scholarly journals A Simple Way to Produce Gold Nanoshells for Cancer Therapy

2019 ◽  
Author(s):  
Rosa Isela Ruvalcaba Ontiveros ◽  
José Alberto Duarte Moller ◽  
Anel Rocío Carrasco Hernandez ◽  
Hilda Esperanza Esparza-Ponce ◽  
Erasmo Orrantia Borunda ◽  
...  
Keyword(s):  
Cancer Therapy ◽  
Gold Nanoshells

Bifunctional nanomaterials for the imaging and treatment of cancer

2017 ◽  
Author(s):  
A. Burke ◽  
D. Carroll ◽  
Frank Torti ◽  
S.V. Torti
Keyword(s):  
Cancer Therapy ◽  
Gold Nanorods ◽  
Anticancer Agents ◽  
Thermal Therapy ◽  
Gold Nanoshells ◽  
Oxide Nanoparticles ◽  
Multiwalled Carbon ◽  
Future Directions ◽  
Multifunctional Agents ◽  
The Subject

This article examines the potential of bifunctional nanomaterials for the imaging and treatment of cancer. Several nanomaterials possess properties desirable for a cancer therapy and have been the subject of research as anticancer agents. Those that have received the most attention include encapsulated iron oxides, single- and multiwalled carbon nanotubes, gold nanorods and gold nanoshells. This article first considers thermal ablative therapy incancer, focusing on the mechanisms of thermotoxicity and thermoresistance before discussing a number of nanomaterials with applications for cancer treatment. In particular, it evaluates the use of nanomaterials in thermal therapy. It also looks at gold nanoshells and nanorods, taking into account their physical properties, and concludes with an assessment of iron-oxide nanoparticles and future directions for nanomaterials as multifunctional agents for cancer therapy.

scholarly journals Gadolinium-Conjugated Gold Nanoshells for Multimodal Diagnostic Imaging and Photothermal Cancer Therapy

Small ◽  
2013 ◽  
Vol 10 (3) ◽  
pp. 556-565 ◽  
Author(s):  
Andrew J. Coughlin ◽  
Jeyarama S. Ananta ◽  
Nanfu Deng ◽  
Irina V. Larina ◽  
Paolo Decuzzi ◽  
...  
Keyword(s):  
Cancer Therapy ◽  
Diagnostic Imaging ◽  
Gold Nanoshells

Nanoshell Assisted Cancer Therapy: Numerical Simulations

2009 ◽  
Author(s):  
Yildiz Bayazitoglu
Keyword(s):  
Cancer Therapy ◽  
Numerical Simulations ◽  
Near Infrared ◽  
Laser Light ◽  
Local Heating ◽  
Thermal Therapy ◽  
Gold Nanoshells ◽  
Comprehensive Treatment ◽  
Embedded Nanoparticles ◽  
Nir Laser

Since the near infrared spectrum (wavelength range of 750–1100 nm) is the region of highest physiological transmisivity, it is the optical communication gateway for the laser energy to propagate into the human body. This optical window also leads to nanoparticle-based approach where embedded nanoparticles absorb the laser light designed to address the specific diagnostic and therapeutic challenges of cancer therapy is exploited extensively in so called plasmonic photo thermal therapy (PPTT). A new tool that is under development for cancer/tumor treatment, in which embedded nanoparticles are manipulated to absorb the Near Infrared (NIR) laser light intensely, aiming at addressing the “nonselectivity” problem that exists in the conventional photo thermal therapy (PPT). The purpose is to seek therapy with a faster and accurate procedure with a comprehensive treatment plan aided with fast and accurate numerical simulations as well. Among all the nanostructures, the noble metal nanoparticles (such as nanoshells) could be tuned to have peak absorption cross section in the NIR spectrum which provide very intense local heating to burn the deeply embedded cancerous tissues and tumors rather than the healthy tissue. Experimental and numerical studies have shown that designed gold nanoshells can be used to remotely and optically induce hyperthermia by embedding certain amount of absorbing dominated gold nanoshells in tumors and then irradiated using NIR laser light. Advancing our capabilities such as modeling, characterization and design of complex nanostructures and their host media for various nanophotonic applications will also increase our effectiveness of induced hyperthermia for its future applications. The computational tools should bridge across the scales from nano to macro, and rapidly compare the predicted behavior of a large number of nanoparticles embedded in tissue so that experimental groups could concentrate laboratory efforts on those resulted configurations most likely to provide optimum results.

Near Infrared Absorbing Nanoparticles for Photothermal Cancer Therapy

2008 ◽  
Author(s):  
Jennifer L. West
Keyword(s):  
Cancer Therapy ◽  
Optical Absorption ◽  
Near Infrared ◽  
Gold Nanoshells ◽  
Control Group ◽  
Gold Colloid ◽  
Optical Resonance ◽  
Normal Tissues ◽  
Nir Light ◽  
And Control

