scholarly journals Biological Function of Exosomes as Diagnostic Markers and Therapeutic Delivery Vehicles in Carcinogenesis and Infectious Diseases

Nanomedicines ◽  
2019 ◽  
Author(s):  
Brennetta J. Crenshaw ◽  
Brian Sims ◽  
Qiana L. Matthews
Keyword(s):  
Infectious Diseases ◽  
Biological Function ◽  
Diagnostic Markers ◽  
Therapeutic Delivery ◽  
Delivery Vehicles

scholarly journals Multifunctional Applications of Engineered Extracellular Vesicles in the Treatment of Cancer

Endocrinology ◽  
2021 ◽  
Vol 162 (3) ◽  
Author(s):  
Fernanda G Kugeratski ◽  
Kathleen M McAndrews ◽  
Raghu Kalluri
Keyword(s):  
Cancer Cells ◽  
Extracellular Vesicles ◽  
Anticancer Agents ◽  
Antitumor Immunity ◽  
Therapeutic Delivery ◽  
Signaling Mechanisms ◽  
Delivery Vehicles ◽  
Complex Signaling ◽  
Interfering Rna ◽  
Target Cancer

Abstract Extracellular vesicles (EVs) are key players of intercellular communication in the physiological and pathological setting. In cancer, EVs mediate complex signaling mechanisms between cancer cells and the tumor microenvironment (TME), and can influence tumor progression and the response to existing therapies. Importantly, EVs can be loaded with therapeutic agents and modified to display tumor-targeting molecules. In the field of nanomedicine, EVs have been engineered to serve as therapeutic delivery vehicles for several anticancer agents, including antibodies, chemotherapy, compounds, CRISPR/Cas9 (clustered regularly interspaced short palindromic repeats–associated endonuclease 9), and small interfering RNA (siRNA). Notably, the engineered EVs were shown to suppress malignant features of cancer cells, to elicit antitumor immunity, and to decrease tumor angiogenesis. Here, we review the EV-based therapies designed to target cancer cells and to educate components of the TME to drive antitumor responses. These studies illustrate the multifunctional applications of EVs in the development of anticancer therapies and their translational potential for cancer treatment.

scholarly journals EV Cargo Sorting in Therapeutic Development for Cardiovascular Disease

Cells ◽  
2021 ◽  
Vol 10 (6) ◽  
pp. 1500
Author(s):  
Cherrie D. Sherman ◽  
Shweta Lodha ◽  
Susmita Sahoo
Keyword(s):  
Cardiovascular Disease ◽  
Biological Molecules ◽  
Bioactive Molecules ◽  
Therapeutic Interventions ◽  
Target Cells ◽  
Drug Delivery Vehicles ◽  
Therapeutic Delivery ◽  
Therapeutic Development ◽  
Delivery Vehicles ◽  
Cargo Sorting

Cardiovascular disease remains the leading cause of morbidity and mortality in the world. Thus, therapeutic interventions to circumvent this growing burden are of utmost importance. Extracellular vesicles (EVs) actively secreted by most living cells, play a key role in paracrine and endocrine intercellular communication via exchange of biological molecules. As the content of secreted EVs reflect the physiology and pathology of the cell of their origin, EVs play a significant role in cellular homeostasis, disease pathogenesis and diagnostics. Moreover, EVs are gaining popularity in clinics as therapeutic and drug delivery vehicles, transferring bioactive molecules such as proteins, genes, miRNAs and other therapeutic agents to target cells to treat diseases and deter disease progression. Despite our limited but growing knowledge of EV biology, it is imperative to understand the complex mechanisms of EV cargo sorting in pursuit of designing next generation EV-based therapeutic delivery systems. In this review, we highlight the mechanisms of EV cargo sorting and methods of EV bioengineering and discuss engineered EVs as a potential therapeutic delivery system to treat cardiovascular disease.

scholarly journals Lipidated poly(amino acid) nanostructures as versatile therapeutic delivery vehicles

2020 ◽  
Author(s):  
Josiah D. Smith ◽  
Leah N. Cardwell ◽  
David Porciani ◽  
Andrew J. Greenwald ◽  
Aiden C. Ellis ◽  
...  
Keyword(s):  
Amino Acid ◽  
Self Assembly ◽  
Therapeutic Potential ◽  
Dna Aptamer ◽  
Delivery Device ◽  
Therapeutic Delivery ◽  
Non Hodgkin Lymphoma ◽  
Fine Control ◽  
Delivery Vehicles ◽  
Highly Hydrophobic

