scholarly journals Clinical Relevance of Medicinal Plants and Foods of Vegetal Origin on the Activity of Cytochrome P450

2019 ◽  
Author(s):  
Xóchitl S. Ramírez-Gómez ◽  
Sandra N. Jiménez-García ◽  
Vicente Beltrán Campos ◽  
Esmeralda Rodríguez Miranda ◽  
Gabriel Herrera Pérez ◽  
...  
Keyword(s):  
Cytochrome P450 ◽  
Medicinal Plants ◽  
Clinical Relevance

The Role of Cytochrome P450 Enzymes in the Metabolism of Risperidone and Its Clinical Relevance for Drug Interactions

2004 ◽  
Vol 5 (6) ◽  
pp. 573-579 ◽  
Author(s):  
R. Berecz ◽  
P. Dorado ◽  
A. Rubia ◽  
M. Caceres ◽  
I. Degrell ◽  
...  
Keyword(s):  
Cytochrome P450 ◽  
Drug Interactions ◽  
Clinical Relevance ◽  
Cytochrome P450 Enzymes

scholarly journals Review article: the prevalence and clinical relevance of cytochrome P450 polymorphisms

2007 ◽  
Vol 26 ◽  
pp. 211-219 ◽  
Author(s):  
P. A. H. M. WIJNEN ◽  
R. A. M. OP DEN BUIJSCH ◽  
M. DRENT ◽  
P. M. J. C. KUIPERS ◽  
C. NEEF ◽  
...  
Keyword(s):  
Cytochrome P450 ◽  
Clinical Relevance ◽  
Review Article

scholarly journals Variants in COMT, CYP3A5, CYP2B6, and ABCG2 Alter Quetiapine Pharmacokinetics

Pharmaceutics ◽  
2021 ◽  
Vol 13 (10) ◽  
pp. 1573
Author(s):  
Pablo Zubiaur ◽  
Paula Fernández-Campos ◽  
Marcos Navares-Gómez ◽  
Paula Soria-Chacartegui ◽  
Gonzalo Villapalos-García ◽  
...  
Keyword(s):  
Bipolar Disorder ◽  
Adverse Drug Reaction ◽  
Clinical Trials ◽  
Drug Reaction ◽  
Cytochrome P450 ◽  
Genetic Polymorphism ◽  
Negative Feedback ◽  
Clinical Relevance ◽  
Methyl Transferase ◽  
Depressive Episodes

Quetiapine is an atypical antipsychotic widely used for the treatment of schizophrenia and the depressive episodes of bipolar disorder. The aim of this work was to investigate the effect of variants in relevant pharmacogenes in the pharmacokinetics of quetiapine and to exploratorily evaluate adverse drug reaction (ADR) incidence based on genetic polymorphism. Specifically, 49 healthy volunteers enrolled in two bioequivalence clinical trials were included in this study. In addition, 80 variants in 19 relevant pharmacogenes were genotyped, including cytochrome P450 (CYP) genes, catechol-O-methyl transferase (COMT), other enzymes (e.g., UGT1A1 or UGT1A4), and transporters (e.g., SLCO1B1, ABCB1, or ABCG2). The COMT rs13306278 T allele was significantly related to quetiapine-increased exposure. We demonstrated the existence of quetiapine derivatives with a catechol-like structure (7,8-dihydroxi-quetiapine and 7,8-dihydroxi-N-desalkyl-quetiapine), which would be COMT metabolites and would explain quetiapine accumulation through CYP2D6 and CYP3A4 negative feedback. Moreover, CYP3A5 and CYP2B6 phenotypes were related to quetiapine exposure variability, which confirms (for CYP3A5) and suggests (for CYP2B6) that these enzymes play an important role in quetiapine’s metabolism. Finally, the ABCG2 rs2231142 T allele was related to quetiapine accumulation. Further studies are required to confirm the clinical relevance of our findings.

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