2021 ◽  
Vol 20 (1) ◽  
Author(s):  
Muhammad Aa’zamuddin AR ◽  
Nur Syamimi MA ◽  
Abdurezak AH ◽  
Azhim A ◽  
Munirah S
Keyword(s):  
Tissue Engineering ◽  
Articular Cartilage ◽  
Biological Samples ◽  
Cartilage Tissue Engineering ◽  
Cartilage Regeneration ◽  
Joint Disease ◽  
Cartilage Tissue ◽  
Medical Procedure ◽  
Human Donor ◽  
Articular Cartilage Regeneration

In articular cartilage tissue engineering (ACTE) experimentation, the researchers have utilised cells and tissues sampled from the human donor for research purposes. The cells and tissues may be harvested from the living donor’s discarded tissues through a medical procedure, e.g. the total knee replacement surgery. The small pieces of a tissue sample taken from the human donor are essential to study the articular cartilage regeneration for treating joint disease, i.e. osteoarthritis. However, the procedure has raised some ethical and fiqh (Islamic jurisprudence) concerns. The study was done by utilising the secondary analysis of local Muslim jurists’ opinions (fatwā) related to the sampling of human biological samples. This paper explores the scenarios of using cell sources taken from the living human donor through the existing fatwā of local Muslim jurists (fuqahā`). The scenarios include: (1) taking samples from the living donor, and (2) discarding human tissue, as practised in ACTE experimentation. The current fatwā has shown that honouring every part of a human body is considered essential in Islam. ACTE researchers may utilise the biological samples from living donors as alternatives in studying articular cartilage regeneration. The donation of human biological samples for research purposes in ACTE experimentation, obtained from a medical procedure, may be permissible, should the stipulated terms and conditions were observed, and the procedure does not cause any additional harm to the donor.

Materials for Articular Cartilage Regeneration

2012 ◽  
Vol 5 (3) ◽  
pp. 187-199 ◽  
Author(s):  
Aysegul Tombuloglu ◽  
Ayse B. Tekinay ◽  
Mustafa O. Guler
Keyword(s):  
Articular Cartilage ◽  
Cartilage Regeneration ◽  
Articular Cartilage Regeneration
Sign in / Sign up

Export Citation Format

Share Document