AbstractPoly(amino acid)s are a diverse and capable class of polymers with significant potential for utilization in a wide variety of drug delivery applications. A sub-class of these biomaterials known as lipidated poly(amino acid)s (LPAAs) are amphiphiles composed of both hydrophobic and hydrophilic domains yielding interesting physical properties. In this article, we describe our efforts in developing a novel class of lysine and valine containing LPAAs synthesized via hexadecylamine initiated N-carboxyanhydride ring-opening polymerization (NCA-ROP). These highly hydrophobic LPAAs were found capable of undergoing hydrophobically-driven self-assembly into small nanostructures as well as being forced into larger nanostructures using a novel dump-and-stir nanoprecipitation process. This process yielded fine control over resulting nanoparticle size and cargo entrapment. Furthermore, cell-targeting DNA aptamer modification of doxorubicin-loaded LPAA nanoparticles induced significant death of co-incubated Non-Hodgkin Lymphoma cells providing exciting evidence of the therapeutic potential of this novel biomaterials-based delivery device.

scholarly journals Intellectual property issues in nanotechnology

1969 ◽  
Vol 13 (3) ◽  
Author(s):  
Lars Genieser ◽  
Michael Gollin
Keyword(s):  
Intellectual Property ◽  
Medical Applications ◽  
Nanoscale Materials ◽  
Therapeutic Delivery ◽  
Wide Range ◽  
The Us ◽  
Antitrust Laws ◽  
Commercially Important ◽  
Delivery Vehicles ◽  
Targeted Therapeutic

Emerging nanotechnologies have the potential to impact a wide range of commercially important bioscience and medical applications. For example, researchers are developing nanoscale materials as diagnostic probes and targeted therapeutic delivery vehicles. By filing patents, companies can protect their intellectual property and leverage their developments over the marketplace in a way that is consistent with antitrust laws. Policies and doctrines of the US Patent and Trademark Office pertaining to nanotechnology continue to develop. Companies must be aware of challenges and strategies particular to nanotechnology in seeking patents in order to maximise the value of their innovations.

Phages as therapeutic delivery vehicles.

2012 ◽  
pp. 86-100 ◽  
Author(s):  
J. Clark ◽  
S. T. Abedon ◽  
P. Hyman
Keyword(s):  
Therapeutic Delivery ◽  
Delivery Vehicles

scholarly journals Design and Construction of pH-Selective Self-Lytic Liposome System

Processes ◽  
2020 ◽  
Vol 8 (12) ◽  
pp. 1526
Author(s):  
Ayumi Kashiwada ◽  
Kana Namiki ◽  
Haruka Mori
Keyword(s):  
Delivery Systems ◽  
Therapeutic Drug ◽  
Acidic Ph ◽  
Central Question ◽  
Release Behavior ◽  
Therapeutic Delivery ◽  
Selective Membrane ◽  
Delivery Vehicles ◽  
Or Gene ◽  
Ph Range

Liposomes are well-investigated drug or gene delivery vehicles for chemotherapy, used by taking advantage of their biocompatibility and biodegradability. A central question on the construction of intracellular liposomal delivery systems is to entrap the liposomes of interest in the highly acidic and proteolytic endosomal environment. In the other words, it is essential that the liposomes release a therapeutic drug into the cytosol before they are degraded in the endosome. As a strategy to enhance the endosome escape, the self-lytic liposomes with acidic pH-selective membrane active polypeptide are considered highly effective. Here, an acidic pH-selective membrane-lytic polypeptide (LPE) and its retro isomer (rLPE) were designed, and then their membrane-lytic activities against EggPC liposomes were determined. It was noticed that the rLPE polypeptide showed an increase in activity compared with the LPE polypeptide. Furthermore, the rLPE polypeptide was conjugated to liposomes via a flexible Gly-Gly-Gly-Gly linker to facilitate the pH-selective content release. The rLPE anchoring liposomes exhibited distinctly different contents release behavior at physiological and endosomal pHs, namely typical contents release from liposomes was positively observed at acidic pH range. The overarching goal of this paper is to develop efficient pH-selective therapeutic delivery systems by using our findings.

Mesenchymal Stem Cells as Therapeutic Delivery Vehicles Targeting Tumor Stroma

2011 ◽  
Vol 26 (6) ◽  
pp. 767-773 ◽  
Author(s):  
Nedime Serakinci ◽  
Rikke Christensen ◽  
Umut Fahrioglu ◽  
Flemming Brandt Sorensen ◽  
Frederik Dagnæs-Hansen ◽  
...  
Keyword(s):  
Stem Cells ◽  
Mesenchymal Stem Cells ◽  
Tumor Stroma ◽  
Therapeutic Delivery ◽  
Delivery Vehicles

scholarly journals Prevalence of diagnostic markers for infectious diseases in blood donators in the zone of Divinópolis/ MG

2019 ◽  
Vol 29 ◽  
Author(s):  
Priscila Santos Soares ◽  
Isabella Meira Marcondes ◽  
Larissa Oliveira dos Reis ◽  
Lívia Bárbara Cordeiro Alves ◽  
Mayara Araújo Silva ◽  
...  
Keyword(s):  
Infectious Diseases ◽  
Diagnostic Markers
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