scholarly journals Murine Gammaherpesvirus 68 (MHV-68), a Newly Discovered Tick Borne Virus

2019 ◽  
Author(s):  
Marcela Kúdelová ◽  
Iveta Štibrániová
Keyword(s):  
Murine Gammaherpesvirus ◽  
Gammaherpesvirus 68 ◽  
Murine Gammaherpesvirus 68

scholarly journals Alpha beta-crystallin expression and presentation following infection with murine gammaherpesvirus 68

Autoimmunity ◽  
2013 ◽  
Vol 46 (6) ◽  
pp. 399-408 ◽  
Author(s):  
Vinita S. Chauhan ◽  
Daniel A. Nelson ◽  
Ian Marriott ◽  
Kenneth L. Bost
Keyword(s):  
Murine Gammaherpesvirus ◽  
Alpha Beta ◽  
Gammaherpesvirus 68 ◽  
Murine Gammaherpesvirus 68

scholarly journals Two Kinetic Patterns of Epitope-Specific CD8 T-Cell Responses following Murine Gammaherpesvirus 68 Infection

2010 ◽  
Vol 84 (6) ◽  
pp. 2881-2892 ◽  
Author(s):  
Michael L. Freeman ◽  
Kathleen G. Lanzer ◽  
Tres Cookenham ◽  
Bjoern Peters ◽  
John Sidney ◽  
...  
Keyword(s):  
T Cell ◽  
Expression Patterns ◽  
T Cell Responses ◽  
Cd8 T Cell ◽  
T Cell Response ◽  
Immune Control ◽  
Murine Gammaherpesvirus ◽  
Cell Responses ◽  
Gammaherpesvirus 68 ◽  
Murine Gammaherpesvirus 68

ABSTRACT Murine gammaherpesvirus 68 (γHV68) provides an important experimental model for understanding mechanisms of immune control of the latent human gammaherpesviruses. Antiviral CD8 T cells play a key role throughout three separate phases of the infection: clearance of lytic virus, control of the latency amplification stage, and prevention of reactivation of latently infected cells. Previous analyses have shown that T-cell responses to two well-characterized epitopes derived from ORF6 and ORF61 progress with distinct kinetics. ORF6487-specific cells predominate early in infection and then decline rapidly, whereas ORF61524-specific cells continue to expand through early latency, due to sustained epitope expression. However, the paucity of identified epitopes to this virus has limited our understanding of the overall complexities of CD8 T-cell immune control throughout infection. Here we screened 1,383 predicted H-2b-restricted peptides and identified 33 responses, of which 21 have not previously been reported. Kinetic analysis revealed a spectrum of T-cell responses based on the rapidity of their decline after the peak acute response that generally corresponded to the expression patterns of the two previously characterized epitopes. The slowly declining responses that were maintained during latency amplification proliferated more rapidly and underwent maturation of functional avidity over time. Furthermore, the kinetics of decline was accelerated following infection with a latency-null mutant virus. Overall, the data show that γHV68 infection elicits a highly heterogeneous CD8 T-cell response that segregates into two distinctive kinetic patterns controlled by differential epitope expression during the lytic and latency amplification stages of infection.

scholarly journals The Gammaherpesvirus Chemokine Binding Protein Binds to the N Terminus of CXCL8

2003 ◽  
Vol 77 (15) ◽  
pp. 8588-8592 ◽  
Author(s):  
Louise M. C. Webb ◽  
Ian Clark-Lewis ◽  
Antonio Alcami
Keyword(s):  
Receptor Binding ◽  
Chemokine Receptor ◽  
Chemokine Receptors ◽  
Binding Protein ◽  
Sequence Similarity ◽  
Structural Requirements ◽  
Murine Gammaherpesvirus ◽  
N Terminus ◽  
Gammaherpesvirus 68 ◽  
Murine Gammaherpesvirus 68

ABSTRACT Viruses encode proteins that disrupt chemokine responses. The murine gammaherpesvirus 68 gene M3 encodes a chemokine binding protein (vCKBP-3) which has no sequence similarity to chemokine receptors but inhibits chemokine receptor binding and activity. We have used a panel of CXCL8 analogs to identify the structural requirements for CXCL8 to bind to vCKBP-3 in a scintillation proximity assay. Our data suggest that vCKBP-3 acts by mimicking the binding of chemokine receptors to CXCL8.

scholarly journals Identification and functional characterization of the left origin of lytic replication of murine gammaherpesvirus 68

Virology ◽  
2009 ◽  
Vol 387 (2) ◽  
pp. 285-295 ◽  
Author(s):  
Danyang Gong ◽  
Jing Qi ◽  
Vaithilingaraja Arumugaswami ◽  
Ren Sun ◽  
Hongyu Deng
Keyword(s):  
Functional Characterization ◽  
Lytic Replication ◽  
Murine Gammaherpesvirus ◽  
Gammaherpesvirus 68 ◽  
Murine Gammaherpesvirus 68

Altered host response to murine gammaherpesvirus 68 infection in mice lacking the tachykinin 1 gene and the receptor for substance P

Neuropeptides ◽  
2011 ◽  
Vol 45 (1) ◽  
pp. 49-53 ◽  
Author(s):  
John P. Quinn ◽  
Anja Kipar ◽  
David J. Hughes ◽  
Elaine Bennett ◽  
Helen Cox ◽  
...  
Keyword(s):  
Substance P ◽  
Host Response ◽  
Murine Gammaherpesvirus ◽  
Gammaherpesvirus 68 ◽  
Murine Gammaherpesvirus 68

scholarly journals Murine Gammaherpesvirus 68 Evades Host Cytokine Production via Replication Transactivator-Induced RelA Degradation

2011 ◽  
Vol 86 (4) ◽  
pp. 1930-1941 ◽  
Author(s):  
X. Dong ◽  
Z. He ◽  
D. Durakoglugil ◽  
L. Arneson ◽  
Y. Shen ◽  
...  
Keyword(s):  
Cytokine Production ◽  
Murine Gammaherpesvirus ◽  
Gammaherpesvirus 68 ◽  
Murine Gammaherpesvirus 68
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