scholarly journals Determination of In Vitro Cytotoxicity and Anti-Angiogenesis for a Bioactive Compound from Aspergillus terreus FC36AY1 Isolated from Aegle marmelos around Western Ghats, India

2019 ◽  
Author(s):  
Vellingiri Manon Mani ◽  
Arockiam Jeyasundar Parimala Gnana Soundari ◽  
Selvam Tamilarasi
Keyword(s):  
Western Ghats ◽  
Aspergillus Terreus ◽  
Bioactive Compound ◽  
In Vitro Cytotoxicity ◽  
Aegle Marmelos

scholarly journals Evaluation of in vitro Cytotoxicity of Essential Oil from Clausena dentata (Willd) Grown in Western Ghats Region, South India

2017 ◽  
Vol 29 (11) ◽  
pp. 2467-2469 ◽  
Author(s):  
Kathirvel Poonkodi ◽  
Ramasamy Anitha ◽  
Sundaramoorthi Vasanthamani ◽  
Jaganathan Karthika ◽  
Velusamy Tamilselvi
Keyword(s):  
Essential Oil ◽  
Western Ghats ◽  
South India ◽  
In Vitro Cytotoxicity

scholarly journals Biocatalytic Synthesis of a Novel Bioactive Ginsenoside Using UDP-Glycosyltransferase from Bacillus subtilis 168

Catalysts ◽  
2020 ◽  
Vol 10 (3) ◽  
pp. 289 ◽  
Author(s):  
Yumei Hu ◽  
Hao Li ◽  
Yingying Qu ◽  
Xiao Zhang ◽  
Juankun Zhang ◽  
...  
Keyword(s):  
Bacillus Subtilis ◽  
Bioactive Compound ◽  
Biological Properties ◽  
In Vitro Cytotoxicity ◽  
Water Soluble ◽  
Hydroxyl Group ◽  
Uridine Diphosphate ◽  
Ginsenoside Rg3 ◽  
Bacillus Subtilis 168

Ginsenoside Rg3 is a bioactive compound from Panax ginseng and exhibits diverse notable biological properties. Glycosylation catalyzed by uridine diphosphate-dependent glycosyltransferase (UGT) is the final biosynthetic step of ginsenoside Rg3 and determines its diverse pharmacological activities. In the present study, promiscuous UGT Bs-YjiC from Bacillus subtilis 168 was expressed in Escherichia coli and purified via one-step nickel chelate affinity chromatography. The in vitro glycosylation reaction demonstrated Bs-Yjic could selectively glycosylate the C12 hydroxyl group of ginsenoside Rg3 to synthesize an unnatural ginsenoside Rd12. Ginsenoside Rd12 was about 40-fold more water-soluble than that of ginsenoside Rg3 (90 μM). Furthermore, in vitro cytotoxicity of ginsenoside Rd12 against diverse cancer cells was much stronger than that of ginsenoside Rg3. Our studies report the UGT-catalyzed synthesis of unnatural ginsenoside Rd12 for the first time. Ginsenoside Rd12 with antiproliferative activity might be further exploited as a potential anticancer drug.

scholarly journals Determination of phenolic profile by HPLC–ESI-MS/MS, antioxidant activity, in vitro cytotoxicity and anti-herpetic activity of propolis from the Brazilian native bee Melipona quadrifasciata

2019 ◽  
Vol 29 (3) ◽  
pp. 339-350 ◽  
Author(s):  
Sabrina Hochheim ◽  
Alessandro Guedes ◽  
Ligia Faccin-Galhardi ◽  
Daniele Zendrini Rechenchoski ◽  
Carlos Nozawa ◽  
...  
Keyword(s):  
Antioxidant Activity ◽  
In Vitro Cytotoxicity ◽  
Phenolic Profile ◽  
Esi Ms ◽  
Melipona Quadrifasciata ◽  
Native Bee
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