Advances in nanotechnology are expected to lead to the development of new and improved therapeutic strategies, amenable to targeting, that may ultimately revolutionize cancer treatment. For example, we have developed a nanoparticle-based photothermal cancer therapy that has shown high efficacy with virtually no damage to normal tissues (Hirsch et al., 2003, O’Neal et al., 2004, Lowery et al., 2006). This therapeutic strategy employs nanoparticles called nanoshells that are designed to strongly absorb near infrared (NIR) light. Metal nanoshells are a new type of nanoparticle composed of a dielectric (for instance, silica) core coated with an ultrathin metallic (for instance, gold) layer. Gold nanoshells possess physical properties similar to gold colloid, in particular, a strong optical absorption due to the collective electronic response of the metal to light. The optical absorption of gold colloid yields a brilliant red color that has been of considerable utility in consumer-related medical products, such as home pregnancy tests. In contrast, the optical response of gold nanoshells depends dramatically on the relative size of the nanoparticle core and the thickness of the gold shell. By varying the relative core and shell thicknesses, the color of gold nanoshells can be varied across a broad range of the optical spectrum that spans the visible and the near infrared spectral regions (Oldenburg et al., 1999). Gold nanoshells can be made to either preferentially absorb or scatter light at their plasmon resonance by varying the size of the particle relative to the wavelength of the light at their optical resonance. For cancer therapy, nanoshells are injected intravenously and allowed to accumulate in tumor sites due to the leakiness of the vasculature (EPR) and/or molecular targeting. Accumulation in the tumor sites peaks after several hours, at which time the tissue region is illuminated with NIR light for several minutes. NIR light is not absorbed to a significant extent by tissue components, but is strongly absorbed by nanoshells within the tumor. This leads to rapid heating of the tumor tissue without damage to adjacent normal tissues. In preliminary studies, complete tumor regression and 100% survival with no regrowth has been achieved. Mice with CT26 colon carcinoma tumors (4 mm diameter) were injected intravenously with NIR absorbing nanoshells that were coated with PEG-SH. 6 hr following nanoshell injection, the tumor sites were illuminated with light from a 820 nm diode laser (4 W/cm2) for 4 min. Animals in a sham group received a saline injection instead of nanoshells prior to NIR treatment, while a control group was untreated. Tumor size and animal survival were then tracked. As shown in Figure 1, all tumors treated with nanoshells had completely regressed within 10 days of treatment, while sham and control tumors had grown dramatically. Furthermore, all sham and control animals died within 20 days of treatment, while all nanoshell-treated mice continue to live (+12 months) with no tumor regrowth (Figure 2, O’Neal et al., 2004). Excellent nanoshell biocompatibility has been observed.

Fabrication of gold nanoshells for improvement of cell apoptosis and its application in photothermal cancer therapy

2020 ◽  
Vol 10 (8) ◽  
pp. 1204-1212
Author(s):  
Tengbiao Ma ◽  
Xue Guan ◽  
Dan Wu ◽  
Xinxia Wang ◽  
Yali Cui
Keyword(s):  
Cancer Therapy ◽  
Cell Apoptosis ◽  
Near Infrared ◽  
Biomedical Application ◽  
Treatment Method ◽  
Gold Nanoshells ◽  
Tunel Staining ◽  
Novel Strategy

For cancer diagnosis and therapeutics, we adopted a novel strategy and established a new approach by using transarterial administration of gold nanoshells on silica nanorattles (GSNs) for multifunctional biomedical application. The GSNs exhibit high biocompatibility and stability in vitro and in vivo. It was found that an arterial administration of GSNs showed six-fold higher efficiency than the venous method. In this study, we found that the system of using GSNs had a high near-infrared (NIR) absorbance and excellent photothermal transfer capability for cancer photothermal therapy (PTT) efficiently. More importantly, the GSN treatment method, involving interventional procedures and nanomaterials, showed great potential to promote tumor apoptosis in all research. Using CT imaging technology, we monitored the volume change of tumors and confirmed cell apoptosis by TUNEL staining and immunohistochemistry. Furthermore, arterial administration of GSNs combined with NIR irradiation was established, and the related proteins was examined by Western blotting. Caspase-3 and 9 showed an high expression level within tumor tissues. Finally, a comparative study of biodistribution and safety was performed in vivo, and the biocompatibility was carefully evaluated. This GSN-based method was ultimately shown to be a promising approach for cancer therapy.

Rational Design of Branched Nanoporous Gold Nanoshells with Enhanced Physico-Optical Properties for Optical Imaging and Cancer Therapy

ACS Nano ◽  
2017 ◽  
Vol 11 (6) ◽  
pp. 6102-6113 ◽  
Author(s):  
Jibin Song ◽  
Xiangyu Yang ◽  
Zhen Yang ◽  
Lisen Lin ◽  
Yijing Liu ◽  
...  
Keyword(s):  
Optical Properties ◽  
Cancer Therapy ◽  
Optical Imaging ◽  
Rational Design ◽  
Nanoporous Gold ◽  
Gold Nanoshells

Multifunctional metal–organic framework heterostructures for enhanced cancer therapy

2021 ◽  
Author(s):  
Jintong Liu ◽  
Jing Huang ◽  
Lei Zhang ◽  
Jianping Lei
Keyword(s):  
Cancer Therapy ◽  
General Principle ◽  
Biomedical Applications ◽  
Metal Organic Framework ◽  
Metal Organic ◽  
Functional Modulation ◽  
Organic Framework

We review the general principle of the design and functional modulation of nanoscaled MOF heterostructures, and biomedical applications in enhanced therapy.

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