scholarly journals Experimental Results Help Shape the Development of Personalized Medicine in Colorectal Cancer

2019 ◽  
Author(s):  
Rania B. Georges ◽  
Hassan Adwan ◽  
Martin R. Berger
Keyword(s):  
Colorectal Cancer ◽  
Personalized Medicine ◽  
Experimental Results

scholarly journals Identification of Novel Mutations in Colorectal Cancer Patients Using AmpliSeq Comprehensive Cancer Panel

2021 ◽  
Vol 11 (6) ◽  
pp. 535
Author(s):  
Bader Almuzzaini ◽  
Jahad Alghamdi ◽  
Alhanouf Alomani ◽  
Saleh AlGhamdi ◽  
Abdullah A. Alsharm ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Personalized Medicine ◽  
Cancer Patients ◽  
Biomarker Discovery ◽  
Local Population ◽  
Network Analyses ◽  
Functional Perspective ◽  
Novel Variants ◽  
Colorectal Cancer Patients ◽  
Cancer Panel

Biomarker discovery would be an important tool in advancing and utilizing the concept of precision and personalized medicine in the clinic. Discovery of novel variants in local population provides confident targets for developing biomarkers for personalized medicine. We identified the need to generate high-quality sequencing data from local colorectal cancer patients and understand the pattern of occurrence of variants. In this report, we used archived samples from Saudi Arabia and used the AmpliSeq comprehensive cancer panel to identify novel somatic variants. We report a comprehensive analysis of next-generation sequencing results with a coverage of >300X. We identified 466 novel variants which were previously unreported in COSMIC and ICGC databases. We analyzed the genes associated with these variants in terms of their frequency of occurrence, probable pathogenicity, and clinicopathological features. Among pathogenic somatic variants, 174 were identified for the first time in the large intestine. APC, RET, and EGFR genes were most frequently mutated. A higher number of variants were identified in the left colon. Occurrence of variants in ERBB2 was significantly correlated with those of EGFR and ATR genes. Network analyses of the identified genes provide functional perspective of the identified genes and suggest affected pathways and probable biomarker candidates. This report lays the ground work for biomarker discovery and identification of driver gene mutations in local population.

scholarly journals Study protocol on the role of intestinal microbiota in colorectal cancer treatment: a pathway to personalized medicine 2.0

2017 ◽  
Vol 32 (7) ◽  
pp. 1077-1084 ◽  
Author(s):  
R. Aarnoutse ◽  
J. M. P. G. M. de Vos-Geelen ◽  
J. Penders ◽  
E. G. Boerma ◽  
F. A. R. M. Warmerdam ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Personalized Medicine ◽  
Cancer Treatment ◽  
Intestinal Microbiota ◽  
Study Protocol ◽  
Medicine 2.0 ◽  
Colorectal Cancer Treatment

Valuing personalized medicine: willingness to pay for genetic testing for colorectal cancer risk

2007 ◽  
Vol 4 (3) ◽  
pp. 341-350 ◽  
Author(s):  
Stephanie L Van Bebber ◽  
Su-Ying Liang ◽  
Kathryn A Phillips ◽  
Deborah Marshall ◽  
Judith Walsh ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Genetic Testing ◽  
Personalized Medicine ◽  
Cancer Risk ◽  
Willingness To Pay ◽  
Colorectal Cancer Risk
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